Results 101 to 110 of about 409,233 (317)

Technological Innovation, Entrepreneurship, and Development [PDF]

, 2011
Industrialization has long been seen as the answer to underdevelopment and poverty. First this led countries to follow protectionist import substitution policies but as these failed developing countries have opened up to trade and FDI and tried to follow strategies of export driven industrialization.
Audretsch, David B., Sanders, Mark
openaire   +5 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

FORECASTING METHOD FOR DISRUPTIVE SPACE TECHNOLOGIES

, 2010
This paper documents a research initiative performed on Disruptive Space Technologies (DST) in the European space sector and elaborates on a method of forecasting them. The research was performed at the DLR in Bremen in co-operation with the University
van der Veen, Egbert Jan
core  

Innovative technologies in mathematics teaching

, 2020
Article analyzes the fact that the answer to the question “how to teach effectively and efficiently?” Requires the development of innovative pedagogical technologies, as well as innovative technologies in teaching mathematics: technology based on problem
J.Kadirov, Eshim Murotovich Mardonov, Kurbon Ostanov   +2 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Innovative Strategies And Innovative Technologies.

, 2018
In the course of the research: the definition of "innovation potential" is given; normative and legal acts regulating innovative activity are summarized; the tendency to decrease in activity of innovative activity in Ukraine is revealed; foreign experience and the role of innovative strategies in increasing the competitiveness of products, enterprises,
Svitlana Filyppova, Valentyna Saadzhan
openaire   +4 more sources

SMALL AND MEDIUM ENTERPRISE’S GROWTH AND NEW TECHNOLOGIES IMPLEMENTATION [PDF]

If managers of many SME do not clearly assume the necessity to modernize their organizations, they will not be able to take advantage of all its resources' potentialities, not only the technological resources, but also of the capacities and ...
Marius-Dan Dalotă
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

INNOVATIVE PRINCIPLES FOR MONITORING RISK FACTORS OF NON-COMMUNICABLE DISEASES AND SUBSTANTIATION OF MECHANISMS OF ITS INTEGRATION INTO INTERSECTORAL HEALTH CARE

Клінічна та профілактична медицина
Introduction. The current stage of healthcare reform requires the active introduction of prevention, in particular of non-communicable diseases, which is due to the prolonged adverse health status of the population, the consequences of the COVID-19 ...
Mykhailo D. Diachuk, Dmytro D. Diachuk, Oleg L. Ziukov, Olena O. Oshyvalova, Viktoriia V. Horachuk   +4 more
doaj   +1 more source