Results 81 to 90 of about 130,939 (260)

INNOVATIONS AND RENOVATIONS OF ENHANCED OIL RECOVERY BY ACOUSTIC FIELDS

Известия высших учебных заведений: Нефть и газ, 2018
The article present a survey of the current status of the oil industry raw materials base, trends and results of research of an acoustic technology, using of the borehole technical noise.
N. V. Shatalova
doaj   +1 more source

Chapter Capturing Lifelong Learning Data through International Surveys and Novel Innovative Methods [PDF]

, 2023
Previous literature has highlighted the predominant use of qualitative research methods within the field of adult education. While a wide range of opportunities to exploit and gather large scale quantitative data are available, these avenues remain underexplored. The aims of this chapter are twofold.
Boeren, Ellen, Lido, Catherine
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

INNOVATIVE METHODS OF LEARNING FOREIGN LANGUAGES: ANALYTICAL SURVEY OF THE SITE FOR STUDENTS-LAWYERS

Constitutional State, 2018
The article presents an analysis and reveals the linguodidactic potential of the French web­site www.vie-publique.fr, examines its features for studying a foreign language and the formation of French-speaking professional communicative competence of law students.
openaire   +4 more sources

Evaluating Patient Experience with Integrated Virtual Care (IVC), a Hybrid Primary Care Model in Rural Ontario, Canada: A Cross-Sectional Survey

Journal of Primary Care & Community Health
Introduction: Canada faces a primary care crisis, especially in rural regions. In Ontario, the innovative, Integrated Virtual Care (IVC) program is a hybrid care model that enrolls patients with a family physician working predominantly remotely, while ...
Samantha Buchanan, Shawna Cronin, Antoine St-Amant, Jonathan Fitzsimon   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Competitive Advantage Achievement through Innovation and Knowledge [PDF]

Journal of Competitiveness, 2013
In today’s highly competitive environment the goal of each organisation is to defeat competition and win new customers. Individuals who are holders of knowledge represent a tool for the generation of innovations.
Urbancova Hana
doaj  

Innovative Teaching Methods in South African Urban High Schools: A Survey Research

, 2008
In South Africa, urban high schools face unique challenges in delivering quality education due to socio-economic disparities and resource limitations. A survey research approach was employed, involving a stratified random sample of teachers from nine randomly selected urban high schools.
Dlamini, Njabulo, Nkabinde, Siyabonzi, Khumalo, Siyabonga, Mngqibiso, Siya   +3 more
openaire   +2 more sources