Results 261 to 270 of about 1,019,691 (337)

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

Advanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu, Qianmin Ou, Qianhui Ren, Zhengshi Li, Hongcheng Chen, Fangcao Lei, Xueli Mao, Songtao Shi, Zetao Chen, Wei Teng   +9 more
wiley   +1 more source

Protection against prolonged pneumococcal infection involves structural changes in C-reactive protein and subsequent binding to both phosphocholine and amyloids on the bacterial surface. [PDF]

Front Immunol
Agrawal A, Ngwa DN, Simons JP, Singh SK.
europepmc   +1 more source

WSGC@FA@PEG/PEI‐SPIONs Mitigate Chemoresistance in Gastric Adenocarcinoma by Modulating the Notch Signaling Pathway and Mitophagy

Advanced Science, EarlyView.
WSGC peptide reverses drug resistance in GA by modulating the Notch signaling pathway and mitophagy at the molecular level. Abstract This study investigates the molecular mechanisms by which superparamagnetic iron oxide nanoparticles (SPIONs) loaded with the WSGC peptide (WSGC@FA@PEG/PEI‐SPIONs)—a 40‐amino acid polypeptide derived from apoC‐III ...
Dongjian Song, Qiuliang Liu, Zechen Yan, Qi Wang, Meng Su, Hui Zhang, Longyan Shi, Yingzhong Fan, Qian Zhang, Heying Yang, Da Zhang   +10 more
wiley   +1 more source

COMMERCIAL MICROBIAL INOCULANTS AND INOCULATED TRANSPLANTS FOR RECLAMATION [PDF]

Journal American Society of Mining and Reclamation, 1985
openaire   +1 more source

Growth Promotion of Maize Exposed to Arsenic and Mercury with a Consortia of Rhizosphere Bacteria Isolated from Mining Tailings. [PDF]

Curr Microbiol
Rojas-Solis D, Rodríguez YMG, Larsen J, Santoyo G, Lindig-Cisneros R.   +4 more
europepmc   +1 more source

III. Observations respecting the Small-Pox and Inoculation in Eastern Countries; with some Account of the Introduction of Vaccination into India [PDF]

Whitelaw Ainslie
openalex   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

Application of Nanocomposites-Based Polymers on Managing Fungal Diseases in Crop Production. [PDF]

Plant Pathol J
Hoang NH, Thanh TL, Saengchan C, Sangpueak R, Thepbandit W, Zhou X, Kamkaew A, Buensanteai K.   +7 more
europepmc   +1 more source