Results 51 to 60 of about 35,652 (254)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
PREDICTING TEACHER CANDIDATES' PROFESSIONAL INNOVATIVENESS TENDENCIES: THE ROLE OF GENDER, ACHIEVEMENT GOALS, AND ENTREPRENEURSHIP [PDF]
Istraživanja u PedagogijiThis study aims to test whether gender, achievement goals, and entrepreneurship are significant predictors of teacher candidates' tendencies toward professional innovativeness. The research was conducted using a correlational survey model. A total of 351
Ferat Yılmaz +2 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
State policy innovativeness scores V1.1
, 2014 These data include measures of state policy innovativeness drawn from a database of over 180 different policies as used in Boehmke and Skinner (2012) to construct static and dynamic measures covering the period 1912-2009.
Skinner, Paul, Boehmke, Frederick J.
core +1 more source
Spor Bilimleri Araştırmaları DergisiThis study examined the effect of individual innovativeness on entrepreneurship tendencies among sports sciences students and tested whether innovativeness predicts entrepreneurship tendencies.
Zafer Gayretli
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Organisational innovativeness : the role of strategic orientation and environmental scanning [PDF]
, 2012 This study examined the effects of strategic orientation and environmental scanning on a firm’s propensity to innovate (organisational innovativeness).
Murray, Jennifer
core
Organisational and group antecedents of work group service innovativeness
, 2009 This study examined the individual and combined effects of the organisational-level variables of climate and task design, and the group-level variables of group citizenship behaviour (GCB), market orientation, group self-efficacy (GSE), and group climate
Nsenduluka, Evaristo, Shee, Himanshu
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source