Results 61 to 70 of about 409,233 (317)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Antibiotic Residues in Meat and Animal Feed and Their Association with Antimicrobial Resistance: Evidence from the Kostanay Region, Kazakhstan

Foods
The widespread use of antibacterial agents in livestock production is associated with antibiotic residues in animal products and feed, posing a potential threat to food safety and contributing to antimicrobial resistance.
Pavel Shevchenko, Zhanaidar Bermukhametov, Albina Gabitova, Alma Dossova, Bakhit Baimenov, Aliya Yskak, Gulnaz Yermoldina, Oxana Tomaruk, Raushan Rychshanova   +8 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A systematic review on removal of osseointegrated implants: un update

BMC Oral Health, 2023
Background Today dental implants represent an effective therapy in case of partial or total edentulism, with an excellent success rate. Despite the results obtained, there may be biological or mechanical complications during the therapy, which lead to ...
Giuseppe Tafuri, Manlio Santilli, Eugenio Manciocchi, Imena Rexhepi, Gianmaria D’Addazio, Sergio Caputi, Bruna Sinjari   +6 more
doaj   +1 more source

Data-driven through-life costing to support product lifecycle management solutions in innovative product development

, 2011
Innovative product usually refers to product that comprises of creativity and new ideas. In the development of such a new product, there is often a lack of historical knowledge and data available to be used to perform cost estimation accurately.
John D. Lanham, Marsh, Robert, Wai Ming Cheung, Cheung, Wai Ming, Mileham, Antony, Robert Marsh, Newnes, Linda, Linda B. Newnes, Antony R. Mileham, Lanham, John   +9 more
core   +1 more source

Innovative inorganic technologies [PDF]

, 2022
The following topics are covered in the textbook: current trends in development of inorganic technologies for various industries, in particular science-intensive technologies, traditional and special methods for obtaining special-purpose materials ...
Dontsova, Tetiana, Kutuzova, Anastasiya
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Robust FCM Algorithm with Local and Gray Information for Image Segmentation

Advances in Fuzzy Systems, 2016
The FCM (fuzzy c-mean) algorithm has been extended and modified in many ways in order to solve the image segmentation problem. However, almost all the extensions require the adjustment of at least one parameter that depends on the image itself.
Hanane Barrah, Abdeljabbar Cherkaoui, Driss Sarsri   +2 more
doaj   +1 more source

Innovations in Microfinance technologies

The Journal of Community Informatics, 2008
An experience to implement PDA technology has been done in Mali, in 2003-2005, to modernize banking operations for a microfinance institution (MFI). This project gave the occasion to experiment the mobile technology, but also the possibility for the poor population to have access to financial services, even if they are far from a large city (rural ...
openaire   +2 more sources