Results 51 to 60 of about 11,121 (205)

Solubility of Lanosterol in Organic Solvents and in Water-Alcohol Mixtures at 101.8 kPa

open access: yes, 2020
Lanosterol is a sterol derivative whose physicochemical properties are poorly understood. Pure lanosterol ( \u3e 95%) was isolated from a crude product (54.6%) by a newly developed C18 reverse-phase high-performance liquid chromatography (HPLC) method ...
Forciniti, Daniel, Li, Ke
core   +2 more sources

Lanosterol Solubility in Organic Solvents

open access: yes, 2018
Lanosterol is a sterol derivative that plays a crucial role in the biosynthesis pathway of cholesterol. Recently, it has been found to reverse the formation of cataracts. The physicochemical properties of lanosterol are poorly understood. Pure lanosterol
Forciniti, Daniel, Li, K.
core   +1 more source

Manuka Honey Sinus Irrigation Versus Systemic Itraconazole in Allergic Fungal Rhinosinusitis: Randomised Clinical Trial for Efficacy and Safety

open access: yesClinical Otolaryngology, Volume 51, Issue 6, Page 960-965, November 2026.
ABSTRACT Background Allergic fungal rhinosinusitis (AFRS) is a persistent sinus condition caused by fungal allergies. Endoscopic sinus surgery (ESS) and postoperative systematic and local medical therapies are the most common treatment protocols. Although oral antifungals such as itraconazole are frequently utilised postoperatively, there is increasing
Khalaf Hamead   +4 more
wiley   +1 more source

Effects of oxygenated lanosterol analogs on cholesterol biosynthesis from lanosterol.

open access: yesChemical and Pharmaceutical Bulletin, 1983
The effects of oxygenated lanosterol derivatives (1-14) on cholesterol biosynthesis from [24-3H]-lanosterol were tested in 10000×g supernatant (S10) fraction of rat liver homogenate (RLH). Among the derivatives studied, 7-oxo-24, 25-dihydrolanosterol (11) was most active in depressing cholesterol biosynthesis from lanosterol.
SONODA, YOSHIKO, SATO, YOSHIHIRO
openaire   +3 more sources

اثر چهار هفته تمرین هوازی و مکمل‌دهی سبوس برنج بر تغییرات Lanosterol Synthase در رت‌های تغذیه شده با غذای پُر چرب [PDF]

open access: yesMajallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.
زمینه و هدف: آنزیم Lanosterol Synthase نقش مهمی در فرایند ایجاد بیماری‌های قلبی متابولیک، از جمله دیس لیپیدمی دارد. لذا هدف از انجام این مطالعه بررسی تأثیر چهار هفته تمرین هوازی و مکمل‌دهی سبوس برنج بر تغییرات Lanosterol Synthase در رت‌های تغذیه شده با ...
شکوفه ملکی   +4 more
doaj   +1 more source

Chemical Profiling, Box–Behnken Optimisation, Antimicrobial Activity, and Molecular Docking Study of Z‐Ligustilide Rich Essential Oil From Himalayan Angelica glauca Edgew.

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ABSTRACT Angelica glauca Edgew., a high‐altitude Himalayan medicinal plant, is an important source of bioactive essential oil rich in phthalide derivatives. The present study investigated the influence of environmental conditions and extraction parameters on essential oil yield and chemical composition, with particular emphasis on Z‐ligustilide ...
Balam Singh Bisht   +6 more
wiley   +1 more source

A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes.

open access: yesJournal of Lipid Research, 1980
Highly purified human granulocytes synthesize [14C]farnesol and [14C]squalene but not [14C]sterols from [14C]mevalonic acid. Dimethylsulfoxide was found to be an excellent vehicle for carrying [3H]squalene-2, 3-oxide into the intact cells.
I Shechter, A M Fogelman, G Popják
doaj   +1 more source

Antifungal Activity of Hedychium spicatum Essential Oil Against Candidemia‐Causing Candida tropicalis and Candida parapsilosis: In Vitro Evaluation and Computational Identification of Cis‐γ‐Bisabolene as a Putative CYP51‐Binding Constituent

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Hedychium spicatum essential oil (HSEO) exhibited concentration‐dependent antifungal activity against Candida parapsilosis and Candida tropicalis. GC‐MS identified 29 phytoconstituents, with τ‐cadinol as the major component. Computational analysis identified cis‐γ‐bisabolene as a promising CYP51 inhibitor, showing favorable binding, ADMET properties ...
Preeti Verma   +2 more
wiley   +1 more source

The Oxidosqualene Cyclase from the Oomycete Saprolegnia Parasitica Synthesizes Lanosterol as a Single Product

open access: yesFrontiers in Microbiology, 2016
The first committed step of sterol biosynthesis is the cyclisation of 2,3-oxidosqualene to form either lanosterol or cycloartenol. This is catalyzed by an oxidosqualene cyclase.
Paul Dahlin   +5 more
doaj   +1 more source

NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

open access: yesiScience, 2021
Summary: Lipids, such as cholesterol and fatty acids, influence cell signaling, energy storage, and membrane formation. Cholesterol is biosynthesized through the mevalonate pathway, and aberrant metabolism causes metabolic diseases.
Tsuyoshi Waku   +10 more
doaj   +1 more source

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