Results 91 to 100 of about 169,462 (286)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
HeliyonThe aim of this study was to evaluate the performance of CHIRPS and TAMSAT satellite rainfall data over the Upper Gelana watershed, where gauged meteorological data to understand the nature of the climate are scarce.
Sileshi Tadesse +2 more
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 7, Page 1244-1258, July 2026.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Patent Trends Analysis as a Basis for Innovation Strategies
Foresight and STI GovernanceThe analysis of patent trends reveals significant patterns that have the potential to drive technological advancements in specific domains, particularly by identifying emerging areas and research gaps. This study examines how the economic appropriation of research and development outcomes mirrors the dynamics of the innovation process and informs ...
Nestor Brandão Neto +2 more
openaire +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
This study aims to investigate variability in precipitation and air temperature data of all provinces in Turkey. The Innovative Trend Pivot Analysis Method (ITPAM) was used to analyze the trend in precipitation (mm) and air temperature (oC) data of ...
Ahmet Iyad Ceyhunlu, Gokmen Ceribasi
core +2 more sources
Innovative trend analysis methods using multi-duration and variable length sub–series
Environmental Research CommunicationsClimate change is among the most critical challenges of our time and is clearly reflected in the rise of global mean temperatures. This study investigates global mean temperature trends for 1854–2023 using innovative trend analysis (ITA), frequency-based
Ismail Dabanli
doaj +1 more source
Standardized Innovative Polygon Trend Analysis for Climate Change Assessment (S-IPTA)
Research and applications on trend analysis have recently been on the agenda and are top priorities in many disciplines due to the effects of climate change.
Alashan, Sadık +2 more
core +1 more source