Results 81 to 90 of about 54,859 (243)
, 2000 Gluco- and ribosylation of the bases of sugar protected inosine and uridine were investigated, obtaining only adducts with beta -configuration at thenew glycosidic carbon; stereospecific insertion of a sugar moiety at the 1-N of inosine was achieved ...
DE NAPOLI, LORENZO +5 more
core +2 more sources
Molecular Biomarkers in Meniere's Disease: A Scoping Review of Current Evidence
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom‐driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology.
Hamza Kamran +3 more
wiley +1 more source
Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus
Pest Management Science, EarlyView.Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano +7 more
wiley +1 more source
Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
, 2022 Anti-cancer immunity and response to immune therapy is influenced by the metabolic states of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic adaptation, however, the mechanism is not fully known.
Wang, Chaoran +22 more
core +1 more source
Rheumatology &Autoimmunity, EarlyView.This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues +6 more
wiley +1 more source
Effect of inosine on guinea-pig bronchial muscle
, 1973 Inosine, like other purine derivatives, shows antibronchospastic effects both in vivo and in vitro. Its activity remains in propranololor α-methyl-p-tyrosine-pretreated guinea-pigs, but is prevented by theophylline.
C Bianchi, L Beani, A Bertelli
core +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Organophosphate esters (OPEs) are found ubiquitously in the environment and exposure to these chemicals has induced behavioral, developmental, and morphological impairments in several model organisms. Yet there is still a lack of understanding of how sub‐lethal exposure disrupts organism function at the molecular‐level, especially for Daphnia ...
Salwa Hajir +4 more
wiley +1 more source
Inosine increases CST contacts onto LPSNs.
, 2013 A. Transverse section of an inosine-treated animal though the cervical enlargement shows position of LPSNs (boxes). B, C. Enlargement of areas in (A) show LPSNs (red) that project to the lumbar enlargement. B', C'.
Larry I. Benowitz (153680) +5 more
core +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Inosine and its methyl derivatives:Occurrence, biogenesis, and function in RNA
, 2022 Inosine is one of the most common post-transcriptional modifications. Since its discovery, it has been noted for its ability to contribute to non-Watson-Crick interactions within RNA.
Lahiri, Ansuman +7 more
core +1 more source