Results 1 to 10 of about 14,182 (164)

Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotides

Scientific Reports, 2022
Inosine triphosphate pyrophosphatases (ITPases) are ubiquitous house-cleaning enzymes that specifically recognize deaminated purine nucleotides and catalyze their hydrolytic cleavage.
Antonio E. Vidal, Miriam Yagüe-Capilla, Blanca Martínez-Arribas, Daniel García-Caballero, Luis M. Ruiz-Pérez, Dolores González-Pacanowska   +5 more
doaj   +3 more sources

RNA editing in cardiovascular health and disease [PDF]

Communications Biology
Post-transcriptional RNA modifications can alter RNA structure, stability, localization, and function. Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional modification that converts adenosine nucleotides in RNA to inosine nucleotides ...
Xiaoxin Huang, Charles Solomon, David G. McVey, Shu Ye   +3 more
doaj   +2 more sources

Mycophenolate mofetil reduces the branching of microglial processes [PDF]

Molecular Brain
Microglia, the resident immune cells in the central nervous system, play important roles not only in immune response but also in neurogenesis, synaptogenesis, and neural circuit formation.
Rin-ichiro Teruya, Kentaro Ueda, Takumi Taketomi, Takushi Yamamoto, Naoki Yamashita, Hana Konno, Fuminori Tsuruta   +6 more
doaj   +2 more sources

A LC-MS/MS Method for Quantifying Adenosine, Guanosine and Inosine Nucleotides in Human Cells. [PDF]

Pharm Res, 2017
To develop and validate a method for the simultaneous measurement of adenosine, guanosine, and inosine derived from mono (MP) and triphosphate (TP) forms in peripheral blood mononuclear cells (PBMCs), red blood cells (RBCs) and dried blood spots (DBS).Solid phase extraction of cell lysates followed by dephosphorylation to molar equivalent nucleoside ...
Jimmerson LC, Bushman LR, Ray ML, Anderson PL, Kiser JJ.   +4 more
europepmc   +4 more sources

An inosine triphosphate pyrophosphatase safeguards plant nucleic acids from aberrant purine nucleotides [PDF]

New Phytologist, 2022
Summary In plants, inosine is enzymatically introduced in some tRNAs, but not in other RNAs or DNA. Nonetheless, our data show that RNA and DNA from Arabidopsis thaliana contain (deoxy ...
Henryk Straube, Jannis Straube, Jannis Rinne, Lisa Fischer, Markus Niehaus, Claus‐Peter Witte, Marco Herde   +6 more
openaire   +3 more sources

O6-[(2″,3″-O-Isopropylidene-5″-O-^tbutyldimethylsilyl)pentyl]-5′-O-^tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine

Molbank, 2022
Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano, Monica Terracciano, Vincenzo Piccialli, Ahmed Mahal, Roberto Nilo, Stefano D’Errico   +5 more
doaj   +1 more source

In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes

Biotechnology for Biofuels and Bioproducts, 2022
Background Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic
Aihua Deng, Qidi Qiu, Qinyun Sun, Zhenxiang Chen, Junyue Wang, Yu Zhang, Shuwen Liu, Tingyi Wen   +7 more
doaj   +1 more source

Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation

Cell Death and Disease, 2023
Metabolic heterogeneity of tumor microenvironment (TME) is a hallmark of cancer and a big barrier to cancer treatment. Cancer cells display diverse capacities to utilize alternative carbon sources, including nucleotides, under poor nutrient circumstances.
Mei-Xin Li, Xiao-Ting Wu, Wen-Qiang Jing, Wen-Kui Hou, Sheng Hu, Wei Yan   +5 more
doaj   +1 more source

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies

Cells, 2022
Inosine triphosphate pyrophosphatase (ITPase) is an enzyme encoded by the ITPA gene and functions to prevent the incorporation of noncanonical purine nucleotides into DNA and RNA.
Mazin A. Zamzami
doaj   +1 more source

Determination of Characteristic Taste Compounds of Crayfish by 1H Nuclear Magnetic Resonance [PDF]

Shipin Kexue, 2023
In order to investigate the nonvolatile taste-active components in crayfish, free amino acids, nucleotides, organic acids, soluble sugars and alkaloids in cooked crayfish muscle were qualitatively and quantitatively analyzed by 1H nuclear magnetic ...
YAO Jingyu, LIU Jie, BAI Xueying, MO Xueying, CHEN Dewei
doaj   +1 more source