Results 171 to 180 of about 101,237 (263)

M2 Macrophage‐Mimetic and ROS‐Sensitive Hybrid Nanoplatform for Targeted Alleviation of Rheumatoid Arthritis

Exploration, EarlyView.
Rheumatoid arthritis (RA) is the most prevalent inflammatory arthropathy globally and remains incurable nowadays. Herein, an M2 macrophage‐mimetic hybrid nanoplatform (Cel@M2‐L‐MSN) is constructed for concerted RA therapy through joint‐specific accumulation, on‐demand drug release, inflammation resolution, ROS clearance, along with macrophage ...
Yi Xiao, Shiyu Meng, Zhuang Tang, Yonghang Liu, Xican Zhang, Kefan Wu, Yuanhao Liu, Ao Li, Jingyao Feng, Kaixiang Zhou, Hui Guo, Xiaolin Wang   +11 more
wiley   +1 more source

The Regulatory Effect of Histone Deacetylase (HDAC) 1 and 2 on iNOS, IL-6, TNF-α and IL-10 Expression in Canine Macrophages Infected With Leishmania infantum. [PDF]

Parasite Immunol
Venturin GL, Ito LTS, Umino GM, Rebech GT, Lopes FL, de Lima VMF.   +5 more
europepmc   +1 more source

Sustained‐Release Ulcer‐Protective Microarray Patch With Dihydrocapsaicin for Diabetic Wound Regeneration

Exploration, EarlyView.
Schematic illustration of the effect of microneedles incorporating cerium‐based MOF loading dihydrocapsaicin (MN‐MOF@DHC) to scavenge reactive oxygen species (ROS) generation, beanti‐inflammatory, inhibit the apoptosis of endothelial cells (ECs), promote angiogenesis, and accelerate diabetic wound healing. ABSTRACT Diabetic foot ulcers (DFUs) present a
Yuxu Wu, Kan Jiang, Xiao Wen, Chihao Jin, Kai Zhang, Jiakai Zhang, Jiale Jin, Jiaqian Wang, Huiyu Hu, Zonghan Xu, Xianzhu Zhang, Yihe Hu   +11 more
wiley   +1 more source

Nitric oxide-dependent stabilization of vimentin confers chemoresistance in ovarian cancer. [PDF]

Mol Ther Nucleic Acids
Melone G, Bayraktar R, Zhao H, Hynes SO, Kaar F, Freegrove A, Deng J, Baseviciene A, Uzair I, Martinez KO, Guzman-Rojas L, Chervo MF, Li M, Qian W, Zhou J, Phillips A, Zambo KDA, Nikolos F, Chan KS, Thomas C, Francis L, Chang JC.   +21 more
europepmc   +1 more source

Quadruplex Bioactive FAND for Treating Acute Liver Failure Induced by Acetaminophen or Hepatectomy

Exploration, EarlyView.
This work developed a bioactive quadruplex FANDHP@FuEVs with intrinsic inflammation‐targeting properties of M2‐EVs and MSC‐EVs, harnessing the synergistic biological activities by leveraging four natural active components—M2‐EVs, MSC‐EVs, HGF, and PPC—to deliver pleiotropic therapies, including antioxidant, anti‐inflammatory, pro‐regenerative, and M1 ...
Meng Sun, Fang Fang, Juan Liu, Yueyun Fan, Sa Wang, Chuang Zhang, Weiyu Li, Zhengyang Quan, Dongxu Zhao, Min Hu, Jinfeng Zhang   +10 more
wiley   +1 more source

Correction: Microneedle-mediated delivery of Coptis chinensis-derived nanovesicles orchestrating antibacterial and macrophage reprogramming for comprehensive wound healing. [PDF]

J Nanobiotechnology
Xu KM, Lin JQ, Zhuo XX, Xiao L, Zhao YJ, Zhang C, Li SY, Zhang YL, Yang F, Zhao Q, Li CQ, Zhang GJ.   +11 more
europepmc   +1 more source

The Status of INO

Journal of Physics: Conference Series, 2017
openaire   +1 more source

Engineered Nature‐Based Sonosensitizer for Broad‐Spectrum Infectious Tissue Repair via Sono‐Ionic Therapy

Exploration, EarlyView.
A schematic illustration of an engineered nature‐based sonosensitizer enables early‐stage high‐power ultrasound to generate substantial reactive oxygen species for antibacterial effects and late‐stage low‐power sono‐ionic therapy for infected bone repair, infected wound biofilm therapy, and wound regeneration.
Liang Ma, Hongchuan Wang, Weidong Liang, Tao Xu, Jie Lei, Li Zhang, Shutao Gao, Xiaoyu Cai, Qian Li, Wenzhao Wang, Chuanhui Xun, Weibin Sheng, Cao Yang, Yingsong Wang   +13 more
wiley   +1 more source

Binding Affinity and Interaction Profiles of Erinacines and Erinacerins with iNOS and NF-<i>κ</i>B Revealed by Molecular Dynamics Simulations. [PDF]

Int J Mol Sci
Hernandez-Munguia AM, Reyes-Chaparro A, Fregoso-Aguilar TA, Tenorio-Barajas AY, Mendoza-Pérez JA, Aguilar-Garay R, Nicolás-Álvarez DE.   +6 more
europepmc   +1 more source

Potential of Bee Pollen as a Nutraceutical And/Or Functional Ingredient for Metabolic Syndrome Management: In Vitro Antioxidant, Anti‐Inflammatory, and Digestive Enzyme Inhibitory Activities

Food Chemistry International, EarlyView.
Bee pollen samples from China and Spain exhibited in vitro antioxidant, anti‐inflammatory, and digestive enzyme inhibitory activities due to their composition, suggesting their potential as a nutraceutical or functional ingredient to help counteract oxidative stress, chronic inflammation, and metabolic disorders.
Adriana Maite Fernández‐Fernández, Victoria Olt, Jessica Báez, Marcelo Miraballes, Melissa Romero, Cecilia Dauber, Ignacio Vieitez, Estela Santos, Adriana Gámbaro, Alejandra Medrano   +9 more
wiley   +1 more source