Results 311 to 320 of about 270,142 (371)

PI3Kγ in Tumour Inflammation: Bridging Immune Response and Cancer Progression—A Mini‐Review

open access: yesImmunology, EarlyView.
Myeloid cell PI3Kγ can be activated by G Protein‐Coupled Receptors or Receptor Tyrosine Kinases. Once activated, PI3Kγ promotes integrin activation as well as Akt and mTOR activation, thereby promoting transcription of immune‐suppressive and pro‐angiogenic factors, such as Arginase, IL‐10, TGFβ and VEGF‐A.
Anghesom Ghebremedhin, Judith A. Varner
wiley   +1 more source

A SlMYB78‐regulated bifunctional gene cluster for phenolamide and salicylic acid biosynthesis during tomato domestication, reducing disease resistance

open access: yesJournal of Integrative Plant Biology, EarlyView.
The tomato transcription factor SlMYB78 controls a key metabolic gene cluster including ENHANCED PSEUDOMONAS SUSCEPTIBILTY 1, encoding a key enzyme that produces disease‐fighting compounds (phenolamides) and immune signals (salicylic acid). During domestication, tomatoes lost a superior variant (SlEPS1HapB), weakening disease resistance; restoring this
Peng Cao   +14 more
wiley   +1 more source

Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control

open access: yesJournal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP‐producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re‐evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r.
Limei Zhang   +7 more
wiley   +1 more source

Hypotheses in light detection by vertebrate ancient opsin in the bird brain

open access: yesJournal of Neuroendocrinology, EarlyView.
Abstract Extra‐retinal photoreception is common across fish and avian species. In birds, the hypothalamus contains non‐visual photoreceptors that detect light and regulate multiple endocrine systems. To date, light‐dependent control of seasonal reproduction is one of the most well‐studied systems that require deep brain photoreception.
Tyler J. Stevenson   +6 more
wiley   +1 more source

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

open access: yes
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Expression patterns of melanin‐related genes are linked to crypsis and conspicuousness in a pumpkin toadlet

open access: yesMolecular Ecology, EarlyView.
Abstract Colour signals play pivotal roles in different communication systems, and the evolution of these characters has been associated with behavioural ecology, integumentary production processes and perceptual mechanisms of the species involved. Here, we present the first insight into the molecular and histological basis of skin colour polymorphism ...
Juliane P. C. Monteiro   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy