Results 141 to 150 of about 14,200 (182)
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Biochemical Pharmacology, 1980
Abstract A purified bovine brain cyclic nucleotide phosphodiesterase catalyzed the hydrolysis of both cyclic AMP and cyclic GMP. Alternative substrate inhibition experiments indicated that cyclic AMP and cyclic GMP were hydrolyzed by the same enzyme and that they shared a common binding site.
C M, Liang, Y P, Liu, B A, Chabner
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Abstract A purified bovine brain cyclic nucleotide phosphodiesterase catalyzed the hydrolysis of both cyclic AMP and cyclic GMP. Alternative substrate inhibition experiments indicated that cyclic AMP and cyclic GMP were hydrolyzed by the same enzyme and that they shared a common binding site.
C M, Liang, Y P, Liu, B A, Chabner
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Breakdown of adenosine and inosine nucleotides in bone at physiological pH
Biochimica et Biophysica Acta, 1959Abstract The breakdown of adenosine and inosine nucleotides and nucleotides have been studied in articular and epiphyseal cartilage, epiphyseal and metaphyseal cancellous bone, diaphyseal compact bone and periosteum. Dephosphorylating, deaminating, aminating and adenylate-kinase activities have been demonstrated.
P, CERLETTI, P L, IPATA, G, TANCREDI
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Helvetica Chimica Acta, 1999
The template-directed oligomerization of nucleoside-5'-phosphoro-2-methyl imidazolides on standard oligonucleotide templates has been studied extensively. Here, we describe experiments with templates in which inosinic acid (I) is substituted for guanylic acid, or 2,6-diaminopurine nucleotide (D) for adenylic acid. We find that the substitution of I for
I A, Kozlov, L E, Orgel
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The template-directed oligomerization of nucleoside-5'-phosphoro-2-methyl imidazolides on standard oligonucleotide templates has been studied extensively. Here, we describe experiments with templates in which inosinic acid (I) is substituted for guanylic acid, or 2,6-diaminopurine nucleotide (D) for adenylic acid. We find that the substitution of I for
I A, Kozlov, L E, Orgel
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The Plant Cell, 2022
AbstractIn nucleotide metabolism, nucleoside kinases recycle nucleosides into nucleotides—a process called nucleoside salvage. Nucleoside kinases for adenosine, uridine, and cytidine have been characterized from many organisms, but kinases for inosine and guanosine salvage are not yet known in eukaryotes and only a few such enzymes have been described ...
Xiaoguang Chen +3 more
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AbstractIn nucleotide metabolism, nucleoside kinases recycle nucleosides into nucleotides—a process called nucleoside salvage. Nucleoside kinases for adenosine, uridine, and cytidine have been characterized from many organisms, but kinases for inosine and guanosine salvage are not yet known in eukaryotes and only a few such enzymes have been described ...
Xiaoguang Chen +3 more
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Clinical Science, 1982
1. AMP, ADP, ATP, IMP, GDP, GTP and adenylosuccinate have been measured by high pressure liquid chromatography in three types of animal muscular dystrophy and in a human patient with Duchenne muscular dystrophy. 2. Abnormalities in nucleotide content varied from one dystrophy to another. 3. In each case, however, the ratio
R J, Shuttlewood, J R, Griffiths
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1. AMP, ADP, ATP, IMP, GDP, GTP and adenylosuccinate have been measured by high pressure liquid chromatography in three types of animal muscular dystrophy and in a human patient with Duchenne muscular dystrophy. 2. Abnormalities in nucleotide content varied from one dystrophy to another. 3. In each case, however, the ratio
R J, Shuttlewood, J R, Griffiths
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Archives of Biochemistry and Biophysics, 1990
In the present study, we attempted to identify the chemical nature of the clastogenic factor (CF) from patients with progressive systemic sclerosis (scleroderma). Computerized mass spectrometry of clastogenic fractions obtained by HPLC of plasma ultrafiltrates detected molecular peaks compatible with inosine triphosphate and inosine diphosphate (ITP ...
C, Auclair +3 more
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In the present study, we attempted to identify the chemical nature of the clastogenic factor (CF) from patients with progressive systemic sclerosis (scleroderma). Computerized mass spectrometry of clastogenic fractions obtained by HPLC of plasma ultrafiltrates detected molecular peaks compatible with inosine triphosphate and inosine diphosphate (ITP ...
C, Auclair +3 more
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ChemInform Abstract: INHIBITION OF INOSINIC ACID DEHYDROGENASE BY 8‐SUBSTITUTED PURINE NUCLEOTIDES
Chemischer Informationsdienst, 1982AbstractDie Bromide (I) werden direkt oder über die Mercaptoverbindungen (III) in die Thio‐ Verbindungen (II) umgewandelt.
E. B. SKIBO, R. B. JUN. MEYER
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Some new complexes of Co(III) with hypoxanthine, inosine and purine nucleotides
Inorganica Chimica Acta, 1987Abstract Co(III) complexes with 5′-IMP, 5′-GMP, 5′-AMP, inosine and hypoxanthine were prepared by reaction of trans -[Co(en) 2 Cl 2 ]Cl with the nucleotide, nucleoside and the base in water medium. The complexes were characterized by their elemental analysis, conductivity, UV, NMR and IR data.
D. Mulet +4 more
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EPAI-NC: Enhanced prediction of adenosine to inosine RNA editing sites using nucleotide compositions
Analytical Biochemistry, 2019RNA editing process like Adenosine to Intosine (A-to-I) often influences basic functions like splicing stability and most importantly the translation. Thus knowledge about editing sites is of great importance in molecular biology. With the growth of known editing sites, machine learning or data centric approaches are now being applied to solve this ...
Ahsan Ahmad, Swakkhar Shatabda
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Biochemical Pharmacology, 1969
Abstract IMP dehydrogenase of sarcoma 180 ascites tumor cells is inhibited in a competitive manner by the guanine nucleotide biosynthetic pathway end-product GMP. The effectiveness of IMP as a substrate and of GMP as an inhibitor was mimicked less strongly by dIMP and dGMP, as well as by the corresponding nucleoside di- and triphosphate compounds.
J H, Anderson, A C, Sartorelli
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Abstract IMP dehydrogenase of sarcoma 180 ascites tumor cells is inhibited in a competitive manner by the guanine nucleotide biosynthetic pathway end-product GMP. The effectiveness of IMP as a substrate and of GMP as an inhibitor was mimicked less strongly by dIMP and dGMP, as well as by the corresponding nucleoside di- and triphosphate compounds.
J H, Anderson, A C, Sartorelli
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