Results 81 to 90 of about 11,121 (205)

Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice.

PLoS Genetics, 2020
Skin lesions, cataracts, and congenital anomalies have been frequently associated with inherited deficiencies in enzymes that synthesize cholesterol. Lanosterol synthase (LSS) converts (S)-2,3-epoxysqualene to lanosterol in the cholesterol biosynthesis ...
Yoichi Wada, Atsuo Kikuchi, Akimune Kaga, Naoki Shimizu, Junya Ito, Ryo Onuma, Fumiyoshi Fujishima, Eriko Totsune, Ryo Sato, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Kota Sato, Toru Nakazawa, Keiko Nakayama, Yoko Aoki, Setsuya Aiba, Kiyotaka Nakagawa, Shigeo Kure   +18 more
doaj   +1 more source

Table2_Using genetics to investigate the association between lanosterol and cataract.docx

Background: Cataract is one of the most prevalent causes of blindness worldwide. Whilst surgery is the primary treatment for cataracts, it is not always an available option, particularly in developing countries.
Loukas Zagkos (14309460), Fotios Drenos (113686), Alexander C. Day (7406411), Munisa Hashimi (17987173), Hasnat A. Amin (12287956)   +4 more
core   +1 more source

Strategische Oxidationsreaktionen an Lanosterol zur Synthese umgelagerter Spiro-Lanostane [PDF]

In this work targeted oxidations of Lanosterol, specifically at the sidechain, were investigated and optimized.
Heinzig, Nicolas
core   +1 more source

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Journal of Lipid Research, 2005
Diabetic dyslipidemia requires simultaneous treatment with hypoglycemic agents and lipid-modulating drugs. We recently described glycogen phosphorylase inhibitors that reduce glycogenolysis in cells and lower plasma glucose in ob/ob mice (J. Med.
H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway   +10 more
doaj   +1 more source

Inhibitory Effect of the Plant against Biological Activities of Snake Venom

Natural Product Communications, 2014
The ability of extracts of the plant Clusia fluminensis Planch & Triana (Clusiaceae Lindl.) to neutralize proteolysis, clotting, hemolysis, hemorrhagic and lethality activities of Bothrops jararaca snake venom was studied.
Eduardo Coriolano de Oliveira, Maria Carolina Anholeti, Thaisa Francielle Domingos, Camila Nunes Faioli, Eladio Flores Sanchez, Selma Ribeiro de Paiva, André Lopes Fuly   +6 more
doaj   +1 more source

Synthesis, Evaluation, and Structure–Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation

, 2018
We describe here the development of potent synthetic analogues of the naturally occurring triterpenoid lanosterol to reverse protein aggregation in cataracts.
Zimo Yang (117047), Liguo Wang (105768), Xiang-Jun Chen (5782880), Yue Wu (1262184), Yong-Bin Yan (295926), Xinglin Yang (1958083), Yi-Bo Xi (295924), Yu Rao (85442)   +7 more
core   +2 more sources

Atomic basis for functional evolution of plant lanosterol synthase

Lanosterol synthase (LAS) and cycloartenol synthase (CAS) use 2,3-oxidosqualene as their substrate to produce lanosterol and cycloartenol for biosynthesis of essential sterols in animals and fungi (lanosterol) and plants (cycloartenol), respectively ...
Feng, Laibao, Qi, Xiaoquan, Wu, Ruibo, Xia, Tong, Diao, Hongjuan, Stephenson, Michael, Osbourn, Anne, Ma, Aimin, Sun, Juncong   +8 more
core   +1 more source

Synthesis of lanosterol analogs with lengthened side chains and their effects on cholesterol biosynthesis from lanosterol.

Chemical and Pharmaceutical Bulletin, 1984
Starting from 3β-acetoxy-25, 26, 27-trinorlanost-8-en-24-al (1), eight lanosterol analogs (10-17) with longer side chains side chains than that of lanosterol were synthesized by Wittig reaction followed by catalytic hydrogenation. Cholesterol biosynthesis was examined in rat hepatic subcellular preparation (S10) incubated with [24-3H]-lanosterol in the
SATO, YOSHIHIRO, SONODA, YOSHIKO
openaire   +3 more sources

Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates.

Journal of Lipid Research, 1986
With [3H-24,25]-dihydrolanosterol as substrate, large-scale metabolic formation of intermediates of lanosterol demethylation was carried out to identify all compounds in the metabolic process.
A Shafiee, J M Trzaskos, Y K Paik, J L Gaylor   +3 more
doaj   +1 more source

Lanosterol and Cholesterol-Induced Variations in Bilayer Elasticity Probed by ²H NMR Relaxation

, 2016
The influences of lanosterol on lipid bilayers have been compared to those of cholesterol by combining deuterium (2H) NMR spin relaxation studies with segmental order parameter measurements.
Gary V. Martinez (497899), Emily M. Dykstra (2724829), Silvia Lope-Piedrafita (453863), Michael F. Brown (477787)   +3 more
core   +1 more source