Results 181 to 190 of about 200,631 (340)
Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims
In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh +12 morewiley +1 more sourceAdipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen‐Deficient Environments via the Amplifier Extracellular Vesicles
Advanced Science, EarlyView.Chronic systemic inflammation, worsened by estrogen deficiency, underlies and exacerbates periodontitis. Proinflammatory macrophages within visceral adipose tissue are hyperactivated due to hyper‐DNA methylation, releasing small extracellular vesicles (sEVs) similar to those of their parent cells.Danfeng Li, Tian Yang, Yuqian Li, Xinwei Lyu, Cheng Hu, Jiayin Yan, Jiali Tan +6 morewiley +1 more sourceMitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims
Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah +17 morewiley +1 more sourceINO volume 20 issue 1 Back matter [PDF]
, 1966 James Barros, Jacob R. Fishman, Erik H. Erikson, Fredric Solomon, Robert Jay Lifton, Victor Gelineau, David Kantor, William Jones, Margaret Jones, J Veiaut, Tim Millar, Jerry W. Miller, Anthony Ross, Harold Bell, A.M. Godfrey, George Jones, John V. Reynolds, Rex Mortimer, Israel Soebardi, W Getzler +19 moreopenalex +1 more sourceEngineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant
Advanced Science, EarlyView.Engineered neutrophil‐derived vesicles (SOD2‐Fer‐1@CVs) co‐delivering antioxidant and ferroptosis‐inhibitory agents enable inflammation‐targeted, ROS‐responsive therapy for ischemia–reperfusion injury in lung transplantation. Synergizing with ex vivo lung perfusion, this strategy alleviates oxidative stress and inflammation, restores vascular integrity,Hao‐Xiang Yuan, Yu‐Yun Ye, Pu Shen, Jie Zhang, Qian‐Fang Meng, Ying Chen, Xin Xu, Xuan‐Lin Zhang, Lang Rao, Zhi‐Jin Fan, Jian‐Xing He +10 morewiley +1 more sourceVolumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity
Advanced Science, EarlyView.This study provides a volumetric engineered 3D drug reservoir to combat diabetic implant infection. Cu‐doped quantum dots induce cuproptosis‐like bacterial death via metabolic collapse, while glucose oxidase triggers hunger‐triggered mitochondrial protection in host cells.Dize Li, Hongrui Qin, Min Jiang, Hongjiang Wei, Hongyong Zhao, Ping Tang, Guangyu Jian, Henny C van der Mei, Tao Chen +8 morewiley +1 more sourceModulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration
Advanced Science, EarlyView.The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract
Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei +12 morewiley +1 more sourceINO volume 25 issue 1 Cover and Front matter [PDF]
, 1971 John L. Clark, Michael P. O’Leary, Eugene R. Wittkopf, David P. Forsythe, Gary B. Ostrower, Edward Articles, Joan Nelson, Robert Asher, James A. Caporaso, Barry D. Hughes, Carroll L. Wilson, James Phinney Baxter, Robert Emeritus, Louis Bowie, Erwin Cabot, Frank Canham, L. F. Coffin, Eli Cronkhite Emeritus, Leland Goldston, E. P. Goodrich, John Gullion, Bruce Herbert, Joseph Hopper, Milton Johnson, Franklin Katz, George Lindsay, John Cabot Lodge, Calvin Morison, Jerome Plimpton, Paul Preston, Alfred O. Hero, Anita Yurchyshyn, Carolyn Leigh +32 moreopenalex +1 more source
