Results 61 to 70 of about 1,509,779 (344)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Impact of consumer innovativeness on shopping styles: a case study of university students from Pakistan

Apstract: Applied Studies in Agribusiness and Commerce, 2019
This study examines the effects of various types of consumers’ innovativeness on the consumer shopping styles. The results highlight that social, hedonic and cognitive innovativeness have an impact on consumer shopping styles, but functional ...
Muhammad Fahid Muqaddas, Zoltán Szakály   +1 more
doaj   +1 more source

ALPPS: Innovation for innovation's sake [PDF]

Surgery, 2016
HEPATIC RESECTION AND ABLATIVE PROCEDURES, which remain the mainstay treatment for patients with resectable colorectal liver metastases (CRLMs), can be facilitated by preoperative volumetric modulation when an insufficient liver remnant and/or diseased parenchyma are anticipated.
Jacques, Belghiti, Safi, Dokmak, Erik, Schadde   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Modeling innovation: determinants of innovativeness and the impact of innovation on firm performance [PDF]

, 2008
The objective of this paper is to report on the method, analysis, and conclusions concerning two research questions formulated as: What are the determinants of innovation at firm level?” and “what is the impact of innovation on firm performance?” The ...
Alpkan, Lutfihak, Alpkan, Lütfihak, Gunday, Gurhan, Günday, Gürhan, Kilic, Kemal, Kılıç, Kemal, Ulusoy , Gunduz, Ulusoy , Gündüz   +7 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Employee well-being and innovativeness: A multi-level conceptual framework based on citation network analysis and data mining techniques.

PLoS ONE, 2023
This study proposes a multilevel conceptual framework for a deeper understanding of the relationship between employee well-being and innovativeness. We overview 49 years of well-being research [1972-2021] and 54 years of research on innovativeness [1967 ...
Yousif Elsamani, Cristian Mejia, Yuya Kajikawa   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source