Results 41 to 50 of about 11,121 (205)
Animal Research and One Health, EarlyView.This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen +2 more
wiley +1 more source
Data in Brief, 2020 The data have been obtained for tautomers and enantiomers of ATTAF-1 and ATTAF-2 that were developed based on antifungal standard drugs with triazole scaffold. These compounds were docked into the human and fungal lanosterol-14α-demethylase.
Hamid Irannejad +3 more
doaj +1 more source
Getting the Big Ones to Pack: Crystal Structure of Vitamin K2 With a Chaperone
Chemistry – A European Journal, EarlyView.A method for obtaining co‐crystals of medium‐size organic molecules and ‐tetrakis(2‐fluoro‐4‐methoxyphenyl)adamantane (TFM) as chaperone was developed. This method yielded a high‐resolution x‐ray crystal structure of menaquinone MK‐4 (vitamin K2), in which layers of chaperone and vitamin guest molecules are found.
Jan Hartenfels +5 more
wiley +1 more source
Ergosterol and Lanosterol from Aspergillus nidulans [PDF]
Microbiology, 1982 Ergosterol was identified as the major free sterol of Aspergillus nidulans by thin-layer chromatography, alumina column chromatography, gas-liquid chromatography, high-performance liquid chromatography, UV spectroscopy, proton magnetic resonance spectroscopy and mass spectral analysis.
B E, Shapiro, M A, Gealt
openaire +2 more sources
Journal of Lipid Research, 1991 Lanosterol 14 alpha-demethylase (P45014DM) is the cytochrome P450 enzyme complex responsible for an early step in cholesterol biosynthesis, namely the 14 alpha-demethylation of lanosterol.
SF Tuck, H Patel, E Safi, CH Robinson
doaj +1 more source
The Journal of Pathology, EarlyView.Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li +6 more
wiley +1 more source
MembranesCholesterol (Chol) plays a crucial role in regulating membrane properties and biological processes such as membrane fusion, yet the molecular mechanisms underlying its function remain incompletely understood.
Ayumi Okayama +2 more
doaj +1 more source
Proceedings, 2017 Lanosterol 14α-demethylase (CYP51) is an essential enzyme in the fungal life cycle and also an important target for antifungal drug development. Selective inhibition of the enzyme would cause depletion of ergosterol and accumulation of lanosterol and ...
Büşra Korkut +3 more
doaj +1 more source
Pest Management Science, EarlyView.Experimental workflow evaluating 14C‐propiconazole absorption and translocation in Coffea arabica with two biodegradable adjuvants, quantified at six post‐application time points using radioscanner and liquid scintillation spectrometry. Abstract BACKGROUND This study evaluated the absorption, translocation and distribution of 14C‐propiconazole applied ...
Valéria de Souza Ivo +4 more
wiley +1 more source
Determinación de presencia de lanosterol sintasa y proteina alfa cristalina A en cristalinos humanos con catarata. [PDF]
, 2019 La catarata es la principal causa de ceguera en países industrializados y en vía de desarrollo, el manejo actual se realiza mediante cirugía de catarata por diferentes técnicas, sin embargo, el acceso limitado a la valoración y tratamiento oportunos ...
Reyes Vivas, Laura Paola
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