Results 71 to 80 of about 54,859 (243)

Effects of mixed microbial fermentation on the quality and metabolite profile of cassava leaf feed based on untargeted metabolomics

JSFA reports, EarlyView.
Abstract Background Cassava leaves are a major byproduct of cassava processing and have a low utilization rate. In this study, Lactiplantibacillus plantarum, Saccharomyces cerevisiae, and Bacillus subtilis were used for solid‐state fermentation of cassava leaves to improve their feed quality. Results After 48 h of fermentation, the feed pH decreased to
Mengjun Zhou, Dongxiu Wang, jie Zhang, Jian Chen, Xuding Wen   +4 more
wiley   +1 more source

An Untargeted Metabolomic Analysis of Lacticaseibacillus (L.) rhamnosus, Lactobacillus (L.) acidophilus, Lactiplantibacillus (L.) plantarum and Limosilactobacillus (L.) reuteri Reveals an Upregulated Production of Inosine from L. rhamnosus

Microorganisms
Lactic acid bacteria are considered an inexhaustible source of bioactive compounds; indeed, products from their metabolism are known to have immunomodulatory and anti-inflammatory activity.
Luca Spaggiari, Natalia Pedretti, Francesco Ricchi, Diego Pinetti, Giuseppina Campisciano, Francesco De Seta, Manola Comar, Samyr Kenno, Andrea Ardizzoni, Eva Pericolini   +9 more
doaj   +1 more source

INOSINE FERMENTATION-PRODUCTION OF INOSINE BY MUTANTS OF BACILLUS SUBTILIS

The Journal of General and Applied Microbiology, 1968
Using rab values, rates of oxygen transfer into sulfite solution, as an index for establishing aeration-agitation, the fermentative production of inosine was scaled up from a flask culture to a 50-k1 tank culture. By applying the optimum condition for the production of inosine obtained with small scale fermentors, the yield of inosine obtained with a ...
RYOHEI AOKI, YASUHIRO KONDO, YOSHIO HIROSE, HIROSHI OKADA   +3 more
openaire   +2 more sources

Site-specific isotope-labeling of inosine phosphoramidites and NMR analysis of an inosine-containing RNA duplex.

, 2016
Structural features and internal dynamics of inosine-containing RNAs are poorly understood. NMR studies of such RNAs require 13C,15N-labeling, which cannot be achieved using in vitro transcription as inosine and guanosine are not distinguished by RNA ...
Michael Sattler, Rübbelke, M., Carell, T., Martin Rübbelke, Beribisky, A.V., Schiesser, S., Alexander V. Beribisky, Dallmann, A., Gnerlich, F., Thomas Carell, Sattler, M., Andre Dallmann, Stefan Schiesser, Felix Gnerlich   +13 more
core   +1 more source

Metabolomic insights for the authentication and traceability of antibiotic‐free pork: a pilot study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Antibiotic‐free production within the meat supply chain is a source of concern since new voluntary label claims need to be authenticated to prevent fraud. Therefore, an untargeted 1H NMR‐based metabolomics approach coupled to unsupervised (principal component analysis) and supervised (orthogonal partial least squares discriminant ...
Maria Olga Varrà, Maria Pia Fabrile, Sergio Ghidini, Augusta Caligiani, Federico Scali, Veronica Lolli, Giovanni Loris Alborali, Adriana Ianieri, Emanuela Zanardi   +8 more
wiley   +1 more source

Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective

Frontiers in Immunology
IntroductionMultiple myeloma (MM) develops within a profoundly immunosuppressive bone marrow (BM) microenvironment. CD38, a multifunctional ectoenzyme highly expressed on malignant plasma cells, contributes to this niche by degrading nicotinamide adenine
Alberto L. Horenstein, Alberto L. Horenstein, Alberto L. Horenstein, Kristine A. Frerichs, Kristine A. Frerichs, Angelo C. Faini, Niels W. C. J. van de Donk, Niels W. C. J. van de Donk, Fabio Malavasi, Fabio Malavasi, Fabio Malavasi   +10 more
doaj   +1 more source

Application of Liquid Chromatography Coupled to Mass Spectrometry for Direct Estimation of the Total Levels of Adenosine and Its Catabolites in Human Blood

Pharmaceuticals
Adenosine is a multifunctional nucleoside with several roles across various levels in organisms. Beyond its intracellular involvement in cellular metabolism, extracellular adenosine potently influences both physiological and pathological processes.
Jakub Šofranko, Peter Mitro, Zora Lazúrová, Martin Jozef Péč, Tomáš Bolek, Renata Péčová, Matúš Dohál, Matej Samoš, Radovan Murín   +8 more
doaj   +1 more source

Functional Roles of Adenosine A2B and A3 Receptor Subtypes in the Bladder of Male Rats With A2B Receptor Deletion or Bladder Outlet Obstruction

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose To investigate the adenosine receptor (AR) mechanism underlying bladder outlet obstruction (BOO)‐related bladder dysfunction, we examined the expression level of AR subtypes in bladder tissues, and the effects of AR subtypes A2B & A3 modulation on bladder activity using male BOO rats, and Dahl rats with A2B receptor deletion. Materials
Masahiro Kurobe, Ei‐ichiro Takaoka, Kanako Matsuoka, Shingo Kimura, Anne M. Robertson, Edwin K. Jackson, Lori A. Birder, Minoru Miyazato, Naoki Yoshimura   +8 more
wiley   +1 more source

Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer

Microorganisms
Prostate cancer (PCa) is initially sensitive to androgen deprivation therapy (ADT) but ultimately develops resistance and progresses to castration-resistant prostate cancer (CRPC) with a poor prognosis.
Yao Yu, Leqian Li, Qishen Yang, Jingwen Xue, Benlin Wang, Ming Xie, Wentai Shangguan, Zhangrui Zhu, Peng Wu   +8 more
doaj   +1 more source

Therapeutic Impact of GLP‐1 Receptor Agonists on Parkinson's Disease: A Scoping Review

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT No disease‐modifying treatment exists for Parkinson's disease (PD). Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have gained attention as promising candidates for neuroprotection, given documented expression of GLP‐1 receptors within the central nervous system and the contribution of brain insulin resistance to dopaminergic ...
João Pedro Henriques, João Pedro Stringhetta Rahal, Rafael da Cunha Gomes Ribeiro, Enzo Bogucheski Ribeiro Machado, Carlos Antonio Negrato   +4 more
wiley   +1 more source