Results 181 to 190 of about 1,033,686 (388)
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo+11 more
wiley +1 more source
RESULTS OF PROPHYLACTIC INOCULATION AGAINST PNEUMOCOCCUS IN 12,519 MEN [PDF]
Russell L. Cecil, Julianne Austin
openalex +1 more source
Inoculants are silage additives containing lactic acid bacteria (e.g. Lactobacillus plantarum, other lactobacilli, pediococci or Enterococcus faecium) that help to improve fermentation (production of lactic acid) in the silo. Inoculants bacteria are usually selected from epiphytic microflora or other environments.
openaire +2 more sources
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq+4 more
wiley +1 more source
It is important to provide individual sanitation systems for sewage peri-urban communities or rural areas to minimize impacts on the environment and human health caused by sewage discharge in natura into water resources.
Camila Fernandes Nunes+2 more
doaj
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun+13 more
wiley +1 more source
Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim+11 more
wiley +1 more source
IV. On the effect upon virulence of passage of B. pestis through rats by subcutaneous inoculation without intermediate culture [PDF]
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Development of optimal fermentation expression systems for recombinant proteins: a thesis submitted in partial fulfilment of the requirements for the degree of Masters in Technology at Massey University [PDF]
This research set out to maximise the titre of four recombinant protein products (i.e. Eg95 vaccine antigen against Echinococcus granulosus a aspartyl protease inhibitor homologue, Aspin; a secreted cytokine granulocyte colony stimulating factor (G-CSF);
Manderson, Daniel
core
Surface modification using mussel‐derived polydopamine (PDA) is a versatile and robust biocompatible strategy that enables direct application to various epidermal surfaces, regardless of their morphological complexity or surface characteristics. The PDA‐coated epidermis exhibits multiple anti‐biofouling functionalities, including antibacterial and anti‐
Su Eon Lee+14 more
wiley +1 more source