Results 81 to 90 of about 409,233 (317)

Integrating BIM and IoT Technologies in Innovative Fire Management Systems

, 2020
In emergency situations, such as building fires, the rescue team must quickly undertake the most appropriate intervention strategy aimed at preventing loss of human life.
Ada Malagnino, Roberto Conte Rosito, Vincenzo Lacasa, Ilaria Sergi, Luigi Patrono, Vincenzo La Casa, Angelo Corallo   +6 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sil1-deficient fibroblasts generate an aberrant extracellular matrix leading to tendon disorganisation in Marinesco-Sjögren syndrome

Journal of Translational Medicine
Background Marinesco-Sjögren syndrome (MSS) is an autosomal recessive neuromuscular disorder that arises in early childhood and is characterized by congenital cataracts, myopathy associated with muscle weakness, and degeneration of Purkinje neurons ...
Laura Amodei, Anna Giulia Ruggieri, Francesca Potenza, Marianna Viele, Beatrice Dufrusine, Raffaella Franciotti, Laura Pietrangelo, Matteo Ardini, Liborio Stuppia, Luca Federici, Vincenzo De Laurenzi, Michele Sallese   +11 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Selective Adsorption of Ammonia from Nitrogen and Hydrogen Using Zeolite 13X: Isotherm and Breakthrough Studies

Applied Sciences
The separation of synthesised ammonia from unreacted nitrogen and hydrogen is a crucial step in producing high-purity ammonia and enabling the efficient recycling of unreacted gases in the ammonia synthesis process.
Babak Mokhtarani, Ali Salehabadi, Hamid Reza Rahimpour, Jafar Zanganeh, Behdad Moghtaderi   +4 more
doaj   +1 more source

Modular Teaching Technologies as Innovative Components of Modern Pedagogical Technologies

, 2021
The article presents the modern content of one of the most important tasks of the formation of a multi-level system of training, retraining and advanced training of specialists.
Toxirjonovich, O’rinov Nodirbek, Nurdinovna, Yusupova Nodira, G’ulamovna, Temirova Gulbahor   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Innovative Instructional Technologies.

J. Univers. Comput. Sci., 2013
Innovative Instructional ...
openaire   +3 more sources

Innovative agricultural technologies and practices promote productivity and resilience

, 2022
Agricultural productivity is not just essential for sustainably meeting the demands of a growing world. The technologies and practices that enable producers to produce more output with the same amount, or less inputs, can also be harnessed to cultivate ...
Steensland, Ann
core