Results 71 to 80 of about 1,403,442 (314)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sil1-deficient fibroblasts generate an aberrant extracellular matrix leading to tendon disorganisation in Marinesco-Sjögren syndrome

Journal of Translational Medicine
Background Marinesco-Sjögren syndrome (MSS) is an autosomal recessive neuromuscular disorder that arises in early childhood and is characterized by congenital cataracts, myopathy associated with muscle weakness, and degeneration of Purkinje neurons ...
Laura Amodei, Anna Giulia Ruggieri, Francesca Potenza, Marianna Viele, Beatrice Dufrusine, Raffaella Franciotti, Laura Pietrangelo, Matteo Ardini, Liborio Stuppia, Luca Federici, Vincenzo De Laurenzi, Michele Sallese   +11 more
doaj   +1 more source

Cyberbullying [PDF]

, 2017
Innovative communication technologies have changed in our lives crucially. An easy platform for communication between people from different parts of the world has appeared, which is known as the Internet.
Gerasina, A.V., Stetsyuk, Dar’ya, Zuyenok, I. І.   +2 more
core  

Developing system models to help Great Britain's railways embrace innovative technologies with confidence [PDF]

, 2013
Railways are under pressure to become more efficient and cut their costs; innovation has a part to play in achieving these goals. The railway is, however, a complex and closely coupled system, making it difficult in the early stages of development, to be
Bouch, Christopher J. (Mr), Roberts, Clive (Prof)   +1 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Innovative learning technologies [PDF]

, 2018
У робочій навчальній програмі подано мету, зміст та завдання вивчення дисципліни "Інноваційні технології навчання"В рабочей учебной программе представлены цели, содержание и задачи изучения дисциплины "Инновационные технологии обучения"The work ...
Мієр, Тетяна Іванівна
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

COVID-19: WAYS TO IMPROVE TREATMENT OUTCOMES. TRANSFORMING PERCEPTIONS ABOUT INTENSIVE CARE OF CORONAVIRUS INFECTION

Клінічна та профілактична медицина
Introduction. Given the lack of effective specific antiviral therapy for COVID-19, the main focus is currently on symptomatic and respiratory support. Almost all hospitalized patients are recommended to undergo oxygen therapy, while the WHO recommended ...
Dmytro D. Diachuk, Oleg L. Ziukov, Volodymyr I. Cherniy, Oleksandr V. Naumenko, Anatolii I. Denysenko   +4 more
doaj   +1 more source