Results 41 to 50 of about 54,859 (243)
A purinergic call to arms from dying brown adipocytes
Cell Stress, 2022 Brown adipocytes react to temperature and nutritional challenges by ramping up their metabolism and generating heat. This adaptation to changes in the environment is crucial for defending organismal homeostasis, but is impaired in obesity and ...
Mohammed K. Hankir
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Advanced Science, EarlyView.Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang +11 more
wiley +1 more source
Advanced Science, EarlyView.The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin +13 more
wiley +1 more source
Біологічні студії, 2012 In experiments on young rat females, it has been established, that the nonsteroid anabolic inosine caused in the case of complex application with dexamethasone the increasing of a specific fraction of slow or intermediate type of fibers in initially ...
V. V. Trush
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A inosina previne alterações comportamentais e bioquímicas induzidas pelo metilmercúrio em camundongos [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2014.Introdução: O metilmercúrio (MeHg) tem sido especulado como contaminante ambiental envolvido em
Macedo Júnior, Sérgio José
core
SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition
Advanced Science, EarlyView.The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang +9 more
wiley +1 more source
Inosina previne a resposta inflamatória e nociceptiva induzida pelo modelo experimental de esclerose múltipla [PDF]
, 2015 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2015.A Esclerose Múltipla (EM) é uma doença autoimune mediada por linfócitos T e caracterizada por ...
Junqueira, Stella Célio
core
Inosine transiently decreases coronary flow but potentiates vasodilation by adenosine
, 1990 To test whether inosine interferes with the action of adenosine, we investigated the effects of intracoronary administration of inosine, adenosine, 8-phenyltheophylline, and adenosine deaminase on isolated rat heart. Inosine did not change heart rate or
J. W. de Jong, P. Van der Meer
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Semi‐Artificial Photosynthesis Enables Light‐Driven Biomanufacturing in Non‐Photosynthetic Bacteria
Advanced Science, EarlyView.A non‐invasive strategy exploits endogenous H2S metabolism in B. subtilis to drive in situ CdS biomineralization, enabling tight bio‐abiotic contact without genetic modification. Light harvested by the biomineralized nanoparticles powers NADPH regeneration, elevating 2’‐fucosyllactose and surfactin titres two‐ to three‐fold.
Jie Zheng +8 more
wiley +1 more source
Xanthine Oxidoreductase: A Double-Edged Sword in Neurological Diseases
AntioxidantsNon-communicable neurological disorders are the second leading cause of death, and their burden continues to increase as the world population grows and ages.
Massimo Bortolotti +3 more
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