Results 101 to 110 of about 54,859 (243)

Virocell Necromass Provides Limited Plant Nitrogen and Elicits Rhizosphere Metabolites That Affect Phage Dynamics

Plant, Cell &Environment, EarlyView.
ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak, Michelle C. M. van Winden, Thomas V. Harwood, Rachel Neurath, Suzanne M. Kosina, Katherine B. Louie, Matthew B. Sullivan, Simon Roux, Karsten Zengler, Vivek K. Mutalik, Trent R. Northen   +10 more
wiley   +1 more source

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch, Yitzhak Tor, Claudia Höbartner   +2 more
wiley   +2 more sources

Effects of Succinate-Based Antioxidant on in vitro Conversion of Methemoglobin in Oxyhemoglobin

Общая реаниматология, 2018
The purpose of the study — to determine the feasibility of using the succinate-based antioxidant for the in vitro reduction of excessive methemoglobin to oxyhemoglobin in blood.Materials and Methods. Blood sampling was performed in five healthy donors in
A. M. Chernysh, E. K. Kozlova, V. V. Moroz, V. A. Sergunova, O. E. Gudkova, E. A. Manchenko, A. P. Kozlov   +6 more
doaj   +1 more source

Inosine reduces inflammation and improves survival in a murine model of colitis

, 2003
Inosine, a naturally occurring purine formed from the breakdown of adenosine, has recently been shown to exert powerful anti-inflammatory effects both in vivo and in vitro. This study evaluated inosine as a potential therapy for colitis.
Szabo, C., F. G. Soriano, Mabley, Jon; id_orcid, Liaudet, L., Mabley, J.G., C. Szabó, Soriano, F.G., A. Marton, Pacher, P., P. Pacher, J. G. Mabley, A. L. Salzman, L. Liaudet, G. Haskó, Hasko, G., Marton, A., Salzman, A.L.   +16 more
core   +1 more source

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

Glia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom, Shweta Tendulkar, Amber R. Hackett, Amy Strickland, Yurie Sato‐Yamada, Liya Yuan, Wendy Dong, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt   +11 more
wiley   +1 more source

Nerve repair with polylactic acid and inosine treatment enhance regeneration and improve functional recovery after sciatic nerve transection

Frontiers in Cellular Neuroscience
BackgroundFollowing transection, nerve repair using the polylactic acid (PLA) conduit is an effective option. In addition, inosine treatment has shown potential to promote nerve regeneration.
Fellipe Soares dos Santos Cardoso, Guilherme dos Santos Maria, Fernanda Marques Pestana, Ricardo Cardoso, Bruna dos Santos Ramalho, Bruna dos Santos Ramalho, Luiza dos Santos Heringer, Tiago Bastos Taboada, Ana Maria Blanco Martinez, Fernanda Martins de Almeida, Fernanda Martins de Almeida   +10 more
doaj   +1 more source

The inosine conundrum [PDF]

Science-Business eXchange, 2009
A new study of inosine in a rat stroke model gives more impetus for studies in humans. But the path forward is uncertain as Alseres Pharmaceuticals needs a partner to develop the compound in the clinic, where key questions about delivery and the treatment window must be worked out.
openaire   +1 more source

Inosine-induced vasoconstriction is mediated by histamine and thromboxane derived from mast cells

, 1996
Mast cell degranulation has been shown to release products that cause arteriolar constriction. We previously reported that two nucleosides, adenosine and inosine, cause vasoconstriction of isolated hamster cheek pouch arterioles by stimulating ...
R. K. Shepherd, B. R. Duling
core   +1 more source

Remodelling of Skeletal Muscle During Iron Deficiency Anaemia and Recovery After Intravenous Iron Therapy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 6, December 2026.
ABSTRACT Background The global prevalence of iron deficiency anaemia (IDA) is about 25% and even higher in women of reproductive age and children. IDA can impair skeletal muscle by disrupting oxygen utilization, energy production and contractile function. Haematological effects of intravenous (IV) iron therapy in IDA are well studied, but its impact on
Elke Pertler, Sonja A. Wagner, Marlene Panzer, Laura Obholzer, Ylena Sonnenburger, Maria R. Troppmair, Martina Saretto, Benedikt Schaefer, Claudia Manzl, Herbert Oberacher, Bettina Sarg, Klaus Faserl, Stefan Redl, Michael W. Hess, Theresia Telser, Jessica P. Popottnigg, Petra Gronich‐Wondrak, Herbert Tilg, Heinz Zoller   +18 more
wiley   +1 more source

Solid-phase synthesis development of N1-alkyl analogues of cyclic inosine-diphosphate-ribose (cIDPR)

, 2008
Herein we report an efficient solid-phase synthesis of some N1-alkyl-substituted analogs of cyclic inosine-diphosphate-ribose (cIDPR), a mimic of cyclic ADP-ribose (cADPR). CIDPR has been described as an agonist of the cADPR/Ca2+ signalling system.
Giorgia Oliviero, Stefano D'Errico, AMATO, JUSSARA, MAYOL, LUCIANO, Nicola Borbone, D'ERRICO, STEFANO, Luciano Mayol, Jussara Amato, OLIVIERO, GIORGIA, Gennaro Piccialli, PICCIALLI, GENNARO, BORBONE, NICOLA   +11 more
core   +1 more source