Results 11 to 20 of about 54,859 (243)

Genotoxicity and mutagenicity of inosine pranobex [PDF]

Journal of Veterinary Research, 2018
Abstract Introduction Inosine pranobex (Methisoprinol, ISO, Isoprinosine) is an immuno-modulatory antiviral drug that has been licensed since 1971 in several countries worldwide. In humans, the drug is approved for the treatment of viral infections, and it might also have therapeutic use in ...
Tobólska Sylwia, Terpiłowska Sylwia, Jaroszewski Jerzy, Siwicki Andrzej Krzysztof   +3 more
openaire   +4 more sources

Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages

Molecules
Inosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26
Yuchen Ma, Xiaoli Qian, Qun Yu, Yadan Dong, Jiapeng Wang, Heng Liu, Huai Xiao   +6 more
doaj   +2 more sources

The effect of intraoperative inosine infusion on transplant outcomes in deceased-donor kidney transplant recipients

Renal Failure
Objectives It is unknown when inosine was first employed as a renoprotective agent in the context of kidney transplantation procedures. However, there is no clinical evidence to support a protective role of inosine.
You Luo, Yang Zhang, Zuofu Tang, Jinhua Zhang, Ning Na, Hengjun Xiao   +5 more
doaj   +2 more sources

Inosine Substitutions in RNA Activate Latent GQuadruplexes

, 2021
It is well-accepted that gene expression is heavily influenced by RNA structure. For instance, stem-loops and G-quadruplexes (rG4s) are dynamic motifs in mRNAs that influence gene expression.
Verena Schlösser (11432431), Antoine Cléry, Renato Zenobi (248557), Anneke Brümmer (11432428), Antoine Cléry (11432434), Sven Bergmann (20384), Anneke Brümmer, Adam Pruška, Verena Schlösser, Timo Hagen (6696524), Jonathan Hall, Adam Pruška (7511702), Timo Hagen, Artur Laski, Renato Zenobi, Artur Laski (8361987), Frédéric H.-T. Allain, Frédéric H.-T. Allain (1735885), Jonathan Hall (30104), Sven Bergmann   +19 more
core   +3 more sources

Inosine metabolism in the rat [PDF]

Biochemical Journal, 1982
1. Uptake and subsequent metabolism of purine and ribose moieties was monitored after intravenous administration of doubly labelled inosine. 2. More than 95% was cleared from the plasma within 5 min, and 99% within 20 min. 3. Approx. 50% of the 160 mumol total was rapidly incorporated into liver and kidney.
R J, Sharma, A R, Fernando, J R, Griffiths   +2 more
openaire   +2 more sources

An inosine triphosphate pyrophosphatase safeguards plant nucleic acids from aberrant purine nucleotides [PDF]

, 2022
In plants, inosine is enzymatically introduced in some tRNAs, but not in other RNAs or DNA. Nonetheless, our data show that RNA and DNA from Arabidopsis thaliana contain (deoxy)inosine, probably derived from nonenzymatic adenosine deamination in nucleic ...
Niehaus, Markus, Straube, Henryk, Straube, Jannis, Rinne, Jannis, Witte, Claus‐Peter, Fischer, Lisa, Herde, Marco   +6 more
core   +1 more source

Biosensor measurement of purine release from cerebellar cultures and slices [PDF]

, 2010
We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert, Robert Eason, Dale, Nicholas, Wall, Mark J., Mark Wall, Nicholas Dale   +5 more
core   +1 more source

Inosine, gut microbiota, and cancer immunometabolism

, 2023
This article briefly reviews cancer immunity and the role of gut microbiota in carcinogenesis, followed by an understanding of mechanisms by which inosine is involved in cancer immunometabolism.
Saghazadeh, Amene, Rezaei, Nima, Yaribash, Shakila, Samami, Elham, Aleebrahim-Dehkordi, Elahe, Mohebalizadeh, Mehdi   +5 more
core   +1 more source

A Smartphone Application as an Exploratory Endpoint in a Phase 3 Parkinson’s Disease Clinical Trial: A Pilot Study

Digital Biomarkers, 2022
Background: Smartphones can generate objective measures of Parkinson’s disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited.
Alex Page, Norman Yung, Peggy Auinger, Charles Venuto, Alistair Glidden, Eric Macklin, Larsson Omberg, Michael A. Schwarzschild, E. Ray Dorsey   +8 more
doaj   +1 more source

Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma

Frontiers in Oncology, 2022
Pancreatic ductal adenocarcinoma presents a 5-year overall survival rate of 11%, placing an imperative need for the discovery and application of innovative treatments.
Erika Y. Faraoni, Lincoln N. Strickland, Baylee J. O’Brien, Joseph F. Barraza, Nirav C. Thosani, Curtis J. Wray, Tingting W. Mills, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg   +9 more
doaj   +1 more source