Results 311 to 320 of about 1,051,436 (384)

Lifespan‐Regulated CAR‐Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
Using a tamoxifen‐inducible Hoxb8 system, proliferative bone marrow progenitors can be generated, which are subsequently engineered with an anti‐CEA CAR construct containing a suicide gene (iCas9) and differentiated into CAR‐macrophages. This method facilitates scale up the production of CAR‐macrophages.
Chuancheng Gao, Fangling Hong, Yao Dong, Yong Fu, Yunong Ma, Xuedi Sun, Junfeng Zhang, Jiangning Chen, Zhen Huang   +8 more
wiley   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

The spontaneous neoantigen-specific CD4⁺ T-cell response to a growing tumor is functionally and phenotypically diverse. [PDF]

J Immunother Cancer
Griswold RQ, Brightman SE, Soria Zavala K, Ordaz-Arias MA, Djassemi N, Thota RR, Naradikian MS, Dose H, Alarcon S, Vijayanand P, Peters B, Miller AM, Cohen EEW, Schoenberger SP.   +13 more
europepmc   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Symbiotic Fungus <i>Serendipita indica</i> as a Natural Bioenhancer Against Cadmium Toxicity in Chinese Cabbage. [PDF]

Plants (Basel)
Rahbari A, Esmaielpour B, Azarmi R, Fatemi H, Lajayer HM, Panahirad S, Gohari G, Vita F.   +7 more
europepmc   +1 more source

Art. III.—Inoculating the Human System with Straw Fungi, to protect it against the Contagion of Measles; with some Additional Observations relating to the Influence of Fungoid Growth in producing Disease and in the Fermentation and Putrefaction of Organic Bodies. [PDF]

J H Salisbury
openalex   +1 more source

Utilisation of wastewater for fuel and fodder production and environmental and social benefits in semi-arid, peri-urban zones of sub-Saharan Africa. Third Annual Report: 1/12/2004 - 30/11/2005 [PDF]

, 2006
Alzouma, Z.M., Atta, S., Bathily, H., Bayala, J., Cisse, D., Cisse, Y., Dianda, M., Guindo, S., Ibrahim, M.D., Ibro, G., Ingleby, K., Kante, F., Kone, B., Krasova-Wade, T., Lahbib, M., Laouali, M.S., Maiga, M.S., Munro, R.C., Neyra, M., Saadou, M., Samake, B., Sanon, K., Sidibe, D., Traore, K., Wilson, J., Yattara, I.I.   +25 more
core  

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Mechanisms underlying the biocontrol activity of Serratia marcescens YNAU-SM-1 against Phytophthora infestans in potato. [PDF]

BMC Plant Biol
Liu C, Deng L, Dao J, Wang W, Huang X, Zhang Y, Yang Y, Lu S, Zhao J, Liu X.   +9 more
europepmc   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source