Results 291 to 300 of about 71,261 (330)
Detection of Inosine in Messenger RNA by Inosine-Specific Cleavage [PDF]
Biochemistry, 1997 Double-stranded RNA adenosine deaminases catalyze the conversion of adenosine to inosine within double-stranded RNA. A few candidate biological substrates for these enzymes have been discovered by noticing discrepancies between genomic and cDNA sequences.
Daniel P. Morse, Brenda L. Bass
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Life Science, 2022
Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disease characterized by involuntary bizarre movements, psychiatric symptoms, dementia, and early death.
Marwa El-Shamarka +4 more
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Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disease characterized by involuntary bizarre movements, psychiatric symptoms, dementia, and early death.
Marwa El-Shamarka +4 more
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Advanced Functional Materials, 2022
Inosine is proven to promote the proliferation and function of CD8+ cytotoxic lymphocytes (CD8+ T) under glucose restriction and enhance the efficacy of programmed cell death protein ligand‐1 (PD‐L1) blockade therapy.
J. Qi +8 more
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Inosine is proven to promote the proliferation and function of CD8+ cytotoxic lymphocytes (CD8+ T) under glucose restriction and enhance the efficacy of programmed cell death protein ligand‐1 (PD‐L1) blockade therapy.
J. Qi +8 more
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Molecular and General Genetics MGG, 1988
Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
Patrice L. Nordmann +2 more
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Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
Patrice L. Nordmann +2 more
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract Antibodies against a single minor base, inosine, have been prepared by immunizing rabbits with a conjugate of inosine and bovine serum albumin. The antisera obtained were fairly specific for inosine, only guanosine among the major nucleosides being capable of cross-reacting with them.
Uriel Z. Littauer +3 more
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Abstract Antibodies against a single minor base, inosine, have been prepared by immunizing rabbits with a conjugate of inosine and bovine serum albumin. The antisera obtained were fairly specific for inosine, only guanosine among the major nucleosides being capable of cross-reacting with them.
Uriel Z. Littauer +3 more
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Vasoactivity of inosine in the rat
Pharmacological Research Communications, 1980Summary Inosine increases the blood pressure in the rat independently of the autonomic nervous system. The mechanism of this hypertensive effect was investigated in 18 rats anesthetized with sodium pentobarbital. Inosine (0.01 M) infused at 0.03, 0.06, and 0.08 ml/min into the external jugular vein consistently caused a sustained, dose-dependent rise
Russell L. Prewitt, Jay M. Sullivan
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Molecular Conformation of Inosine
Nature, 1969INOSINE is one of the rare nucleosides found in nucleic acids. It occurs especially in transfer ribonucleic acid where it appears to form part of a number of anticodons1,2. It can form a base pair with any one of the bases adenine, uracil or cytidine in the third codon1,2 position, and the possibility of atypical base pairs is part of the “wobble ...
P. Tollin, A. R. I. Munns
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On the tautomeric structure of inosine
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract The suggestion that 6-keto and 6-enol tautomers of inosine may be of similar stability in neutral aqueous solution has been investigated by means of Raman spectroscopy. Spectra of aqueous solutions of inosine and its methylated analogs were obtained in the region 2000-200 cm−1 using argon laser excitation, and indicate that inosine exists ...
George J. Thomas, G.C. Medeiros
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Renal preservation with inosine
Urology, 1980Isosine improved post-transplantation function of canine kidneys subjected to thirty minutes of normothermic ischemia followed by flushing and twenty-four-hour cold storage. Inosine was not able to improve renal preservation when cold storage was extended to forty-eight hours after thirty minutes of normothermic ischemia.
August J. Maggio +3 more
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The Journal of Chemical Thermodynamics, 2005
Abstract The formation thermodynamic properties of crystalline and aqueous inosine have been determined by using a combination of calorimetric techniques. Oxygen bomb calorimetric measurements on crystalline inosine yielded a standard molar enthalpy of combustion of Δ c H m ∘ = - ( 4802.2 ± 4.5 ) kJ · mol - 1
Robert N. Goldberg +5 more
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Abstract The formation thermodynamic properties of crystalline and aqueous inosine have been determined by using a combination of calorimetric techniques. Oxygen bomb calorimetric measurements on crystalline inosine yielded a standard molar enthalpy of combustion of Δ c H m ∘ = - ( 4802.2 ± 4.5 ) kJ · mol - 1
Robert N. Goldberg +5 more
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