Results 91 to 100 of about 11,121 (205)

The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study

Atherosclerosis Plus
Background and aims: Hydroxychloroquine (HCQ) has a variable effect on cholesterol synthesis. To clarify this, we assessed the effect of HCQ on the cholesterol-synthesis pathway in individuals with low and high cholesterol absorption efficiency.
Piia Simonen, Lotta Ulander, Kari K. Eklund, Mikko Niemi, Janne T. Backman, Helena Gylling, Juha Sinisalo   +6 more
doaj   +1 more source

Enzyme Redesign:  Two Mutations Cooperate to Convert Cycloartenol Synthase into an Accurate Lanosterol Synthase

, 2016
Efforts to modify the catalytic specificity of enzymes consistently show that it is easier to broaden the substrate or product specificity of an accurate enzyme than to restrict the selectivity of one that is promiscuous. Described herein are experiments
Silvia Lodeiro (2385778), Tanja Schulz-Gasch (1822795), Seiichi P. T. Matsuda (1363896)   +2 more
core   +1 more source

Chemical and microbial transformations of some lanosterol derivatives

, 1969
Restricted Item. Print thesis available in the University of Auckland Library or may be available through Interlibrary Loan.Attempts have been made to transform lanosterol, by both chemical and microbial means, into compounds of potential pharmacological
Bartley, John Peter
core  

A ²H-NMR study of the comparative effects of lanosterol and cholesterol on model membranes

, 1985
Suspensions of sn-2 deuterated ²H-DPPC-d31 containing various concentrations of either lanosterol or cholesterol were compared using deuterium nuclear magnetic resonance spectroscopy (²H-NMR) and differential scanning calorimetry (DSC). The alpha face of
Wallace, Julia C.
core   +1 more source

Efficient cyclization of squalene epoxide to lanosterol with immobilized cells of baker's yeast

, 2002
The cyclization of squalene epoxide to lanosterol with baker's yeast (Saccharomyces cerevisiae) can conveniently be carried out in aqueous solution with glass cored immobilisates of cells in calcium alginate.
Rotthaus, Olaf, Demuth, Martin
core   +1 more source

Construction of a model of the Candida albicans lanosterol 14-alpha-demethylase active site using homology modelling technique

, 1998
On the basis of all hitherto known P450 X-ray structures and applying standard homology modelling procedures a three-dimensional model of the lanosterol-14α-demethylase active site was constructed.
Hans-Dieter Höltje, Caterina Fattorusso, FATTORUSSO, CATERINA, HOELTJE H. D.   +3 more
core   +1 more source

CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles

Nature Communications
Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity of cytochrome P450 (CYP) 51 enzymes which are responsible for removing the C14α-methyl group ...
Yiru Jin, Somrita Basu, Mei Feng, Yu Ning, Indeewara Munasinghe, Arline M. Joachim, Junan Li, Lingli Qin, Robert Madden, Hannah Burks, Philip Gao, Judy Qiju Wu, Salma Waheed Sheikh, April C. Joice, Chamani Perera, Karl A. Werbovetz, Kai Zhang, Michael Zhuo Wang   +17 more
doaj   +1 more source

SYNTHESIS OF LANOSTEROL IN VIVO

Journal of Biological Chemistry, 1957
K, BLOCH, R B, CLAYTON, P B, SCHNEIDER
openaire   +2 more sources

Development of a QAMS Analysis Method for Industrial Lanolin Alcohol Based on the Concept of Analytical Quality by Design

Separations
The Analytical Quality by Design (AQbD) concept was adopted to establish a quantitative analysis of multi-components with a single marker (QAMS) method for industrial lanolin alcohol, targeting cholesterol, lanosterol, and 24,25-dihydrolanosterol.
Kaidierya Abudureheman, Qinglin Wang, Hao Zhang, Xingchu Gong   +3 more
doaj   +1 more source

Lanosterol Disrupts Aggregation of Human γD-Crystallin by Binding to the Hydrophobic Dimerization Interface

, 2018
Cataracts are a leading cause of vision impairment, which stem from the misfolding and aggregation of crystallins in the eye lens. Despite its prevalence and severity, the detailed mechanism by which misfolded crystallins aggregate into cataracts remains
Hongsuk Kang (1512754), Zaixing Yang (172382), Ruhong Zhou (277621)   +2 more
core   +1 more source