Biosynthesis of lanosterol in Escherichia coli [PDF]
Synthetic and Systems BiotechnologyLipid composition represents a significant differentiator across the three domains (eukaryotes, bacteria, and archaea) of cellular life. Eukaryotes possess distinct lipids, such as sterols and sphingolipids, generally, these are not commonly found in ...
Wenjie Sun +4 more
doaj +4 more sources
Phenotype, Squalene, and Lanosterol Content Variation Patterns During Seed Maturation in Different Leaf-Color Tea Cultivars [PDF]
FoodsSqualene and lanosterol are bioactive compounds with diverse physiological effects, found in relatively high concentrations in tea seed oil. Their levels are significantly influenced by cultivar and fruit maturity.
Jing-Jing Ye +8 more
doaj +2 more sources
A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterolResearch in context [PDF]
EBioMedicineSummary: Background: Cholesterol is a main contributor to coronary artery disease (CAD). Although the genetic basis of blood cholesterol concentration is well studied, there is currently a lack of studies investigating the genetics of its precursors ...
Franz Förster +26 more
doaj +2 more sources
A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures [PDF]
Steroids, 2004 We describe an inexpensive, low-toxicity and high-yielding method for the production of pure lanosterol and dihydrolanosterol from the commercially available mixture.
Merilyn Manley-Harris, Brian Nicholson
exaly +3 more sources
The Oxidosqualene Cyclase from the Oomycete Saprolegnia Parasitica Synthesizes Lanosterol as a Single Product [PDF]
Frontiers in Microbiology, 2016 The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol or cycloartenol. This is catalyzed by an oxidosqualene cyclase.
Paul Dahlin +5 more
doaj +3 more sources
A Comparative Study of the Effects of Cholesterol and Lanosterol on Hydrated Phosphatidylethanolamine Assemblies: Focusing on Physical Parameters Related to Membrane Fusion [PDF]
MembranesCholesterol (Chol) plays a crucial role in regulating membrane properties and biological processes such as membrane fusion, yet the molecular mechanisms underlying its function remain incompletely understood.
Ayumi Okayama +2 more
doaj +2 more sources
Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages
Cell Reports, 2017 Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in macrophages causes lanosterol, the first sterol intermediate in the cholesterol biosynthetic ...
Elisa Araldi +2 more
exaly +3 more sources
Effect of lanosterol on human cataract nucleus
Indian Journal of Ophthalmology, 2015 Aim: To study the effect of lanosterol on age-related cataractous human lens nuclei. Materials and Methods: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol
P Mahesh Shanmugam +6 more
doaj +3 more sources
Post-lanosterol inhibition profile based classification of commonly used prescription medications [PDF]
Translational PsychiatryCholesterol is an essential structural component of all cells, and the sterol biosynthetic pathway provides critical precursors for essential homeostatic molecules. Sterol biosynthesis can be disrupted by pathogenic variants in genes, as well as commonly
Keri A. Tallman +4 more
doaj +2 more sources
Ocular delivery of lipid nanoparticles-formulated mRNA encoding lanosterol synthase ameliorates cataract in rats [PDF]
Nature CommunicationsCataract caused by crystallin aggregation is the leading cause of vision impairment and blindness globally. The only available treatment option so far is surgery.
Ruiteng Song +6 more
doaj +2 more sources