Results 91 to 100 of about 17,625 (221)

Lateral-Pressure Profiles in Cholesterol-DPPC Bilayers

, 2005
By means of atomistic molecular dynamics simulations, we study cholesterol-DPPC (dipalmitoyl phosphatidylcholine) bilayers of different composition, from pure DPPC bilayers to a 1:1 mixture of DPPC and cholesterol.
Patra, Michael
core   +1 more source

Structural Analogues of Lanosterol from Marine Organisms of the Class as Potential Inhibitors of Human and Lanosterol 14α-demethylases

Natural Product Communications, 2017
Lanosterol 14α-demethylases (hemoproteins of the cytochrome P450(51) family) are involved in biosynthesis of different membrane sterols, including animal cholesterol, fungal ergosterol and C24-modified plant and protozoa sterols.
Leonid A. Kaluzhskiy, Tatsiana V. Shkel, Natalia V. Ivanchina, Alla A. Kicha, Irina P. Grabovec, Andrei A. Gilep, Natallia V. Strushkevich, Mikhail A. Chernovetsky, Alexei E. Medvedev, Sergey A. Usanov, Alexis S. Ivanov   +10 more
doaj   +1 more source

Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice.

PLoS Genetics, 2020
Skin lesions, cataracts, and congenital anomalies have been frequently associated with inherited deficiencies in enzymes that synthesize cholesterol. Lanosterol synthase (LSS) converts (S)-2,3-epoxysqualene to lanosterol in the cholesterol biosynthesis ...
Yoichi Wada, Atsuo Kikuchi, Akimune Kaga, Naoki Shimizu, Junya Ito, Ryo Onuma, Fumiyoshi Fujishima, Eriko Totsune, Ryo Sato, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Kota Sato, Toru Nakazawa, Keiko Nakayama, Yoko Aoki, Setsuya Aiba, Kiyotaka Nakagawa, Shigeo Kure   +18 more
doaj   +1 more source

ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis

Journal of Lipid Research, 2016
Mammalian cells synthesize various sterol molecules, including the C30 sterol, lanosterol, as cholesterol precursors in the endoplasmic reticulum. The build-up of precursor sterols, including lanosterol, displays cellular toxicity.
Yoshio Yamauchi, Shinji Yokoyama, Ta-Yuan Chang   +2 more
doaj   +1 more source

Nanoscale Membrane Domain Formation Driven by Cholesterol [PDF]

, 2017
Biological membranes generate specific functions through compartmentalized regions such as cholesterol-enriched membrane nanodomains that host selected proteins.
Javanainen, Matti, Martinez-Seara, Hector, Vattulainen, Ilpo   +2 more
core   +2 more sources

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Journal of Lipid Research, 2005
Diabetic dyslipidemia requires simultaneous treatment with hypoglycemic agents and lipid-modulating drugs. We recently described glycogen phosphorylase inhibitors that reduce glycogenolysis in cells and lower plasma glucose in ob/ob mice (J. Med.
H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway   +10 more
doaj   +1 more source

UTILISING Zn AND Cu PRODU T IN THE CORN MEAL SUBSTRATE AT Saccharomyces cerev s ae BIOPRO ESS AND ITS IMPLEMENTATION ON INTERNAL QUALITY OF BROILER [PDF]

, 2009
This research was conducte to find out the effect and optimal percentage of adding Zn and Cu proteinat supplement product of fermentation by Saccharomyces cerev s ae in the ration on internal quality of the broiler.The experiment use 125 broiler day ol
Abun, Abun, Darana, S, Destian, A, Widjastuti, T   +3 more
core  

In vitro and in vivo antifungal profile of a novel and long acting inhaled azole, PC945, on Aspergillus fumigatus infection [PDF]

, 2017
The profile of PC945, a novel triazole antifungal, designed for administration via inhalation, hasbeen assessed in a range of in vitro and in vivo studies.
Alexandre Alanio, Andrew G. S. Warrilow, Arendrup, Blaser, Brown, Bueid, CDC, Clinical and Laboratory Standards Institute, Clinical and Laboratory Standards Institute, Copeland, Damien Crepin, Denning, Denning, Denning, Denning, Diane E. Kelly, Diaz-Guerra, Drew, Drusano, Franz Lagasse, Garth Rapeport, Genki Kimura, Gifford, Gurpreet Sehra, Herbst, Hilberg, Hoeben, Howard, Jefcoate, Jefcoate, Jeong, John King-Underwood, John Murray, Jonathan Shannon, Josie E. Parker, Kazuhiro Ito, Kelly, Lat, Lauren Anderson-Dring, Levin, Lutz, Matthew Crittall, Michael Cooke, Mihiro Sunose, Park, Parker, Pete Strong, Rocchi, Roden, Rodrigues, Sharma, Southam, Steven L. Kelly, Stuart Onions, Stéphane Bretagne, Takahiro Nakaoki, Thomas Colley, Walsh, Warrilow, Warrilow, Wexler, Wickham, Wong, Yasuo Kizawa, Zaas   +64 more
core   +3 more sources

Inhibitory Effect of the Plant against Biological Activities of Snake Venom

Natural Product Communications, 2014
The ability of extracts of the plant Clusia fluminensis Planch & Triana (Clusiaceae Lindl.) to neutralize proteolysis, clotting, hemolysis, hemorrhagic and lethality activities of Bothrops jararaca snake venom was studied.
Eduardo Coriolano de Oliveira, Maria Carolina Anholeti, Thaisa Francielle Domingos, Camila Nunes Faioli, Eladio Flores Sanchez, Selma Ribeiro de Paiva, André Lopes Fuly   +6 more
doaj   +1 more source

Microbial community dynamics during composting of sewage sludge and straw studied through phospholipid and neutral lipid analysis [PDF]

, 2008
The composting process involves a succession of different communities of microorganisms that decompose the initial material, transforming it into a stable final product. In thiswork, the levels of phospholipid fatty acid (PLFA), neutral lipid fatty acid (
Amir, Soumia, Hafidi, Mohamed, Merlina, Georges, Pinelli, Eric, Revel, Jean-Claude, Winterton, Peter   +5 more
core   +3 more sources