Results 111 to 120 of about 1,403,442 (314)

Ethical Mastery of Innovative Technologies [PDF]

In this paper we present an alternative bio-epistemological-based approach to economic ethics issues, which suggests that economists need not only an understanding of the ecosystem in terms of irreversibility, but even more an understanding of the way ...
Broche, Serban, Munteanu, Costea
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Treatment of Unfavorable Intrabony Defects with Autogenous Bone Graft in Combination with Leukocyte- and Platelet-Rich Fibrin or Collagen Membranes: A Non-Inferiority Study

Medicina
Background and Objectives: Unfavorable intrabony defects (IBDs) are associated with the progression of periodontal disease and tooth loss. Growing scientific evidence has demonstrated the effectiveness of platelet concentrations in periodontal treatment.
Giuseppe Balice, Michele Paolantonio, Paolo De Ninis, Imena Rexhepi, Matteo Serroni, Alessio Frisone, Luigi Romano, Bruna Sinjari, Giovanna Murmura, Beatrice Femminella   +9 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

The Influence of Diet and Physical Activity on Periodontal Health: A Narrative Review

Dentistry Journal
Periodontal diseases, including gingivitis and periodontitis, are chronic inflammatory conditions that compromise the supporting structures of the teeth, often leading to tooth loss and contributing to systemic comorbidities.
Giuseppe Balice, Michele Paolantonio, Giovanna Murmura, Matteo Serroni, Stefania Di Gregorio, Beatrice Femminella   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Feedback-controlled and digitally processed coherent population trapping resonance conversion in 87Rb vapour to high-contrast resonant peak

New Journal of Physics, 2017
This work reports on the study of a new approach to achievement of high-contrast resonant signals from coherent population trapping (CPT) resonances in ^87 Rb vapour based on feedback control and real-time digital processing of several measured ...
S Kobtsev, D Radnatarov, S Khripunov, I Popkov, V Andryushkov, T Steshchenko, V Lunin, Yu Zarudnev   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

On the Problem of Shale Gas Mining in Ukraine [PDF]

, 2017
New sources of power resources are one of the most important and central tasks for the human. In these latter days all energy-dependent countries develop alternative technologies to produce renewable fuel: nuclear power, wind power, solar power ...
Sudoplatov, Vladyslav, Tykhonenko, V. V., Yavorsky, A. V.   +2 more
core   +1 more source