Results 91 to 100 of about 409,233 (317)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Multimode approach using Reinforcement Learning and Digital Twin for operating mode management

Production Engineering Archives
Managing operating modes in a multimode production system represents a complex challenge that necessitates both meticulous and reactive planning. The challenge resides in coordinating and optimizing the different modes to address variations in demand ...
Elqabli Zineb, Kamach Oulaid, Chater Youness   +2 more
doaj   +1 more source

Collaboration in Context as a Framework for Designing Innovative Mobile Learning Activities

, 2008
In this chapter we describe our continuing efforts related to the design, implementation and evaluation of innovative educational activities supported by ubiquitous computing in the AMULETS (Advanced Mobile and Ubiquitous Learning Environments for ...
Spikol, Daniel,, Kurti, Arianit,, Milrad, Marcelo,   +2 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

COVID-19: WAYS TO IMPROVE TREATMENT OUTCOMES. TRANSFORMING PERCEPTIONS ABOUT INTENSIVE CARE OF CORONAVIRUS INFECTION

Клінічна та профілактична медицина
Introduction. Given the lack of effective specific antiviral therapy for COVID-19, the main focus is currently on symptomatic and respiratory support. Almost all hospitalized patients are recommended to undergo oxygen therapy, while the WHO recommended ...
Dmytro D. Diachuk, Oleg L. Ziukov, Volodymyr I. Cherniy, Oleksandr V. Naumenko, Anatolii I. Denysenko   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cost-Saving production technologies and strategic delegation [PDF]

This work analyzes a managerial delegation model in which firms that produce a differentiated good can choose between two production technologies: a low marginal cost technology and a high marginal cost technology.
Olaizola Ortega, María Norma, Bárcena Ruiz, Juan Carlos   +1 more
core  

Innovative development of banking technologies

, 2023
⬇️ Доступ до роботи тільки на території бібліотеки ОНЕУ, для переходу натисніть на посилання нижчеУ роботі узагальнюються особливості використання та запровадження інноваційних банківських технологій.
Сарєва, О.Г.
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Treatment of Multiple RT1 Gingival Recessions Using a Coronally Advanced Flap Associated with L-PRF or Subgingival Connective Tissue Graft from Maxillary Tuberosity: A Randomized, Controlled Clinical Trial

Dentistry Journal
The goal of plastic periodontal surgery is to obtain complete root coverage, increasing gingival thickness (GT), a positive prognostic factor for gingival margin stability over time. The aim of this study was to compare the effectiveness of the Coronally
Giuseppe Balice, Michele Paolantonio, Matteo Serroni, Paolo De Ninis, Imena Rexhepi, Alessio Frisone, Stefania Di Gregorio, Luigi Romano, Bruna Sinjari, Giovanna Murmura, Beatrice Femminella   +10 more
doaj   +1 more source