Results 61 to 70 of about 54,859 (243)
Veterinární Medicína, 2015 Inosine is a naturally occurring purine nucleoside, the effect of which was discovered only in recent decades. It has potential to prevent neuronal and glial death and can stimulate axonal outgrowth. This study evaluated the effect of inosine (400 mg per
V. Ledecky +3 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor +12 more
wiley +1 more source
Inosine treatment decreases TRPV1 immunoreactivity following spinal cord injury.
, 2015 Representative photomicrographs of staining for the C fiber marker TRPV1 (red) in bladders from SCI rats treated with vehicle or inosine or non-surgical controls are shown.
Debra Franck (284585) +11 more
core +1 more source
Epileptic Disorders, EarlyView.Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype–phenotype ...
Burcu Yaman +7 more
wiley +1 more source
Bacillus cereus spores release alanine that synergizes with inosine to promote germination. [PDF]
PLoS ONE, 2009 BACKGROUND:The first step of the bacterial lifecycle is the germination of bacterial spores into their vegetative form, which requires the presence of specific nutrients.
Tetyana Dodatko +8 more
doaj +1 more source
Inosine-Induced Base Pairing Diversity during Reverse Transcription
A-to-I editing catalyzed by adenosine deaminase acting on RNAs impacts numerous physiological and biochemical processes that are essential for cellular functions and is a big contributor to the infectivity of certain RNA viruses.
Sweta Vangaveti (3932504) +3 more
core +1 more source
The evolution and implications of the inosine tRNA modification [PDF]
Ever since the legendary publication by Francis Crick in JMB introducing the wobble hypothesis in 1966, inosine has been a permanent part of molecular biology.
Gulik, P.T.S. (Peter) van der +1 more
core +1 more source
Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue
iNew Medicine, EarlyView.ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao +3 more
wiley +1 more source
, 2017 Adenosine deaminase converts adenosine into inosine. In contrast to adenosine, relatively little attention has been paid to the physiological roles of inosine.
Moro, Stefano +5 more
core +1 more source
Nanoplastics: Methods, Exposure and Effects on Domestic, Farm and Wild Animals
Journal of Applied Toxicology, EarlyView.ABSTRACT Nanoplastics (NPs) are synthetic polymer particles ranging in size from 1 nm to 1 μm that have been identified as a major concern for ecosystems and organisms due to their plethora of negative effects. The aim of this review is to provide a comprehensive overview of the knowledge relating to exposure and effects of NPs in domestic (i.e., farm ...
B. De Felice +8 more
wiley +1 more source