Results 81 to 90 of about 7,394 (114)

Atividade antinociceptiva da inosina em camundongos: participação dos receptores A1 e A2A [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA inosina, um nucleosídeo endógeno, e o primeiro metabolito da adenosina, e e sintetizada atraves da adenosina pela ...
Nascimento, Francisney Pinto do
core  

Inosine: biofunctions and the roles in human diseases

Frontiers in Endocrinology
Inosine, a basic component of purine nucleotide, is mainly seen only as a building block in nucleotide synthesis. It is also a versatile bioactive molecule with diverse biofunctions.
Fangwei Li, Jiawen Zhang, Jiayi Kang, Xuemei Tong, Ping Zhang, Yemin Zhu   +5 more
doaj   +1 more source

Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration

Advanced Science
The role of gut microbiota dysbiosis in systemic lupus erythematosus (SLE) pathogenesis remains elusive. Here, it is shown that fecal microbiota transplantation (FMT) from healthy mice to lupus mice ameliorates lupus‐like symptoms.
Lingyu Gao, Yuhan Zhang, Zhi Hu, Shengwen Chen, Qiaolin Wang, Yong Zeng, Huiqi Yin, Junpeng Zhao, Yijing Zhan, Changxing Gao, Yue Xin, Bing Chen, Stijn van derVeen, Ming Zhao, Deyu Fang, Qianjin Lu   +15 more
doaj   +1 more source

Mechanism of Inosine from Lactiplantibacillus plantarum MWFLp-182-Treated Mice Model in Alleviating D-Galactose-Induced HT-22 Cell Injury via Oxidative and Inflammatory Pathways

Foods
Gut microbial metabolites play a crucial role in modulating cognitive function. In a previous animal study, oral administration of Lactiplantibacillus plantarum MWFLp-182 (L.
Jianbo Tang, Qing Zhao, Hanying Tan, Ni Yang, Qun Yu, Zhiyu Cui, Xiaochun Li, Yanghe Luo, Guangqing Mu, Xiaomeng Wu, Hui Nie   +10 more
doaj   +1 more source

Inosine alleviates colorectal cancer liver metastasis by promoting M1 macrophage polarization and modulating the PI3K/AKT signaling pathway

Frontiers in Immunology
IntroductionColorectal cancer (CRC) represents one of the most common malignancies of the digestive tract, with colorectal cancer liver metastasis (CRLM) constituting a major cause of CRC-related mortality, for which therapeutic options remain limited ...
Yadan Dong, Yuchen Ma, Qun Yu, Zhengmei Shi, Caiyi Wang, Yihao Che, Heng Liu, Desheng Wan, Weizai Shao, Weizai Shao, Huai Xiao   +10 more
doaj   +1 more source

Microwave-assisted selective 5′-O-trityl protection of inosine derivatives

, 2013
The efficient microwave-assisted synthesis of 5′-O-trityl inosine derivatives is described. The reported protocol allows the protection of inosine derivatives in significantly higher yields and shorter reaction times than the standard thermal conditions.
Peréz-Pérez, María-Jesús, Casanova, Elena, Kappe, C. O.   +2 more
core   +1 more source

Comparison of the radioprotective effects of copper chlorophyllin, riboxin, indralin, and the combined use of glutathione and ascorbic acid based on the physiological parameters in mice exposed to fractionated irradiation

Учёные записки Казанского университета: Серия Естественные науки
The radioprotective effects of copper chlorophyllin, riboxin, indralin, and the combined use of glutathione and ascorbic acid were compared in male ICR (CD-1) mice exposed to five daily irradiations at doses of 1.4 or 2.5 Gy, with all compounds ...
L. A. Romodin, A. A. Moskovskij, O. V. Nikitenko, T. M. Bychkova, O. V. Mikenin, D. A. Bocharov, E. D. Rodionova   +6 more
doaj   +1 more source

Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene cluster tmexCD-toprJ

mSystems
Antimicrobial resistance is rapidly increasing worldwide, highlighting the urgent need for pharmaceutical and nonpharmaceutical interventions to tackle different-to-treat bacterial infections.
Fulei Li, Tianqi Xu, Dan Fang, Zhiqiang Wang, Yuan Liu   +4 more
doaj   +1 more source

Inosine reduces inflammation and improves survival in a murine model of colitis

, 2003
Inosine, a naturally occurring purine formed from the breakdown of adenosine, has recently been shown to exert powerful anti-inflammatory effects both in vivo and in vitro. This study evaluated inosine as a potential therapy for colitis.
Szabo, C., F. G. Soriano, Mabley, Jon; id_orcid, Liaudet, L., Mabley, J.G., C. Szabó, Soriano, F.G., A. Marton, Pacher, P., P. Pacher, J. G. Mabley, A. L. Salzman, L. Liaudet, G. Haskó, Hasko, G., Marton, A., Salzman, A.L.   +16 more
core   +1 more source

Preparation, Quality and Purine-lowering Activity of Functional Yak Yoghurt during Storage Period

Shipin gongye ke-ji
In order to develop a purine-reducing functional yak yoghurt, Lactobacillus paracasei 259 and commercial starter was used as the fermentation strain in this experiment.
Xindi YU, Jingya LIU, Xiumei REN, Lianhong CHEN   +3 more
doaj   +1 more source