Results 11 to 20 of about 44,397 (216)

O6-[(2″,3″-O-Isopropylidene-5″-O-^tbutyldimethylsilyl)pentyl]-5′-O-^tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine

Molbank, 2022
Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano, Monica Terracciano, Vincenzo Piccialli, Ahmed Mahal, Roberto Nilo, Stefano D’Errico   +5 more
doaj   +1 more source

Inosine metabolism in the rat [PDF]

Biochemical Journal, 1982
1. Uptake and subsequent metabolism of purine and ribose moieties was monitored after intravenous administration of doubly labelled inosine. 2. More than 95% was cleared from the plasma within 5 min, and 99% within 20 min. 3. Approx. 50% of the 160 mumol total was rapidly incorporated into liver and kidney.
R J, Sharma, A R, Fernando, J R, Griffiths   +2 more
openaire   +2 more sources

Structural Probes in Quadruplex Nucleic Acid Structure Determination by NMR

Molecules, 2012
Traditionally, isotope-labelled DNA and RNA have been fundamental to nucleic acid structural studies by NMR. Four-stranded nucleic acid architectures studies increasingly benefit from a plethora of nucleotide conjugates for resonance assignments, the ...
Mateus Webba da Silva, Andreas Ioannis Karsisiotis   +1 more
doaj   +1 more source

Effect of Alternative Protein Feeds on the Content of Selected Endogenous Bioactive and Flavour-Related Compounds in Chicken Breast Meat

Foods, 2020
Currently, soybean meal constitutes the main protein source for poultry production. However, the environmental and social issues related to soybean production are calling for more sustainable protein sources that can offset soybean requirements in animal
Vasiliki Gkarane, Marco Ciulu, Brianne Altmann, Daniel Mörlein   +3 more
doaj   +1 more source

The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

eLife, 2017
ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date.
Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley   +9 more
doaj   +1 more source

A Smartphone Application as an Exploratory Endpoint in a Phase 3 Parkinson’s Disease Clinical Trial: A Pilot Study

Digital Biomarkers, 2022
Background: Smartphones can generate objective measures of Parkinson’s disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited.
Alex Page, Norman Yung, Peggy Auinger, Charles Venuto, Alistair Glidden, Eric Macklin, Larsson Omberg, Michael A. Schwarzschild, E. Ray Dorsey   +8 more
doaj   +1 more source

Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma

Frontiers in Oncology, 2022
Pancreatic ductal adenocarcinoma presents a 5-year overall survival rate of 11%, placing an imperative need for the discovery and application of innovative treatments.
Erika Y. Faraoni, Lincoln N. Strickland, Baylee J. O’Brien, Joseph F. Barraza, Nirav C. Thosani, Curtis J. Wray, Tingting W. Mills, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg, Jennifer M. Bailey-Lundberg   +9 more
doaj   +1 more source

The formation of flavoring characteristics of meat products by changing the chemical composition of food compositions

Теория и практика переработки мяса, 2020
The article presents the results of the study of changes in flavour characteristics when using corrective additives. Monosodium glutamate, ribotide, yeast extract and hydrolysate of vegetable soy protein were used as flavoring additives (FA).
A. N. Ivankin, N. L. Vostrikova, O. N. Krasulya, E. V. Kazakova, A. V. Kulikovskii, A. S. Knyazeva   +5 more
doaj   +1 more source

Impact of Inosine on Chronic Unpredictable Mild Stress-Induced Depressive and Anxiety-Like Behaviors With the Alteration of Gut Microbiota

Frontiers in Cellular and Infection Microbiology, 2021
Current antidepressants do not confer a clear advantage in children and adolescents with major depressive disorder (MDD). Accumulating evidence highlights the potential antidepressant-like effects of inosine on adult MDD, and gut microbiomes are ...
Xueer Liu, Xueer Liu, Xueer Liu, Teng Teng, Teng Teng, Teng Teng, Xuemei Li, Xuemei Li, Xuemei Li, Li Fan, Li Fan, Li Fan, Yajie Xiang, Yajie Xiang, Yajie Xiang, Yuanliang Jiang, Yuanliang Jiang, Kang Du, Kang Du, Yuqing Zhang, Xinyu Zhou, Xinyu Zhou, Peng Xie, Peng Xie, Peng Xie   +24 more
doaj   +1 more source

Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma

Metabolites, 2021
In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling, Nadine Knutti, Franziska Scherr, Jörg Geiger, Juliane Weikert, Michael Rose, Roland Jahns, Uta Ceglarek, André Scherag, Michael Kiehntopf   +9 more
doaj   +1 more source