Results 1 to 10 of about 7,394 (114)
Inosine in Neurodegenerative Diseases: From the Bench to the Bedside
Molecules, 2022 Neurodegenerative diseases, such as Alzheimer′s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently represent major unmet medical needs. Therefore, novel therapeutic strategies are needed in
Maria Sofia Basile +2 more
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Frontiers in Immunology, 2022 Autoimmune hepatitis (AIH) is an autoimmune disease caused by disruption of liver immune homeostasis. Genetic studies have revealed the predisposition of AIH with the human leukocyte antigen (HLA) region.
Fan Yang +7 more
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Inosine: A bioactive metabolite with multimodal actions in human diseases
Frontiers in Pharmacology, 2022 The nucleoside inosine is an essential metabolite for purine biosynthesis and degradation; it also acts as a bioactive molecule that regulates RNA editing, metabolic enzyme activity, and signaling pathways.
In Soo Kim +5 more
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Cells, 2020 Human subcutaneous fibroblasts (HSCF) challenged with inflammatory mediators release huge amounts of ATP, which rapidly generates adenosine. Given the nucleoside’s putative relevance in wound healing, dermal fibrosis, and myofascial pain, we ...
Carina Herman-de-Sousa +9 more
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Open Biology, 2021 Endonuclease V is highly conserved, both structurally and functionally, from bacteria to humans, and it cleaves the deoxyinosine-containing double-stranded DNA in Escherichia coli, whereas in Homo sapiens it catalyses the inosine-containing single ...
Megumi Endo +4 more
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Molbank, 2022 Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano +5 more
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Structural Probes in Quadruplex Nucleic Acid Structure Determination by NMR
Molecules, 2012 Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleic acid structural studies by NMR. Four-stranded nucleic acid architectures studies increasingly benefit from a plethora of nucleotide conjugates for resonance assignments, the ...
Mateus Webba da Silva +1 more
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Foods, 2020 Currently, soybean meal constitutes the main protein source for poultry production. However, the environmental and social issues related to soybean production are calling for more sustainable protein sources that can offset soybean requirements in animal
Vasiliki Gkarane +3 more
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The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis
eLife, 2017 ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date.
Sarah N Deffit +9 more
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Digital Biomarkers, 2022 Background: Smartphones can generate objective measures of Parkinson’s disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited.
Alex Page +8 more
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