Results 21 to 30 of about 44,397 (216)
Association of Inosine and Cytidine
Biophysical Journal, 1971 A rigorous theory for the analysis of an associating system involving two different monomer units, which may also undergo self-association, has been developed. In the present paper the application of the theory to actual data is demonstrated for the first time.
Magar, M.E., Steiner, R.F., Kolinski, R.
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Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors
Frontiers in Immunology, 2017 IntroductionMany antitumor therapies induce apoptotic cell death in order to cause tumor regression. Paradoxically, apoptotic cells are also known to promote wound healing, cell proliferation, and tumor cell repopulation in multicellular organisms.
Yi Zhao +13 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2022 Because, as of yet, there are few new antibiotics active against multidrug-resistant bacteria are being explored, compounds including metabolites that might help us tide over this crisis are greatly expected.
Jian-jun Tao +7 more
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Genotoxicity and mutagenicity of inosine pranobex [PDF]
Journal of Veterinary Research, 2018 Abstract Introduction Inosine pranobex (Methisoprinol, ISO, Isoprinosine) is an immuno-modulatory antiviral drug that has been licensed since 1971 in several countries worldwide. In humans, the drug is approved for the treatment of viral infections, and it might also have therapeutic use in ...
Tobólska Sylwia +3 more
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Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages
MoleculesInosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26
Yuchen Ma +6 more
doaj +1 more source
Current Opinion in Genetics & Development, 2014 Deamination of the nucleobases in DNA and RNA is a result of spontaneous hydrolysis, endogenous or environmental factors as well as deaminase enzymes. Adenosine is deaminated to inosine which is miscoding and preferentially base pairs with cytosine. In the case of DNA, this is a premutagenic event that is counteracted by DNA repair enzymes specifically
Alseth, Ingrun +2 more
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CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Frontiers in MicrobiologyBackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A.
Li Wei +14 more
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Антибиотики и Химиотерапия, 2022 The aim of the study is to evaluate the clinical efficacy, safety, and impact of the complex metabolic neuroprotector on the patients’ quality of life (CMN) Cytoflavin in tablets, as well as in the course of stepwise pharmacotherapy of patients with ...
M. V. Zhuravleva +5 more
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Cancer MedicineBackground This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to ...
Haiqing Zhao +6 more
doaj +1 more source