Results 61 to 70 of about 7,394 (114)

Genotoxicity and mutagenicity of inosine pranobex

, 2018
Inosine pranobex (Methisoprinol, ISO, Isoprinosine) is an immuno-modulatory antiviral drug that has been licensed since 1971 in several countries worldwide.
Terpiłowska Sylwia, Jaroszewski Jerzy, Siwicki Andrzej Krzysztof, Tobólska Sylwia   +3 more
core   +1 more source

An Untargeted Metabolomic Analysis of Lacticaseibacillus (L.) rhamnosus, Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum and Limosilactobacillus (L.) reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus

Microorganisms
Lactic acid bacteria are considered an inexhaustible source of bioactive compounds; indeed, products from their metabolism are known to have immunomodulatory and anti-inflammatory activity.
Luca Spaggiari, Natalia Pedretti, Francesco Ricchi, Diego Pinetti, Giuseppina Campisciano, Francesco De Seta, Manola Comar, Samyr Kenno, Andrea Ardizzoni, Eva Pericolini   +9 more
doaj   +1 more source

Caenorhabditis elegans Predation on Bacillus anthracis: Decontamination of Spore Contaminated Soil with Germinants and Nematodes

Frontiers in Microbiology, 2018
Remediation of Bacillus anthracis-contaminated soil is challenging and approaches to reduce overall spore levels in environmentally contaminated soil or after intentional release of the infectious disease agent in a safe, low-cost manner are needed.
Bettina Schelkle, Young Choi, Leslie W. Baillie, William Richter, Fatih Buyuk, Elif Celik, Morgan Wendling, Mitat Sahin, Theresa Gallagher   +8 more
doaj   +1 more source

Effect of inosine on guinea-pig bronchial muscle

, 1973
Inosine, like other purine derivatives, shows antibronchospastic effects both in vivo and in vitro. Its activity remains in propranololor α-methyl-p-tyrosine-pretreated guinea-pigs, but is prevented by theophylline.
C Bianchi, L Beani, A Bertelli
core   +1 more source

Application of Liquid Chromatography Coupled to Mass Spectrometry for Direct Estimation of the Total Levels of Adenosine and Its Catabolites in Human Blood

Pharmaceuticals
Adenosine is a multifunctional nucleoside with several roles across various levels in organisms. Beyond its intracellular involvement in cellular metabolism, extracellular adenosine potently influences both physiological and pathological processes.
Jakub Šofranko, Peter Mitro, Zora Lazúrová, Martin Jozef Péč, Tomáš Bolek, Renata Péčová, Matúš Dohál, Matej Samoš, Radovan Murín   +8 more
doaj   +1 more source

Germination rates as a function of inosine and spore concentrations.

, 2013
(A) Wild-type B. cereus spores were germinated with increasing inosine concentrations (•). B. cereus spores were also germinated in conditioned supernatants collected 30 min after exposure to increasing inosine concentrations (○).
Ernesto Abel-Santos (371530), Forrest Helfrich (371523), Amber Howerton (371525), Stefan M. Muehlbauer (371521), Tetyana Dodatko (371518), Monique Akoachere (371519), Jürgen Brojatsch (11776), Vicki Wysocki (371529), Christian Ross (371527)   +8 more
core   +1 more source

Effects of inosine on reperfusion injury after cardiopulmonary bypass [PDF]

, 2010
Objective Inosine, a break-down product of adenosine has been recently shown to exert inodilatory and anti-inflammatory properties. Furthermore inosine might be a key substrate of pharmacological post-conditioning.
Karck, Matthias, Matthias Karck, Szabó Gábor Balázs, Seres Leila, Veres, Gábor, Radovits, Tamás, Gábor Veres, Veres Gábor, Horkay Ferenc, Karck Matthias, Szabó Gábor, Tamás Radovits, Gábor Szabó, Horkay, Ferenc, Leila Seres, Radovits Tamás, Seres, Leila, Szabó, Gábor, Ferenc Horkay, Karck M   +19 more
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Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer

Microorganisms
Prostate cancer (PCa) is initially sensitive to androgen deprivation therapy (ADT) but ultimately develops resistance and progresses to castration-resistant prostate cancer (CRPC) with a poor prognosis.
Yao Yu, Leqian Li, Qishen Yang, Jingwen Xue, Benlin Wang, Ming Xie, Wentai Shangguan, Zhangrui Zhu, Peng Wu   +8 more
doaj   +1 more source

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man [PDF]

, 2005
Background/Aims: Degradation of adenine nucleotides to adenosine has been suggested to play a critical role in ischemic preconditioning (IPC). Thus, we questioned in patients undergoing partial hepatectomy whether (i) IPC will increase plasma purine ...
Rau, H. G., Peter, K., Heizmann, O., Volk, A., Martignoni, A., Dugas, Martin, Schauer, R. J., Chouker, A., Messmer, K., Thiel, M.   +9 more
core   +1 more source

Inhibition of UBA6 by inosine augments tumour immunogenicity and responses

, 2022
Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic adaptation, however, the mechanism is not fully known.
Wang, Chaoran, He, Jingquan, Ge, Xiaolu, Yang, Yuqin, Li, Qin, He, Baokun, Sadler, Anthony J, Li, Jikun, Li, Jing, Yu, Liang, Zhang, Lei, Wu, Di, Xu, Dakang, Tian, Xiangjun, Wei, Yuhan, Yu, Di, Gao, Yue, Jiang, Li, Sadler, Anthony J., Yuan, Xiangliang, Jiang, Xiaoyue, Zeng, Ling, Gu, Qisheng   +22 more
core   +1 more source