Phenotype, Squalene, and Lanosterol Content Variation Patterns During Seed Maturation in Different Leaf-Color Tea Cultivars [PDF]
FoodsSqualene and lanosterol are bioactive compounds with diverse physiological effects, found in relatively high concentrations in tea seed oil. Their levels are significantly influenced by cultivar and fruit maturity.
Jing-Jing Ye +8 more
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A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterolResearch in context [PDF]
EBioMedicineSummary: Background: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors ...
Franz Förster +26 more
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Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages
Cell Reports, 2017 Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in macrophages causes lanosterol, the first sterol intermediate in the cholesterol biosynthetic ...
Jordan S Pober +2 more
exaly +3 more sources
Lanosterol synthase inhibition as a potential approach for re-sensitizing triazole-resistant Aspergillus fumigatus [PDF]
mBioThe increasing prevalence of triazole resistance among Aspergillus fumigatus clinical isolates threatens the efficacy of this front-line treatment, highlighting the urgent need for novel therapeutic targets. In this study, we characterized three putative
Jinhong Xie +12 more
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Post-lanosterol inhibition profile based classification of commonly used prescription medications [PDF]
Translational PsychiatryCholesterol is an essential structural component of all cells, and the sterol biosynthetic pathway provides critical precursors for essential homeostatic molecules. Sterol biosynthesis can be disrupted by pathogenic variants in genes, as well as commonly
Keri A. Tallman +4 more
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Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats [PDF]
Nature CommunicationsCataract caused by crystallin aggregation is the leading cause of vision impairment and blindness globally. The only available treatment option so far is surgery.
Ruiteng Song +6 more
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Journal of Dairy Science, 2023 : Milk contains several components that are important for human nutrition and health. To date, studies on organic and conventional milk have focused on their gross composition and fatty acid content, but little attention has been paid to the differences ...
M. Martini +4 more
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Pharmaceutics, 2022 It has recently been reported that lanosterol (LAN) plays a preventive role against lens opacification through the reversal of crystalline aggregation. However, the effect of LAN is not sufficient to restore lens transparency.
Saori Deguchi +8 more
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Frontiers in Pharmacology, 2022 Purpose: Our previous study observed that human induced pluripotent stem cell (HiPSC)-derived lentoid bodies (LBs) became cloudy with extended culture time, partially mimicking the progress of human age-related cataracts (ARCs) in a dish.
Lifang Zhang +7 more
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Comparative Analyses of Bioactive Compounds in Inonotus obliquus Conks Growing on Alnus and Betula
Biomolecules, 2022 Inonotus obliquus grows in the Northern Hemisphere on some living broadleaved tree species as a pathogen, causing stem rot. In Estonia, the fungus is well known in the Betula species but can also be found on Alnus. Sterile conks of I.
Rein Drenkhan +7 more
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