Results 241 to 250 of about 761,638 (295)

Phosphate, inositol and polyphosphates.

Biochemical Society Transactions, 2016
Eukaryotic cells have ubiquitously utilized the myo-inositol backbone to generate a diverse array of signalling molecules. This is achieved by arranging phosphate groups around the six-carbon inositol ring. There is virtually no biological process that does not take advantage of the uniquely variable architecture of phosphorylated inositol. In inositol
T. Livermore, Cristina Azevedo, B. Kolozsvári, Miranda S. C. Wilson, A. Saiardi   +4 more
semanticscholar   +3 more sources

INOSITOL PHOSPHATE BIOCHEMISTRY

Annual Review of Biochemistry, 1992
PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225 C ONVENTIONAL PHOSPHA TIDYLIN OSITOLS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 226 PHOSPHOLIPASE C . . . . . . . . . .
openaire   +2 more sources

Configuration of Inositol Phosphate in Liver Phosphatidyl Inositol

Nature, 1960
THE hydrolysis of synthetic glycerol 1-(inositol 2-phosphate)1,2 has recently been compared with that of the glycerylphosphoryl inositol isolated from hydrolysates of liver phosphatidyl inositol3. The results suggest that the phosphate group in the original lipid is attached to the 1- or 2-hydroxyl of the myoinositol.
J N, HAWTHORNE, P, KEMP, R B, ELLIS
openaire   +2 more sources

Phosphatidylinositol and inositol phosphate metabolism

Journal of Cell Science, 2001
The six carbons that comprise the inositol ring can be phosphorylated in a combinatorial manner, generating a truly astonishing range of inositol phosphates and inositol lipids. Yet, somehow, the cell can distinguish and utilize several of these metabolites to specifically regulate a variety ...
K, Abel, R A, Anderson, S B, Shears
openaire   +2 more sources

Rapid Analysis of Inositol Phosphates

Journal of Agricultural and Food Chemistry, 2001
Fast and simple analytical methods for the determination of inositol bis- to hexakisphosphates or only inositol hexakisphosphate in foods and feces are presented. The methods are both faster and simpler with regard to analytical detection and sample pretreatment as compared to previously reported methods. The samples are pretreated using extraction and
N G, Carlsson, E L, Bergman, E, Skoglund, K, Hasselblad, A S, Sandberg   +4 more
openaire   +2 more sources

Inositol phosphates and cell signalling

Nature, 1989
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates
M J, Berridge, R F, Irvine
openaire   +2 more sources

Mass measurement of inositol phosphates

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
This review summarises the methods available for the mass measurement of inositol phosphates, i.e., use of radioactive inositol lipid precursors, optical techniques, gas chromatography, mass spectrometry, nuclear magnetic resonance, fast atom bombardment and assays specific for Ins(1,4,5)P3.
Palmer, S, Wakelam, M J
openaire   +3 more sources

Paosphorothioate Analogues of Inositol Phosphates

Phosphorus, Sulfur, and Silicon and the Related Elements, 1990
Abstract Novel analogues of the intracellular second messenger D-myo-inositol 1,4,5-trisphosphate, which possess phosphorothioate groups in place of phosphate groups have been synthesized. They exhibit unusual biological properties which will be of considerable application in understanding the phosphoinositide cycle.
Allan Cooke, Leroy James, Stefan Nahorski, Barry Potter   +3 more
openaire   +1 more source

Inositol, lithium, and the brain.

Psychopharmacology bulletin
This review of the background and present state of knowledge of the interactions of inositol metabolism and lithium commemorates the 150th anniversaries of the discovery of inositol and, independently, of first attempts to use lithium as a therapeutic ...
Agranoff Bw, Fisher Sk
semanticscholar   +1 more source

Inositol Phosphate Metabolism and Signal Transduction

American Review of Respiratory Disease, 1990
Activation of a variety of cell surface receptors results in a biphasic increase in the cytoplasmic Ca2+ concentration, due to the release or mobilization of intracellular Ca2+ stores and to the entry of Ca2+ from the extracellular space. Stimulation of these same receptors also results in the hydrolysis of the minor plasma membrane phospholipid ...
A R, Hughes, D A, Horstman, H, Takemura, J W, Putney   +3 more
openaire   +2 more sources