Results 71 to 80 of about 7,394 (114)

Aging increases adenosine and inosine release by human fibroblast cultures

, 2008
The effect of in vitro age and donor age on net release of adenosine and inosine was studied in cultures of normal human fibroblasts. Confluent cultures of low-(population doubling level [PDL] 23-25) and high- (PDL 43-45) passage human lung fibroblasts ...
Dobson, James G. Jr., Ethier, Michael F., Hickler, Roger B.   +2 more
core   +1 more source

Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective

Frontiers in Immunology
IntroductionMultiple myeloma (MM) develops within a profoundly immunosuppressive bone marrow (BM) microenvironment. CD38, a multifunctional ectoenzyme highly expressed on malignant plasma cells, contributes to this niche by degrading nicotinamide adenine
Alberto L. Horenstein, Alberto L. Horenstein, Alberto L. Horenstein, Kristine A. Frerichs, Kristine A. Frerichs, Angelo C. Faini, Niels W. C. J. van de Donk, Niels W. C. J. van de Donk, Fabio Malavasi, Fabio Malavasi, Fabio Malavasi   +10 more
doaj   +1 more source

Inosine increases CST contacts onto LPSNs.

, 2013
A. Transverse section of an inosine-treated animal though the cervical enlargement shows position of LPSNs (boxes). B, C. Enlargement of areas in (A) show LPSNs (red) that project to the lumbar enlargement. B', C'.
Larry I. Benowitz (153680), Colleen Schaffling (491716), Peng Liang (491715), Daniel Kim (491713), Laila Zai (491714), David Ahlborn (491717)   +5 more
core   +1 more source

Structural and functional effects of inosine modification in mRNA [PDF]

Inosine (I), resulting from the deamination of adenosine (A), is a prominent modification in the human transcriptome. The enzymes responsible for the conversion of adenosine to inosine in human mRNAs are the ADARs (adenosine deaminases acting on RNA ...
Beal, Peter A, Mendoza, Herra G
core   +1 more source

OCCURRENCE OF INOSINE KINASE AS A DISTINCT ENZYME IN SPIRULINA PLATENSIS

, 1995
Among a series of purine nucleosides, inosine was found to be phosphorylated at the highest rate by crude extracts of the cyanobacterium Spirulina platensis. The inosine phosphorylating activity could be separated from hypoxanthine-guanine phosphoribosyl
BARSACCHI, Daniela, Ipata PL, IPATA P. L., Barsacchi D., TOZZI M. G., Trinei M, SCOLOZZI C., TRINEI M., Gualerzi C, GUALERZI C., TOZZI, MARIA GRAZIA, Scolozzi C   +11 more
core   +1 more source

Profiles of Streptococcus thermophilus MN‐ZLW‐002 nutrient requirements in controlled pH batch fermentations

MicrobiologyOpen, 2019
This study aimed to evaluate the profiles of Streptococcus thermophilus nutrient requirements to guide the design of media for high cell density culturing. The growth kinetics, physiological state, and nutrient requirement profiles of S.
Gefei Liu, Yali Qiao, Yanjiao Zhang, Cong Leng, Jiahui Sun, Hongyu Chen, Yan Zhang, Aili Li, Zhen Feng   +8 more
doaj   +1 more source

SYNTHETIC INOSINE ANALOGS IN TREATMENT OF CIN IIII

, 2010
Genes products of human papillomavirus (HPV) have been identified in more then 99,7% of cervical carcinomas. Several factors may be associated with higher rates of surgical treatment failure, including highgrade CIN, large lesion size, satellite ...
E V Kozhurina, N S Wanke, A G Kedrova, S A Levakov   +3 more
core   +1 more source

Codon decoding by orthogonal tRNAs interrogates the in vivo preferences of unmodified adenosine in the wobble position

Frontiers in Genetics
The in vivo codon decoding preferences of tRNAs with an authentic adenosine residue at position 34 of the anticodon, the wobble position, are largely unexplored because very few unmodified A34 tRNA genes exist across the three domains of life.
Margaret A. Schmitt, Jillyn M. Tittle, John D. Fisk   +2 more
doaj   +1 more source

Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac ischemia/reperfusion injury

iMeta
Emerging evidence has demonstrated the profound impact of the gut microbiome on cardiovascular diseases through the production of diverse metabolites. Using an animal model of myocardial ischemia–reperfusion (I/R) injury, we found that the prophylactic ...
Hao Zhang, Jiawan Wang, Jianghua Shen, Siqi Chen, Hailong Yuan, Xuan Zhang, Xu Liu, Ying Yu, Xinran Li, Zeyu Gao, Yaohui Wang, Jun Wang, Moshi Song   +12 more
doaj   +1 more source

Inhibition of inosine metabolism of the gut microbiota decreases testosterone secretion in the testis

mSystems
Growing evidence indicates that gut microbiota is involved in the regulation of the host’s sex hormone levels, such as through interfering with the sex hormone metabolism in the intestine.
Lei Tang, Xizhong Yang, Mengting Zhou, Lingxin Feng, Cuijie Ji, Jie Liang, Bei Zhang, Ruowu Shen, Luoyang Wang   +8 more
doaj   +1 more source