Results 161 to 170 of about 3,938 (203)

The reaction of inositol hexaphosphate with hemoglobin

Biochemical and Biophysical Research Communications, 1970
Abstract The rate of oxygen dissociation from the fully liganded hemoglobin tetramer (Hb4(O2)4) is increased by the presence of inositol hexaphosphate from approximately 50/sec to 180/sec at 22°. It follows from this observation that inositol hexaphosphate is bound by oxygen-saturated human hemoglobin.
Q H, Gibson, R D, Gray
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Activation of Methaemoglobin Peroxidase by Inositol Hexaphosphate

Nature New Biology, 1973
THE effects of organic phosphates such as ATP, 2,3-DPG, and inositol hexaphosphate (IHP) on the properties of reduced haemoglobin have been recognised for several years and have been the subject of intense investigation1–3 Perutz has recently suggested that at least one of these molecules, IHP, may also interact with methaemoglobin4, 5. He concludes on
A G, Mauk, M R, Mauk, F, Taketa
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Structure of inositol hexaphosphate–human deoxyhaemoglobin complex

Nature, 1974
D-2,3-DIPHOSPHOGLYCERATE (DPG) facilitates the transfer of oxygen from human red blood cells to the tissues by lowering the oxygen affinity of haemoglobin1. It does so by combining preferentially with one of the two alternative forms of haemoglobin, namely the deoxy form, in the ratio of 1 mol per mol tetramer.
A, Arnone, M F, Perutz
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Structure of human fluoromethaemoglobin with inositol hexaphosphate

Journal of Molecular Biology, 1977
Abstract Human fluoromethaemoglobin with inositol hexaphosphate (IHP) in 0.05 m -phosphate buffer was crystallized by addition of polyethylene glycol (PEG). The crystals are isomorphous with those of deoxyhaemoglobin A without IHP grown in solutions containing PEG by Ward et al . (1975).
G, Fermi, M F, Perutz
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Inositol hexaphosphate and inositol inhibit DMBA-induced rat mammary cancer

Carcinogenesis, 1995
Because inositol hexaphosphate (InsP6) and inositol (Ins), contained in plants and most mammalian cells, have been demonstrated to have anti-cancer and anti-cell proliferative action in several experimental models of carcinogenesis we have examined the effect of InsP6 +/- Ins on DMBA-induced rat mammary tumor model.
I, Vucenik, G Y, Yang, A M, Shamsuddin
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Inositol Hexaphosphate (IP6) Inhibits Cellular Proliferation In Melanoma

Journal of Surgical Research, 2006
Inositol Hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate found in food sources high in fiber content. We have previously reported IP6 to have significant inhibitory effects against pancreatic cancer in vitro. We hypothesized that the IP6 would significantly inhibit cell growth of cutaneous melanoma in vitro.The melanoma ...
Irfan, Rizvi, Dale R, Riggs, Barbara J, Jackson, Alex, Ng, Cynthia, Cunningham, David W, McFadden   +5 more
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Inositol hexaphosphate inhibits ultraviolet B–induced signal transduction

Molecular Carcinogenesis, 2001
AbstractInositol hexaphosphate (InsP6) has an effective anticancer action in many experimental models in vivo and in vitro. Ultraviolet B (UVB) radiation is believed to be responsible for many of the carcinogenic effects related to sun exposure, and alteration in UVB‐induced signal transduction is associated with UVB‐induced carcinogenesis.
N, Chen, W Y, Ma, Z, Dong
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Inositol Hexaphosphate: III. Content in Soils

Soil Science Society of America Journal, 1958
Abstract Samples of 49 soils were analyzed for inositol‐hexaphosphate phosphorus in the meso form and a supposed isomer of this form. Anion‐exchange chromatography was used to make the separations. The quantities of phosphorus present in the two isomers were correlated (r = 0.73), the phosphorus in the supposed ...
A. G. Caldwell, C. A. Black
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Inositol hexaphosphate: a potential chelating agent for uranium

Radiation Protection Dosimetry, 2007
Chelation therapy is an optimal method to reduce the radionuclide-related risks. In the case of uranium incorporation, the treatment of choice is so far i.v infusion of a 1.4% sodium bicarbonate solution, but the efficacy has been proved to be not very high.
D, Cebrian, A, Tapia, A, Real, M A, Morcillo   +3 more
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IP6 (Inositol Hexaphosphate) as a Signaling Molecule

Current Signal Transduction Therapy, 2012
Inositol hexaphosphate (IP6, InsP6) is a polyphosphorylated carbohydrate with diverse signaling properties. IP6 is plentiful in organisms as diverse as yeast, actinobacteria, mammals and plants. In the plant kingdom, IP6 accumulates during seed development; during germination it is broken down into lower inositol phosphates and micronutrients to ...
Abul Kalam Shamsuddin, Sanchita Bose
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