Results 71 to 80 of about 11,121 (205)

Yeast Sec14-like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol [PDF]

, 2023
Yeast Sec14-like phosphatidylinositol transfer proteins (PITPs) contain a hydrophobic cavity capable of accepting a single molecule of phosphatidylinositol (PI) or another molecule in a mutually exclusive manner.
Pevala, V, Tahotná, D, Holič, R, Cockcroft, S, Bauer, J, Šťastný, D, Pokorná, L, Griač, P, Petrisková, L, Valachovič, M   +9 more
core   +1 more source

Red to Green: A Lipid Biomarker Record of Tonian‐Ediacaran Algae in Siberia

Geobiology, Volume 24, Issue 5, September/October 2026.
ABSTRACT Multiple lines of evidence point to a major diversification of Eukarya in the late Tonian period, ca. 800–720 Ma ago. Regular steranes, lipid biomarkers primarily sourced from eukaryotes, are first unambiguously reported from multiple sites. Here, we present lipid biomarker stratigraphic records from two drill‐cores from the Lena‐Anabar Basin ...
Adriana I. Rizzo, Andrey Bekker, Anton B. Kuznetsov, Victoria B. Ershova, Yijun Xiong, Karl E. Karlstrom, Simon W. Poulton, Gordon D. Love   +7 more
wiley   +1 more source

A Multifactorial Azole Response in Clinically Relevant Fusarium Species Complexes

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Background Fusarium spp. are clinically relevant filamentous fungi with intrinsically low susceptibility to multiple antifungal agents, particularly azoles, and are included in the World Health Organization fungal priority pathogens list.
Patrícia Helena Grizante Barião, Ludmilla Tonani, Adriana Rodrigues Alves, Otávio Guilherme Gonçalves de Almeida, Cledir Santos, Marcia Regina von Zeska Kress   +5 more
wiley   +1 more source

FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter

Journal of Lipid Research, 2014
The late steps of cholesterol biosynthesis are oxygen demanding, requiring eleven oxygen molecules per synthesized cholesterol molecule. A key enzymatic reaction, which occurs at the top of the Bloch and Kandutsch-Russell pathways, is the demethylation ...
Jun Zhu, Xiangning Jiang, Farid F. Chehab   +2 more
doaj   +1 more source

Clinically Important Emerging and Uncommon Fungal Pathogens in Asia: Epidemiology, Antifungal Resistance and Challenges in Diagnosis and Management

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Fungal infections in Asia are influenced by warm, humid climates, high population density and expanding healthcare systems, which together facilitate the emergence, transmission and detection of both common and rare pathogens. While Candida and Aspergillus species remain the leading causes of invasive fungal disease, increasing attention has ...
Narut Chancharussin, Anupop Jitmuang, Arunaloke Chakrabarti, Methee Chayakulkeeree   +3 more
wiley   +1 more source

Table1_Using genetics to investigate the association between lanosterol and cataract.docx

Background: Cataract is one of the most prevalent causes of blindness worldwide. Whilst surgery is the primary treatment for cataracts, it is not always an available option, particularly in developing countries.
Loukas Zagkos (14309460), Fotios Drenos (113686), Alexander C. Day (7406411), Munisa Hashimi (17987173), Hasnat A. Amin (12287956)   +4 more
core   +1 more source

Protein Engineering of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase into Parkeol Synthase

, 2016
A Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase mutant, ERG7T384Y/Q450H/V454I, produced parkeol but not lanosterol as the sole end product. Parkeol undergoes downstream metabolism to generate compounds 9 and 10. In vitro incubation of parkeol
Tain-Chang Hu (2032885), Cheng-Hsiang Chang (2032888), Tung-Kung Wu (380797), Wen-Shiang Shie (2032894), Yuan-Ting Liu (2032891)   +4 more
core   +1 more source

Structural Analogues of Lanosterol from Marine Organisms of the Class as Potential Inhibitors of Human and Lanosterol 14α-demethylases

Natural Product Communications, 2017
Lanosterol 14α-demethylases (hemoproteins of the cytochrome P450(51) family) are involved in biosynthesis of different membrane sterols, including animal cholesterol, fungal ergosterol and C24-modified plant and protozoa sterols.
Leonid A. Kaluzhskiy, Tatsiana V. Shkel, Natalia V. Ivanchina, Alla A. Kicha, Irina P. Grabovec, Andrei A. Gilep, Natallia V. Strushkevich, Mikhail A. Chernovetsky, Alexei E. Medvedev, Sergey A. Usanov, Alexis S. Ivanov   +10 more
doaj   +1 more source

Molecular Dynamics Simulation of the Structure of Dimyristoylphosphatidylcholine Bilayers with Cholesterol, Ergosterol, and Lanosterol [PDF]

, 2001
Five molecular dynamics computer simulations were performed on different phospholipid:sterol membrane systems in order to study the influence of sterol structure on membrane properties.
Smondyrev, Alexander M., Berkowitz, Max L.   +1 more
core   +1 more source

ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis

Journal of Lipid Research, 2016
Mammalian cells synthesize various sterol molecules, including the C30 sterol, lanosterol, as cholesterol precursors in the endoplasmic reticulum. The build-up of precursor sterols, including lanosterol, displays cellular toxicity.
Yoshio Yamauchi, Shinji Yokoyama, Ta-Yuan Chang   +2 more
doaj   +1 more source