Results 101 to 110 of about 1,403,442 (314)

SUSTAINABLE DEVELOPMENT OF TERRITORIES OF MINING REGIONS [PDF]

, 2018
Developing innovative technologies of mining coal seams and increasing the competitiveness of coal produced and providing further diversification of the mine using the "post-mining" concept as the basis for sustainable ...
DUBOVIK, Oleksandr, LOHUNOVA, Oleksandra
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Therapeutic Delivery Technology and its Economic Impact [PDF]

, 2019
Therapeutic delivery technology is a current area of high interest in both university and industrial settings. These technologies are being developed in order to deliver therapeutic agents, such as genes, proteins, and drugs, to patients more efficiently.
Savas, Paul E., Jr.
core   +1 more source

Editorial - Evolving Trends in Supply Chain Management: Complexity, New Technologies, and Innovative Methodological Approaches [PDF]

, 2018
Ministerio de Ciencia e Innovación ...
Cannella, Salvatore, Dominguez, Roberto, Framinan, Jose M., Ponte, Borja   +3 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Stormwater Management BMP Report and Website: Innovative Stormwater Treatment Technologies BMP Manual [PDF]

, 2003
The New Hampshire Department of Environmental Services (DES) received money in 2001 from the New Hampshire Estuaries Project (NHEP) to create a manual and a website of Innovative Stormwater Treatment Technology Best Management Practices.
Couture, Steve
core   +2 more sources

Silicon Pixel R&D for the CLIC Tracking Detector

, 2020
The physics aims at the proposed high-energy $e^+e^-$ collider CLIC pose challenging demands on the performance of the detector system. Precise hit-time tagging, an excellent spatial resolutions, and a low mass are required for the vertex and tracking ...
Kröger, Jens
core   +1 more source

Innovative competitiveness of russian regions [PDF]

, 2015
The article analyses the competitive challenges of Russian regional economies and proposes ways of selecting competitive priorities. The author assumes that selection of priorities for improving a region’s innovative competitiveness should involve not ...
Golova, I.M.
core   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Innovative Strategies And Innovative Technologies.

, 2018
In the course of the research: the definition of "innovation potential" is given; normative and legal acts regulating innovative activity are summarized; the tendency to decrease in activity of innovative activity in Ukraine is revealed; foreign experience and the role of innovative strategies in increasing the competitiveness of products, enterprises,
Svitlana Filyppova, Valentyna Saadzhan
openaire   +4 more sources