Results 11 to 20 of about 7,394 (114)
Inosine in Biology and Disease
Genes, 2021 The nucleoside inosine plays an important role in purine biosynthesis, gene translation, and modulation of the fate of RNAs. The editing of adenosine to inosine is a widespread post-transcriptional modification in transfer RNAs (tRNAs) and messenger RNAs
Sundaramoorthy Srinivasan +2 more
core +2 more sources
Inosine Prevents Colorectal Cancer Progression by Inducing M1 Phenotypic Polarization of Macrophages
MoleculesInosine (IS) is a naturally occurring metabolite of adenosine with potent immunomodulatory effects. This study investigates the immunomodulatory effects of inosine, particularly its ability to inhibit the development of colorectal cancer (CRC) cells CT26
Yuchen Ma +6 more
doaj +2 more sources
Inosine, gut microbiota, and cancer immunometabolism
, 2023 This article briefly reviews cancer immunity and the role of gut microbiota in carcinogenesis, followed by an understanding of mechanisms by which inosine is involved in cancer immunometabolism.
Saghazadeh, Amene +5 more
core +1 more source
Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert +5 more
core +1 more source
Inosine Substitutions in RNA Activate Latent GQuadruplexes
, 2021 It is well-accepted that gene expression is heavily influenced by RNA structure. For instance, stem-loops and G-quadruplexes (rG4s) are dynamic motifs in mRNAs that influence gene expression.
Verena Schlösser (11432431) +19 more
core +2 more sources
Frontiers in Oncology, 2022 Pancreatic ductal adenocarcinoma presents a 5-year overall survival rate of 11%, placing an imperative need for the discovery and application of innovative treatments.
Erika Y. Faraoni +9 more
doaj +1 more source
Теория и практика переработки мяса, 2020 The article presents the results of the study of changes in flavour characteristics when using corrective additives. Monosodium glutamate, ribotide, yeast extract and hydrolysate of vegetable soy protein were used as flavoring additives (FA).
A. N. Ivankin +5 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Current antidepressants do not confer a clear advantage in children and adolescents with major depressive disorder (MDD). Accumulating evidence highlights the potential antidepressant-like effects of inosine on adult MDD, and gut microbiomes are ...
Xueer Liu +24 more
doaj +1 more source
Biodegradation of Inosine and Guanosine by Bacillus paranthracis YD01
, 2023 Both inosine and guanosine are precursors of uric acid that may cause the diseases of hyperuricemia and gout in humans. Here, a promising bacterial strain for efficiently biodegrading both inosine and guanosine was successfully isolated from a healthy ...
Qianqian Xu +6 more
core +1 more source
Metabolite Ratios as Quality Indicators for Pre-Analytical Variation in Serum and EDTA Plasma
Metabolites, 2021 In clinical diagnostics and research, blood samples are one of the most frequently used materials. Nevertheless, exploring the chemical composition of human plasma and serum is challenging due to the highly dynamic influence of pre-analytical variation ...
Sven Heiling +9 more
doaj +1 more source