Results 81 to 90 of about 17,625 (221)

In silico prediction of ATTAF-1 and ATTAF-2 selectivity towards human/fungal lanosterol 14α-demethylase using molecular dynamic simulation and docking approaches

Informatics in Medicine Unlocked, 2020
The emergence of resistance to azole drugs, presented significant problems for medicine that could be overcome by advances in antifungal design. We convinced that the crystal structures of fungal and host lanosterol-14α-demethylases in complex with a ...
Hamid Irannejad, Saeed Emami, Hassan Mirzaei, Seyedeh Mahdieh Hashemi   +3 more
doaj   +1 more source

Pseudolaric Acid B Combats Drug‐Resistant Candida albicans Infection via Dual‐Action Mechanisms of Direct Antifungals and Vaginal Microbiota Restoration

Microbial Biotechnology, Volume 19, Issue 3, March 2026.
We propose a novel therapeutic approach against fungal infection: Pseudolaric acid B directly eradicates C. albicans via Erg11 inhibition and uniquely, restores vaginal microecological homeostasis by promoting probiotic lactobacilli, addressing both the pathogen and the dysbiotic environment.
Tianmeng Shao, Yunshan Zhang, Binqing Xue, Weihua Chu   +3 more
wiley   +1 more source

Synthetic Biology and Metabolic Engineering of Microalgae for Sustainable Lipid and Terpenoid Production: An Updated Perspective

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1359-1376, March 2026.
ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka, Yu Wang, Sally Do, Julia Yuson, Samir Kumar Khanal, Krzysztof Zienkiewicz, Zhi‐Yan Du   +6 more
wiley   +1 more source

Cholesterol and nicotinic acetylcholine receptor: An intimate nanometer-scale spatial relationship spanning the billion year time-scale [PDF]

, 2016
Once the sterol biosynthetic machinery had progressed over the course of several million years to yield cholesterol, this neutral lipid became an omnipresent and essential component of biomembranes in Eukaryotes.
Barrantes, Francisco Jose
core   +1 more source

Glycoalkaloid‐Free Starch Potatoes Generated by CRISPR/Cas9‐Mediated Mutations of Genes in the Glycoalkaloid Biosynthesis Pathway Enable More Sustainable Uses of By‐Products From Starch Production

Plant Biotechnology Journal, Volume 24, Issue 3, Page 1344-1358, March 2026.
ABSTRACT Steroidal glycoalkaloids (SGAs) are toxic cholesterol‐derived secondary metabolites present in several Solanaceae species. In potato, tuber SGA levels are for reasons of toxicity of concern in both table and starch cultivars. In the latter, SGAs bind to proteins and fibres in starch production side‐streams and prevent their further uses as ...
Ying Liu, Irene Merino, Mareike Gutensohn, Annika I. Johansson, Kalle Johansson, Mariette Andersson, Per Hofvander, Folke Sitbon   +7 more
wiley   +1 more source

Genetic engineering and molecular characterization of yeast strain expressing hybrid human-yeast squalene synthase as a tool for anti-cholesterol drug assessment [PDF]

, 2016
AIMS: The main objective of the study is molecular and biological characterization of the human-yeast hybrid squalene synthase (SQS), as a promising target for treatment of hypercholesterolaemia.
Burzynska, Beata, Danikiewicz, Witold, Gora, Monika, Kapur, S., Komaszylo, Joanna, Leszczynska, Agata, Maciejak, Agata, Plochocka, Danuta, Sojka, M., Swiezewska, Ewa, Tułacz, Dorota, Warchol, I., Wysocka-Kapcinska, Monika   +12 more
core   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter

Journal of Lipid Research, 2014
The late steps of cholesterol biosynthesis are oxygen demanding, requiring eleven oxygen molecules per synthesized cholesterol molecule. A key enzymatic reaction, which occurs at the top of the Bloch and Kandutsch-Russell pathways, is the demethylation ...
Jun Zhu, Xiangning Jiang, Farid F. Chehab   +2 more
doaj   +1 more source

Moroccan propolis: a natural antioxidant, antibacterial, and antibiofilm against Staphylococcus aureus with no induction of resistance after continuous exposure [PDF]

, 2018
This study was performed to evaluate the total phenols, flavonoids, and antioxidant activities of twenty-four propolis samples from different regions of Morocco.
AAZZA, Smail, Bankova, Vassya, EL-GEUNDOUZ, Soukaina, Faleiro, Maria Leonor, Lyoussi, Badiaa, Miguel, Maria, Neto, Luís, Popova, Milena   +7 more
core   +1 more source

Therapeutic Activities and Phytochemical Composition of Helianthus annuus L. Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The sunflower (Helianthus annuus L.) is a plant commonly used in agriculture and the fuel industry, as well as being an ornamental garden plant. However, its biologically active compounds make it an interesting plant for medicinal purposes. This review evaluated the phytochemistry of sunflower leaves, stems, receptacles, flowers, seeds, and ...
Marina dos Santos Barreto, Wesley Lisboa de Jesus, Maria Eduarda de Britto Sá, Jessiane Bispo de Souza, Ronaldy Santana Santos, Júlia Santana Lisboa, Pedro Henrique Macedo Moura, Deise Maria Rego Rodrigues Silva, Eloia Emanuelly Dias Silva, Lysandro Pinto Borges, Adriana Gibara Guimarães   +10 more
wiley   +1 more source