Results 101 to 110 of about 306 (128)

A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment. [PDF]

open access: yesMycobiology
Wadhwa K   +9 more
europepmc   +1 more source
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Inotodiol suppresses allergic inflammation in allergic rhinitis mice

International Forum of Allergy & Rhinology, 2023
AbstractBackgroundInotodiol has been proven to have antitumor, antiviral, anti‐inflammatory, and antiallergic properties. This study investigated the immunomodulatory capability of inotodiol in allergic rhinitis (AR) mice.MethodsForty BALB/c mice were divided into four groups, 10 mice each: control (CON), AR with phosphate‐buffered saline (PBS ...
Jaein Chung   +6 more
openaire   +2 more sources

Inotodiol ameliorates the progression of osteoarthritis: An in vitro and in vivo study

Drug Research, 2023
AbstractOsteoarthritis is a common chronic degenerative disease, of which the essence is the degenerative changes of bone and joint cartilage, involving damage in multiple structures such as bone, synovium and joints. In the mechanism of arthritis inflammation is closely related, and therefore
Wanfeng, Qian   +6 more
openaire   +2 more sources

Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation

International Immunopharmacology, 2023
While inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, due to compliance, drug safety, and resistance issues, new medications to replace ICSs are in high demand. Inotodiol, a fungal triterpenoid, showed a unique immunosuppressive property with a preference for mast cells. It exerted a mast cell-stabilizing activity equally potent to
Ye, Liu   +8 more
openaire   +2 more sources

The stereospecific synthesis of inotodiol 3β, 22R-dihydroxylanosta-8,24-diene

Tetrahedron, 1974
Abstract Inotodiol 1a has been stereospecifically synthesised from lanosterol in six steps and Horeau's method utilised to demonstrate the R-configuration at C-22.
J.P. Poyser   +2 more
openaire   +1 more source

Anti-allergic effect of inotodiol, a lanostane triterpenoid from Chaga mushroom, via selective inhibition of mast cell function

International Immunopharmacology, 2020
Inotodiol is a lanostane triterpenoid found only in Chaga mushroom. In the previous study investigating anti-allergic effects of fractionated Chaga mushroom extracts, we have found evidence that purified inotodiol holds an activity to suppress the mast cell function in vivo.
Thi Minh Nguyet, Nguyen   +4 more
openaire   +2 more sources

Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells

Phytomedicine, 2019
Inonotus obliquus, namely as Chaga mushroom, is a medicinal and edible fungus, which is widely used in food and medical fields. Inotodiol, a natural lanostane-type triterpenoid with remarkable pharmacological activities, was isolated from Inonotus obliquus, which its potential anti-tumor molecular mechanism was elaborated poorly.The aim of the present ...
Sun-Dong, Zhang   +9 more
openaire   +2 more sources

Enzymatic synthesis and characterization of novel lipophilic inotodiol–oleic acid conjugates

Food Chemistry
In this study, we establish an efficient enzymatic approach for producing novel inotodiyl-oleates (IOs) from pure inotodiol and oleic acid to improve the properties of inotodiol. For the esterification between inotodiol and oleic acid, CALA and n-hexane were the optimal biocatalyst and solvents for forming IOs with 80.17% conversion yield.
Phu Cuong, Nguyen   +8 more
openaire   +2 more sources

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