Results 121 to 130 of about 1,403,442 (314)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Innovative technologies of teaching english [PDF]

, 2017
Русанова Л. І. Нетрадиційні технології у викладанні англійської мови / Русанова Любов Іванівна, Сазанова Лариса Сергіївна // Актуальные научные исследования в современном мире: сборник научных трудов ХXІ Междунар. науч. конф. (г.
ORCID: http://orcid.org/0000-0001-6239-2028, ORCID: http://orcid.org/0000-0002-3722-2593, Rusanova, L. I., Sazanova, L. S., Русанова, Л. І., Сазанова, Л. С.   +5 more
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Critique, technology, and innovation

NOvation — Critical Studies of Innovation
Philosopher of technology, Darryl Cressman, is an assistant professor at Maastricht University. Cressman’s work engages with a wide variety of disciplines and approaches, including Science and Technology Studies (STS), media theory, the history and philosophy of science, innovation studies, and critical theory.
Lisann Penttilä, Darryl Cressman
openaire   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Physical unclonable function using photonic spin Hall effect

Scientific Reports
This study presents a novel method leveraging surface wave-assisted photonic spin Hall effect (PSHE) to construct physical unclonable functions (PUFs).
Divyanshu Divyanshu, Amit Kumar Goyal, Yehia Massoud   +2 more
doaj   +1 more source

Towards the construction of an educational model for dual career parenting:the EMPATIA project [PDF]

, 2018
The European Union supports innovative transnational cooperation and practices between Member States on relevant issues in the field of sports, including a balanced combination of higher education and sporting careers of talented and elite athletes (dual
Ana, Rolo, Andrej, Pisl, Anne, Templet, Antonio, Figueiredo, Antonio, Tessitore, Carlos, Goncalves, Caterina, Pesce, Ciaran, MacDonncha, David, Lavallee, Dominique, Delon, Enrico, Bozzano, Eoin, Rheinisch, Fabrice, Burlot, Flavia, Guidotti, Gary, Ryan, Giles, Warrington, Joerg, Foerster, Kinga, Varga, Laura, Capranica, Laurence, Blondel, Masar, Gjaka, Mojca, Doupona Topic, Nadine, Debois, Rute, Costa, Sara, Rozman   +24 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source