Results 121 to 130 of about 54,859 (243)

Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats

, 2010
Inflammatory bowel disease comprises chronic recurrent inflammation of gastrointestinal tract. This study was conducted to investigate inosine, a potent immunomodulator, in 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced chronic model of experimental
Dehpour, A.R., Fakhfouri, G., Rasouli, M.R., Rahimian, R., Daneshmand, A., Mohammadi, H., Mousavizadeh, K., Bahremand, A.   +7 more
core  

A multicenter, international, randomized, single-blind, placebo-controlled study of the efficacy and safety of inosine-nicotinamide-riboflavin-succinic acid in the acute period of traumatic brain injury in adults

Frontiers in Neurology
BackgroundThe combination of inosine, nicotinamide, riboflavin, and succinic acid (INRSA) has previously demonstrated neuroprotective effect. We aimed to study the efficacy and safety of treatment with INRSA in traumatic brain injury (TBI).Materials and ...
Tatiana Kharitonova, Tatiana Bragina, Ekaterina Ivanova, Alexander Savello, Taras Skoromets, Sergey Petrikov   +5 more
doaj   +1 more source

Adenine nucleotide synthesis from inosine during normoxia and after ischaemia in the isolated perfused rat heart

, 1985
[14C]inosine in a range of concentrations of 20 μM to 1 mM was administered-to the isolated perfused rat heart for 30 min. The incorporation of the nucleoside into myocardial adenine nucleotides increased for extracellular concentrations of the ...
J. Aussedat, M. Verdys, A. Rossi
core   +1 more source

Isolation and Mechanistic Characterization of Pediococcus pentosaceus WQ-30 from Kimchi for Efficient In Vitro Purine Nucleoside Degradation Relevant to Hyperuricemia

Foods
Hyperuricemia (HUA) is a metabolic syndrome caused by elevated levels of uric acid (UA) serum, posing a significant threat to human health. Lactic acid bacteria degrade or adsorb UA precursors such as purine nucleosides and metabolites.
Qi Wu, Yibin Wang, Zifu Ni, Zhongke Sun, Siyuan Bai, Le Wang   +5 more
doaj   +1 more source

Rice Root Growth with Increasing in Plant Hormone and Allantoin by Inosine in Nutrient Solution [PDF]

, 2009
The presence of low concentration of inosine in solution in soil has increased the root growth as shown in our previous work. Thus the aim of this work was to clear the mechanism of the inosine-induced enhancement of root growth with emphasis on plant ...
Okazaki, Keiki, Tokuhisa, Dai, Watanabe, Toshihiro, Yokoi, Daisuke, Shinano, Takuro, Osaki, Mitsuru   +5 more
core  

Nucleic Acids Research / Inosine induces context-dependent recoding and translational stalling

, 2019
RNA modifications are present in all classes of RNAs. They control the fate of mRNAs by affecting their processing, translation, or stability. Inosine is a particularly widespread modification in metazoan mRNA arising from deamination of adenosine ...
Hartl, Markus, Amman, Fabian, Licht, Konstantin, Janisiw, Michael P., Anrather, Dorothea, Jantsch, Franz-Michael   +5 more
core   +1 more source

Inosine improves open-field behavior and skilled use of hindlimbs.

, 2013
Behavioral studies were carried out in 2 separate cohorts of rats. General locomotor function was evaluated using the Basso-Beattie-Bresnahan (BBB) scale, whereas fine motor coordination was tested using the ladder rung-walking test, scoring the ...
Larry I. Benowitz (153680), Colleen Schaffling (491716), Peng Liang (491715), Daniel Kim (491713), Laila Zai (491714), David Ahlborn (491717)   +5 more
core   +1 more source

Evaluation of Serum Inosine, Hypoxanthine, and Carnitine as Ischemia Markers of Heart Disease [PDF]

Journal of Basic Research in Medical Sciences
Introduction: Heart disease (HD) is a major global death cause, with adenosine triphosphate metabolites, carnitine, and other biomarkers aiding in timely detection and disease prediction.
Hossein Nikpour, Ali Seidkhani-Nahal, Samad Golshani, Gholam Basati   +3 more
doaj  

Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock [PDF]

, 2000
Extracellular purines, including adenosine and ATP, are potent endogenous immunomodulatory molecules. Inosine, a degradation product of these purines, can reach high concentrations in the extracellular space under conditions associated with cellular ...
Szabo, C., Mabley, Jon; id_orcid, Nemeth, Z.H., Kuhel, D.G., Stachlewitz, Robert F., Hasko, G., Southan, G.J., Virag, L., Salzman, A.L., Lohinai, Z.   +9 more
core  

Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury

iMeta
Emerging evidence has demonstrated the profound impact of the gut microbiome on cardiovascular diseases through the production of diverse metabolites. Using an animal model of myocardial ischemia–reperfusion (I/R) injury, we found that the prophylactic ...
Hao Zhang, Jiawan Wang, Jianghua Shen, Siqi Chen, Hailong Yuan, Xuan Zhang, Xu Liu, Ying Yu, Xinran Li, Zeyu Gao, Yaohui Wang, Jun Wang, Moshi Song   +12 more
doaj   +1 more source