Results 131 to 140 of about 14,200 (182)
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Nucleosides, Nucleotides & Nucleic Acids, 2020
A facile, straightforward, reliable, and an efficient chemical synthesis of inosine nucleotides such as 7-methylinosine 5'-O-monophosphate, 7-methylinosine 5'-O-diphosphate, and 7-methylinosine 5'-O-triphosphate, starting from the corresponding inosine nucleotide is delineated.
Annamalai, Senthilvelan +2 more
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A facile, straightforward, reliable, and an efficient chemical synthesis of inosine nucleotides such as 7-methylinosine 5'-O-monophosphate, 7-methylinosine 5'-O-diphosphate, and 7-methylinosine 5'-O-triphosphate, starting from the corresponding inosine nucleotide is delineated.
Annamalai, Senthilvelan +2 more
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Inosine incorporation into myocardial nucleotides
Journal of Molecular and Cellular Cardiology, 1972Abstract Inosine and hypoxanthine, degradative products of adenine nucleotides are released and also taken up by the heart. In order to determine whether inosine can be incorporated into adenine nucleotides by direct phosphorylation or whether initial degradation to hypoxanthine is necessary, isolated guinea pig hearts were perfused with non ...
V T, Wiedmeier, R, Rubio, R M, Berne
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An efficient protection-free chemical synthesis of inosine 5'-nucleotides
Nucleosides, Nucleotides & Nucleic Acids, 2020A facile, straightforward, reliable, and efficient chemical synthesis of inosine nucleotides such as inosine-5'-monophosphate, inosine-5'-diphosphate, and inosine-5'-triphosphate, starting from inosine is delineated. The inosine-5'-monophosphate is achieved by the highly regioselective monophosphorylation of inosine using the Yoshikawa procedure.
Annamalai, Senthilvelan +2 more
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Raman spectroscopic determination of inosine nucleoside in nucleotides
Talanta, 1999Raman spectroscopy has been applied to the analytical determination of inosine nucleoside in nucleotides. Spectral characteristics of aqueous solutions of lithium, potassium and magnesium salts of inosine 5'-monophosphoric acid are described. Two characteristic bands located at 1553 and 1593 cm(-1) whose frequencies are not sensitive either to the ...
R, Escobar +3 more
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European Journal of Pharmacology, 2006
Inosine is absorbed via a N1 transporter that is selective for purine nucleosides. It is conceivable that inosine and inosinic acid might affect the intestinal absorption of mizoribine, an imidazole nucleoside that inhibits the de novo production pathway of guanine ribonucleotide.
Makoto, Okada +4 more
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Inosine is absorbed via a N1 transporter that is selective for purine nucleosides. It is conceivable that inosine and inosinic acid might affect the intestinal absorption of mizoribine, an imidazole nucleoside that inhibits the de novo production pathway of guanine ribonucleotide.
Makoto, Okada +4 more
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Analysis of adenine and inosine nucleotides
Analytica Chimica Acta, 1957Abstract Different methods are described for the separation and determination of adoninc, hypoxanthine, adenosine, inoaineandtheir phosphorylated derivatives, and inorganic ortho-and pyrophosphatc: i) chromatographie procedures on paper, cellulose powder column and paper roll, 2) electrophurctic procedures on paper and cellulose powder column.
P. Cerletti, P.L. Ipata, N. Siliprandi
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Inhibition of inosinic acid dehydrogenase by 6-chloropurine nucleotide
Biochemical Pharmacology, 1969Abstract The inactivation of IMP dehydrogenase of sarcoma 180 ascites tumor cells by 6-chloroinosine 5'-phosphate (ClIMP) has been examined. In the absence of substrates the inhibition of enzymatic activity by this purine nucleotide analog is progressive with time and is not reversed by dialysis.
J H, Anderson, A C, Sartorelli
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Guanine and inosine nucleotides/nucleosides suppress murine T cell activation
Biochemical and Biophysical Research Communications, 2018Damaged tissues and cells release intracellular purine nucleotides, which serve as intercellular signaling factors. We previously showed that exogenously added adenine nucleotide (250 μM ATP) suppressed the activation of murine splenic T lymphocytes. Here, we examined the effects of other purine nucleotides/nucleosides on mouse T cell activation. First,
Yuria, Shinohara, Mitsutoshi, Tsukimoto
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Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides
Journal of Medicinal Chemistry, 1981A series of 8-substituted derivatives of adenosine monophosphate (AMP) and inosine monophosphate (IMP) were synthesized and examined for their ability to inhibit Escherichia coli IMP dehydrogenase. All compounds studied were competitive inhibitors in IMP-dependent competition studies and lacked substrate activity.
E B, Skibo, R B, Meyer
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