Results 241 to 250 of about 131,372 (308)

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Folate-modified liposomal celastrol for rheumatoid arthritis: therapeutic efficacy and modulation of ROS/NF-κB/COX-2-related inflammatory signaling. [PDF]

Front Immunol
Shen J, Zhou C, Wang X, Chen Y, Liu R, Hong L, Ji W, Wang B.   +7 more
europepmc   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Preserved Acute Pulmonary Endothelial Homeostasis with Hydrogen Gas Inhalation After Neonatal Hypoxia-Ischemia Despite Increased Neutrophil Accumulation. [PDF]

Biomedicines
Yokota T, Iketani M, Tsuchiya T, Sakamoto K, Nakao Y, Mitsuie T, Inoue E, Inoue K, Kusaka T, Wakabayashi T, Koyano K, Miki T, Ueno M, Nakamura S, Kusaka T.   +14 more
europepmc   +1 more source

Miniaturized Multifunctional Valves for Intelligent Pneumatic Systems in Soft Robotics

Advanced Intelligent Systems, EarlyView.
Miniaturized multifunctional pneumatic valves in normally closed (NC) and normally open (NO) configurations enable reconfigurable and programmable fluidic logic—including AND, OR, NAND, and NOR gates—with/without physical replumbing. These valves integrate sensing, logic, and actuation within a unified architecture, demonstrated through an electronics ...
J. Xu, X. Z. Niu, J. Andersson, D./G. Broo, K. Hjort   +4 more
wiley   +1 more source

Dynamic changes and roles of LYVE-1 during lipopolysaccharide-induced ALI/ARDS in mice. [PDF]

BBA Adv
Matsunaga S, Takamori S, Lin S, Man C, Mizuta Y, Narahara S, Kawano T, Murata M, Akahoshi T.   +8 more
europepmc   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

Exosomal delivery of METTL3 promotes M1 macrophage polarization by inducing miR-155-5p maturation via m6A modification. [PDF]

Ann Med
Wu X, Gong H, Zhang J, Yu L, Yan X, Pan W, Liu C.   +6 more
europepmc   +1 more source

Construction and evaluation of a chronic arthritis animal model induced by persistent activation of toll‐like receptors via lipopolysaccharide stimulation

Animal Models and Experimental Medicine, EarlyView.
We constructed a novel systemic juvenile idiopathic arthritis mouse model (LC) by introducing sustained TLR4 activation into the collagen‐induced arthritis model. The LC model effectively recapitulates human sJIA‐like systemic inflammation while revealing a critical dissociation between systemic immune activation and joint damage.
Fengming Li, Qiang Luo, Xinglin Wu, Yuxiao Chen, Xuemei Tang   +4 more
wiley   +1 more source

Exploring the Differential Impact of Melatonin Timing Administration (Day vs. Night) on Mitigating Cerebellar Damage Caused by Monosodium Glutamate in Rats. [PDF]

J Biochem Mol Toxicol
Ahmad AG, Abd El-Fadeal NM, Arafat HEK, Ahmed DI, Atta R.   +4 more
europepmc   +1 more source