Results 81 to 90 of about 169,462 (286)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, Volume 16, Issue 7, Page 1314-1327, July 2026.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

INNOVATIVE TREND ANALYSIS METHODOLOGY IN LOGARITHMIC AXIS

Konya Journal of Engineering Sciences, 2020
Future uncertainties of climate change cause people to worry, and therefore, in order toreduce the associated risks, scientific research methodologies are improved continuously. For instance,temperature raises as a result of carbon content increase cause variations in hydro-meteorological dataincluding evaporation, drought, precipitation, runoff, and ...
openaire   +3 more sources

Trend Determinations of Daily Maximum Precipitation Data with Classical and Innovative Methods

Doğal Afetler ve Çevre Dergisi
Climate change has significant effects on the hydrological cycle and determining precipitation trends is of great importance for sustainable management of water resources.
Cihat Sarı, Erdem Çoban, Yavuz Selim Güçlü   +2 more
doaj   +1 more source

An Examination of the Variability of Precipitation Data in Sinop Province With Graphical Innovative Trend Methods

, 2023
With the impact of climate change, irregularities in precipitation regimes are experienced and these irregularities make their effects felt more and more both as droughts and floods.
Köyceğiz, Cihangir, Büyükyıldız, Meral   +1 more
core  

Zoning of groundwater level using innovative trend analysis: Case study at Rechna Doab, Pakistan

, 2023
Groundwater plays a pivotal role in the economy from several country due to the scarcity of surface freshwater. In Pakistan it is the second largest water source which is used for irrigation, drinking and domestic uses.
Arshad, Muhammad, Shahid, Muhammad Adnan, Abbas, Muhammad   +2 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Rainfall and Temperature Trends in Kaduna North and Their Implications for Water Resources

UMYU Scientifica Journal
Rainfall and temperature variability can impact the availability of water resources for agricultural and domestic use.  This study examined the trends in rainfall and temperature, as well as their implications for water resource management.
Nafisat Bello, Haruna Garba, Abbas Abdullahi Ako   +2 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, Volume 16, Issue 7, Page 1387-1399, July 2026.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, Volume 16, Issue 7, Page 1259-1270, July 2026.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, Volume 16, Issue 7, Page 1358-1369, July 2026.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source