Results 41 to 50 of about 270,142 (371)

Physics-based machine learning for modeling stochastic IP3-dependent calcium dynamics [PDF]

arXiv, 2021
We present a machine learning method for model reduction which incorporates domain-specific physics through candidate functions. Our method estimates an effective probability distribution and differential equation model from stochastic simulations of a reaction network.
arxiv  

Inositol Pyrophosphate Pyrotechnics [PDF]

Cell Metabolism, 2007
Physiologic roles of highly phosphorylated inositol phosphates, including those containing pyrophosphate groups, have been the focus of much recent interest. In the April 6, 2007 issue of Science, two papers (Lee et al., 2007; Mulugu et al., 2007) demonstrate the occurrence of a novel inositol pyrophosphate molecule in yeast and elucidate its role in ...
Solomon H. Snyder, Anutosh Chakraborty, Rashna Bhandari   +2 more
openaire   +3 more sources

Inhibitors of Inositol Monophosphatase [PDF]

Journal of Enzyme Inhibition, 1999
Inositol monophosphatase (IMPase) catalyses the hydrolysis of myo-inositol monophosphates to myo-inositol, which is required in the phosphatidyl inositol cell signalling pathway. Here the enzyme structure, mechanism and inhibition of IMPase are reviewed. Lithium, an effective therapy for manic depression, is an uncompetitive inhibitor.
Fauroux, Christine M J, Freeman, Sally
openaire   +4 more sources

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]

Proceedings of the National Academy of Sciences, 2001
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
Akira Sawa, Adele M. Snowman, Xiaojiang Luo, Solomon H. Snyder, Hongbo R. Luo, Eiichiro Nagata, Adolfo Saiardi   +6 more
openaire   +3 more sources

An amphitropic cAMP-binding protein in yeast mitochondria [PDF]

, 1989
: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol.
Bandlow W., Baranska J., Blok M., Brugge J., Burn P., Burn P., Cascales S. C., Cobon G. S., Cobon G. S., Cornell R., Courtneidge S. A., Cross G. A. M., Dils R. R., Dygas A., Gillfillan A. M., Guarnieri M., Hixson C. S., Hostetler K. Y., Jelsema C. L., Kraft A. S., Lassing I., Lassing I., Low M. G., Megli F. M., Meyer R. K., Muller G., Muller G., Muller G., Muller G., Nishizuka Y., Pelech S. L., Radika R., Rodel G., Rotman A., Schmidt M. F. G., Sefton B. M., Sleight R., Terce F., Towbin H., Wirtz K. W. A., Wirtz K. W. A., Wojtczak L., Yaffe M., Zborowski J.   +43 more
core   +3 more sources

Efficiency of the D-chiro-inositol for the polycystic ovary syndrome

Репродуктивная эндокринология, 2019
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that develops in 10–15% of reproductive aged women. Over the past two decades, the inositol effectiveness in normalizing the clinical and hormonal disorders associated with PCOS has been ...
Т. Л. Архипкина, Л. П. Любимова   +1 more
doaj   +1 more source

GTP and Ca2+ Modulate the Inositol 1,4,5-Trisphosphate-Dependent Ca2+ Release in Streptolysin O-Permeabilized Bovine Adrenal Chromaffin Cells [PDF]

, 1991
The inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release was studied using streptolysin O-permeabilized bovine adrenal chromaffin cells. The IP3-induced Ca2+ release was followed by Ca2+ reuptake into intracellular compartments.
Ahnert-Hilger G., Ahnert-Hilger G., B. Stecher, Bhakdi S., Bhakdi S., Brass L. F., Chueh S.-H., Comerford J. G., Danoff S. K., Dawson A. P., Fohr K. J., G. Ahnert-Hilger, Hirata M., Hugo F., J. Scott, Joseph S. K., K. J. Föhr, Kao L.-S., Livett B., M. Gratzl, Rossier M. F., Stoehr S. J., Supattapone S., Worley P. F.   +23 more
core   +1 more source

A metabolomic approach to animal vitreous humor topographical composition: A pilot study [PDF]

, 2014
The purpose of this study was to evaluate the feasibility of a 1H-NMR-based metabolomic approach to explore the metabolomic signature of different topographical areas of vitreous humor (VH) in an animal model.
ATZORI, LUIGI, D'ALOJA, ERNESTO, De Giorgio F, DEMONTIS, ROBERTO, LOCCI, EMANUELA, Nioi M, NOTO, ANTONIO, Rosa MF, SCANO, PAOLA   +8 more
core   +1 more source

Effects of inositol starvation on the levels of inositol phosphates and inositol lipids in Neurospora crassa [PDF]

Biochemical Journal, 1993
An inositol-requiring strain of Neurospora crassa was labelled during growth in liquid medium with [3H]inositol, and the levels of inositol phosphates and phosphoinositides were determined under inositol-sufficient and inositol-starved conditions.
openaire   +3 more sources

A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate–inositol phosphate and inositol phosphate–ADP phosphotransferase activities [PDF]

FEBS Letters, 2008
We describe a multifunctional inositol polyphosphate kinase/phosphotransferase from Solanum tuberosum, StITPKα (GenBank accession number: EF362784), hereafter called StITPK1. StITPK1 displays inositol 3,4,5,6‐tetrakisphosphate 1‐kinase activity: K m = 27 μM, and V max = 19 nmol min−1 mg−1.
Caddick, Samuel E. K., Harrison, Christopher J., Stavridou, Ioanna, Mitchell, Jennifer L., Hemmings, Andrew M., Brearley, Charles A.   +5 more
openaire   +4 more sources