Results 71 to 80 of about 169,462 (286)

A Study of Precipitation Changes from 1990 to 2020 in the Leh District of Ladakh Using Innovative Trend Analysis [PDF]

Nature Environment and Pollution Technology
Precipitation plays a crucial role in the hydrological cycle and water resource management in climate-sensitive regions. Identifying the long-term changes in precipitation is essential for understanding the regional climate dynamics. The innovative trend
Padma Namgyal, Shyamal Sarkar and Ramesh Kumar
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An Enhanced Innovative Triangular Trend Analysis of Rainfall Based on a Spectral Approach

, 2021
The world is currently witnessing high rainfall variability at the spatiotemporal level. In this paper, data from three representative rain gauges in northern Algeria, from 1920 to 2011, at an annual scale, were used to assess a relatively new hybrid ...
Al-Ansari, Nadhir,, Zerouali, Bilel,, Elbeltagi, Ahmed,, Santos, Celso Augusto Guimarães, Celso Augusto Guimarães Santos, Zerouali, Bilal,, Al-Ansari, Nadhir, Mesbah Mohamed, Chettih, Mohamed,, Bilal Zerouali, Mohamed, Mesbah,, Nadhir Al-Ansari, Zerouali, Bilel, Zaki Abda, Chettih, Mohamed, Elbeltagi, Ahmed, Santos, Celso Augusto Guimarães,, Bilel Zerouali, Abda, Zaki, Zerouali, Bilal, Mohamed, Mesbah, Mohamed Chettih, Ahmed Elbeltagi, Abda, Zaki,   +23 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Examination of Long-Term Temperature Change in Türkiye: Comparative Evaluation of an Advanced Quartile-Based Approach and Traditional Trend Detection Methods

Atmosphere
The fact that 2023 and subsequently 2024 were the hottest years in history makes it even more important to monitor temperature changes over time. In this study, trends in the mean, maximum, and minimum temperature data of 81 provinces in Türkiye were ...
Omer Levend Asikoglu, Harun Alp, Ibrahim Temel, Pegah Kamali   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis of long-term rainfall trend and extreme in upper northern Thailand

Scientific Reports
Understanding long-term precipitation trends is critical for climate adaptation and water resource management, particularly in regions prone to extreme weather events.
Wipawinee Chaiwino, Kuntalee Chaisee, Chalump Oonariya, Ben Wongsaijai   +3 more
doaj   +1 more source

Innovative Polygon Trend Analysis (IPTA): A Case Study for Precipitation in Thessaloniki during the Last 50 Years (1971–2020)

, 2023
In the present study, the introduction of the Innovative Polygon Trend Analysis (IPTA), a non-parametric trend analysis methodology, is proposed as an alternative to the classical trend analysis methodology, according to which processes (normality ...
Petroula Karacosta, Nikoletta Pakalidou, Theodore Karacostas, Maria Douka   +3 more
core   +1 more source

Innovative trend analysis of air temperature and precipitation in theJinsha River Basin, China [PDF]

, 2020
Trend detection based on hydroclimatological time series is crucial for understanding climate change. In this study, the innovative trend analysis (ITA) method was applied to investigate trends in air temperature and precipitation over the Jinsha River ...
Fu, G., Ranjan Sarukkalige, Wang, Q., Qin Wang, Dong, Z., Guobin Fu, Meng, Q., Sarukkalige, Ranjan, Jia, W., Wenhao Jia, Qing Meng, Zengchuan Dong   +11 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, Volume 16, Issue 7, Page 1271-1292, July 2026.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source