Results 21 to 30 of about 7,394 (114)

Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors

Frontiers in Immunology, 2017
IntroductionMany antitumor therapies induce apoptotic cell death in order to cause tumor regression. Paradoxically, apoptotic cells are also known to promote wound healing, cell proliferation, and tumor cell repopulation in multicellular organisms.
Yi Zhao, Jin Chen, Jin Chen, Ricardo A. Chaurio, Christian Maueröder, Anja Derer, Manfred Rauh, Andriy Kost, Yi Liu, Xianming Mo, Axel Hueber, Rostyslav Bilyy, Martin Herrmann, Luis E. Muñoz   +13 more
doaj   +1 more source

Bacillus cereus spores release alanine that synergizes with inosine to promote germination. [PDF]

PLoS ONE, 2009
BACKGROUND:The first step of the bacterial lifecycle is the germination of bacterial spores into their vegetative form, which requires the presence of specific nutrients.
Tetyana Dodatko, Monique Akoachere, Stefan M Muehlbauer, Forrest Helfrich, Amber Howerton, Christian Ross, Vicki Wysocki, Jürgen Brojatsch, Ernesto Abel-Santos   +8 more
doaj   +1 more source

A Microtitre Plate Dilution Method for Minimum Killing Concentration Is Developed to Evaluate Metabolites-Enabled Killing of Bacteria by β-lactam Antibiotics

Frontiers in Molecular Biosciences, 2022
Because, as of yet, there are few new antibiotics active against multidrug-resistant bacteria are being explored, compounds including metabolites that might help us tide over this crisis are greatly expected.
Jian-jun Tao, Juan-juan Xiang, Ming Jiang, Su-fang Kuang, Xuan-xian Peng, Xuan-xian Peng, Hui Li, Hui Li   +7 more
doaj   +1 more source

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine [PDF]

, 2022
Brown adipose tissue (BAT) dissipates energy(1,2) and promotes cardiometabolic health(3). Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but not much is known about BAT apoptosis.
Hoffmann, Anne, Krahmer, Natalie, Gnad, T., Müller, Christa E., Heine, M., Eltzschig, H.K., Tönjes, Anke, Blüher, M., Puetz, Laura, Jafari, A., Heeren, J., Schlein, Christian, Blüher, Matthias, Feickert, Martin, Eltzschig, Holger K., Haufs-Brusberg, S., Zurkovic, J., Jaeckstein, Michelle Y, Eltzschig, Holger K, Krahmer, N., Heine, Markus, Heeren, Joerg, Feickert, M., Jaeckstein, M.Y., Pfeifer, A., Niemann, B., Haufs-Brusberg, Saskia, Kovacs, P., Müller, Christa E, Puetz, L., Pfeifer, Alexander, Jafari, Azin, Hoffmann, A., Schlein, C., Gnad, Thorsten, Niemann, Birte, Zurkovic, Jelena, Trautmann, Eva-Maria, Kovacs, Peter, Trautmann, E.-M., Jaeckstein, Michelle Y., Müller, C.E., Tönjes, A.   +42 more
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Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses

Frontiers in Microbiology
BackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A.
Li Wei, Yizhi Pan, Yu Guo, Yin Zhu, Yin Zhu, Haoran Jin, Yingying Gu, Chuanshuang Li, Yaqin Wang, Jingjing Lin, Yongping Chen, Chunhai Ke, Chunhai Ke, Lanman Xu, Lanman Xu   +14 more
doaj   +1 more source

Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study

Cancer Medicine
Background This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to ...
Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li   +6 more
doaj   +1 more source

Structural effects of inosine substitution in telomeric DNA quadruplex

Frontiers in Chemistry
The telomeric DNA, a distal region of eukaryotic chromosome containing guanine-rich repetitive sequence of (TTAGGG)n, has been shown to adopt higher-order structures, specifically G-quadruplexes (G4s).
Ya Ying Zheng, Ya Ying Zheng, Ricky Dartawan, Ricky Dartawan, Yuhan Wu, Yuhan Wu, Chengze Wu, Chengze Wu, Hope Zhang, Hope Zhang, Jeanne Lu, Jeanne Lu, Ashley Hu, Ashley Hu, Sweta Vangaveti, Jia Sheng, Jia Sheng   +16 more
doaj   +1 more source

Meta-analytical evaluation of the clinical efficacy of a complex metabolic neuroprotector in patients with chronic cerebral ischemia

Антибиотики и Химиотерапия, 2022
The aim of the study is to evaluate the clinical efficacy, safety, and impact of the complex metabolic neuroprotector on the patients’ quality of life (CMN) Cytoflavin in tablets, as well as in the course of stepwise pharmacotherapy of patients with ...
M. V. Zhuravleva, G. I. Gorodetskay, T. S. Reznikova, N. S. Vasyukova, V. V. Arkhipov, S. Yu. Serebrova   +5 more
doaj   +1 more source

Loss of Cnot6l Impairs Inosine RNA Modifications in Mouse Oocytes

, 2021
Mammalian oocytes must degrade maternal transcripts through a process called translational mRNA decay, in which maternal mRNA undergoes translational activation, followed by deadenylation and mRNA decay. Once a transcript is translationally activated, it
Lane K. Christenson, Nehemiah S. Alvarez, Pavla Brachova   +2 more
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Inosina previne a resposta inflamatória e nociceptiva induzida pelo modelo experimental de esclerose múltipla [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2015.A Esclerose Múltipla (EM) é uma doença autoimune mediada por linfócitos T e caracterizada por ...
Junqueira, Stella Célio
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