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From Obscurity to Prominence: IPMK's Expanding Role in Cellular Signaling, Physiology, and Disease. [PDF]
Mishra SH +3 more
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Phosphate, inositol and polyphosphates
Biochemical Society Transactions, 2016Eukaryotic cells have ubiquitously utilized the myo-inositol backbone to generate a diverse array of signalling molecules. This is achieved by arranging phosphate groups around the six-carbon inositol ring. There is virtually no biological process that does not take advantage of the uniquely variable architecture of phosphorylated inositol. In inositol
Thomas M, Livermore +4 more
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INOSITOL PHOSPHATE BIOCHEMISTRY
Annual Review of Biochemistry, 1992PERSPECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225 C ONVENTIONAL PHOSPHA TIDYLIN OSITOLS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 226 PHOSPHOLIPASE C . . . . . . . . . .
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Configuration of Inositol Phosphate in Liver Phosphatidyl Inositol
Nature, 1960THE hydrolysis of synthetic glycerol 1-(inositol 2-phosphate)1,2 has recently been compared with that of the glycerylphosphoryl inositol isolated from hydrolysates of liver phosphatidyl inositol3. The results suggest that the phosphate group in the original lipid is attached to the 1- or 2-hydroxyl of the myoinositol.
J N, HAWTHORNE, P, KEMP, R B, ELLIS
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Phosphatidylinositol and inositol phosphate metabolism
Journal of Cell Science, 2001The six carbons that comprise the inositol ring can be phosphorylated in a combinatorial manner, generating a truly astonishing range of inositol phosphates and inositol lipids. Yet, somehow, the cell can distinguish and utilize several of these metabolites to specifically regulate a variety ...
K, Abel, R A, Anderson, S B, Shears
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Rapid Analysis of Inositol Phosphates
Journal of Agricultural and Food Chemistry, 2001Fast and simple analytical methods for the determination of inositol bis- to hexakisphosphates or only inositol hexakisphosphate in foods and feces are presented. The methods are both faster and simpler with regard to analytical detection and sample pretreatment as compared to previously reported methods. The samples are pretreated using extraction and
N G, Carlsson +4 more
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Inositol phosphates and cell signalling
Nature, 1989Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates
M J, Berridge, R F, Irvine
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Mass measurement of inositol phosphates
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989This review summarises the methods available for the mass measurement of inositol phosphates, i.e., use of radioactive inositol lipid precursors, optical techniques, gas chromatography, mass spectrometry, nuclear magnetic resonance, fast atom bombardment and assays specific for Ins(1,4,5)P3.
Palmer, S, Wakelam, M J
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