Results 31 to 40 of about 54,859 (243)

Therapeutic value of serum uric acid levels increasing in the treatment of multiple sclerosis [PDF]

Vojnosanitetski Pregled, 2006
Background/Aim. Uric acid was successfully used in both, prevention and treatment of the animal model of multiple sclerosis (MS). Recently it has been shown that inosine, a ribosylated precursor of uric acid, might be used to elevate serum uric acid ...
Tončev Goran
doaj   +1 more source

A randomized pilot trial assessing the reduction of gout episodes in hyperuricemic patients by oral administration of Ligilactobacillus salivarius CECT 30632, a strain with the ability to degrade purines

Frontiers in Microbiology, 2023
IntroductionHyperuricemia and gout are receiving an increasing scientific and medical attention because of their relatively high prevalence and their association with relevant co-morbidities.
Juan M. Rodríguez, Marco Garranzo, José Segura, Belén Orgaz, Rebeca Arroyo, Claudio Alba, David Beltrán, Leónides Fernández   +7 more
doaj   +1 more source

Reduction of Redox Potential Exerts a Key Role in Modulating Gut Microbial Taxa and Function by Dietary Supplementation of Pectin in a Pig Model

Microbiology Spectrum, 2023
Pectin exists in a vast range of plants and has a long history of acting as a functional food additive with potential prebiotic effects on intestinal health.
Rongying Xu, Qiuke Li, Hongyu Wang, Yong Su, Weiyun Zhu   +4 more
doaj   +1 more source

Inosine and D-Mannose Secreted by Drug-Resistant Klebsiella pneumoniae Affect Viability of Lung Epithelial Cells

Molecules, 2022
The antibiotic resistance rates of Klebsiella pneumoniae have been steadily increasing in recent years. Nevertheless, the metabolic features of the drug-resistant Klebsiella pneumoniae and its associated benefits for bacterial pathogenicity are far from ...
Yuhan Zhang, Ziwei Zhou, Wenxuan Xiao, Yuting Tang, Wei Guan, Jiang Wang, Farui Shu, Jiaqi Shen, Shaoyan Gu, Lu Zhang, Qingzhong Wang, Lixin Xie   +11 more
doaj   +1 more source

Inosine in DNA and RNA

Current Opinion in Genetics & Development, 2014
Deamination of the nucleobases in DNA and RNA is a result of spontaneous hydrolysis, endogenous or environmental factors as well as deaminase enzymes. Adenosine is deaminated to inosine which is miscoding and preferentially base pairs with cytosine. In the case of DNA, this is a premutagenic event that is counteracted by DNA repair enzymes specifically
Alseth, Ingrun, Dalhus, Bjørn, Bjørås, Magnar   +2 more
openaire   +2 more sources

“Superwobbling” and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code

Life, 2022
The genetic code evolved around the reading of the tRNA anticodon on the primitive ribosome, and tRNA-34 wobble and tRNA-37 modifications coevolved with the code.
Lei Lei, Zachary Frome Burton
doaj   +1 more source

Symbiotic combination of Akkermansia muciniphila and inosine alleviates alcohol-induced liver injury by modulating gut dysbiosis and immune responses

Frontiers in Microbiology
BackgroundAlcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses the therapeutic potential of combining Akkermansia muciniphila (A.
Li Wei, Yizhi Pan, Yu Guo, Yin Zhu, Yin Zhu, Haoran Jin, Yingying Gu, Chuanshuang Li, Yaqin Wang, Jingjing Lin, Yongping Chen, Chunhai Ke, Chunhai Ke, Lanman Xu, Lanman Xu   +14 more
doaj   +1 more source

Inosine improves neurogenic detrusor overactivity.

, 2015
(A) Representative cystometrograms of rats with transection or compression spinal cord injury that received vehicle (upper panels) or inosine (225 mg/kg, lower panels) i.p. daily for 6 wk, either immediately at the time of injury (left and middle panels)
Debra Franck (284585), Carlos R. Estrada (245910), Larry I. Benowitz (153680), Maryrose P. Sullivan (586879), Yeun Goo Chung (284590), Claire Doyle (821410), Vivian Cristofaro (586878), Duong D. Tu (821411), Joshua R. Mauney (245899), Abhishek Seth (821409), Daniel Kim (491713), Rosalyn M. Adam (245909)   +11 more
core   +1 more source

Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study

Cancer Medicine
Background This study aimed to evaluate whether inosine enhances the efficacy of immune‐checkpoint inhibitors in human malignant solid tumors. Methods This single‐center, prospective, randomized, open‐label study was conducted, from January 2021 to ...
Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li   +6 more
doaj   +1 more source

Structural effects of inosine substitution in telomeric DNA quadruplex

Frontiers in Chemistry
The telomeric DNA, a distal region of eukaryotic chromosome containing guanine-rich repetitive sequence of (TTAGGG)n, has been shown to adopt higher-order structures, specifically G-quadruplexes (G4s).
Ya Ying Zheng, Ya Ying Zheng, Ricky Dartawan, Ricky Dartawan, Yuhan Wu, Yuhan Wu, Chengze Wu, Chengze Wu, Hope Zhang, Hope Zhang, Jeanne Lu, Jeanne Lu, Ashley Hu, Ashley Hu, Sweta Vangaveti, Jia Sheng, Jia Sheng   +16 more
doaj   +1 more source