Results 101 to 110 of about 17,625 (221)

Effect of voriconazole on Candida tropicalis biofilms: Relation with ERG genes expression [PDF]

, 2016
Candida tropicalis has emerged as the third most prevalent fungal pathogens and its ability to form biofilms has been considered one of the most important virulence factors, since biofilms represent high tolerance to antifungal agents.
C Luca De, CA Kumamoto, DW Williams, DW Williams, E Fonseca, EM Kojic, FC Bizerra, GS Baillie, KJ Livak, LJ Douglas, M Negri, M Negri, MA Al-Fattani, Mariana Henriques, NN Mishra, P Eggimann, P Muñoz, P Vandeputte, PK Mukherjee, RJ Kothavade, S Silva, S Silva, S Silva, S Silva, S Silva, SK Fridkin, SP Hawser, Sónia Silva, T Fernandes, Tânia Fernandes   +29 more
core   +1 more source

The role of Coenzyme Q10 in statin-associated myopathy [PDF]

, 2009
Statins, or 3-hydroxyl-3-methylglutaryl coenzyme HMG-CoA reductase inhibitors,\ud are cholesterol-lowering drugs which are frequently used in the primary and secondary\ud prevention of coronary artery disease. Current research and recommendations support\
Kalra, Dr Sanjay
core  

Synthesis of lanosterol analogs with lengthened side chains and their effects on cholesterol biosynthesis from lanosterol.

Chemical and Pharmaceutical Bulletin, 1984
Starting from 3β-acetoxy-25, 26, 27-trinorlanost-8-en-24-al (1), eight lanosterol analogs (10-17) with longer side chains side chains than that of lanosterol were synthesized by Wittig reaction followed by catalytic hydrogenation. Cholesterol biosynthesis was examined in rat hepatic subcellular preparation (S10) incubated with [24-3H]-lanosterol in the
Y, Sato, Y, Sonoda
openaire   +3 more sources

Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates.

Journal of Lipid Research, 1986
With [3H-24,25]-dihydrolanosterol as substrate, large-scale metabolic formation of intermediates of lanosterol demethylation was carried out to identify all compounds in the metabolic process.
A Shafiee, J M Trzaskos, Y K Paik, J L Gaylor   +3 more
doaj   +1 more source

The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study

Atherosclerosis Plus
Background and aims: Hydroxychloroquine (HCQ) has a variable effect on cholesterol synthesis. To clarify this, we assessed the effect of HCQ on the cholesterol-synthesis pathway in individuals with low and high cholesterol absorption efficiency.
Piia Simonen, Lotta Ulander, Kari K. Eklund, Mikko Niemi, Janne T. Backman, Helena Gylling, Juha Sinisalo   +6 more
doaj   +1 more source

Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. [PDF]

, 2017
Epoxides are highly useful synthons and biosynthons for the construction of complex natural products during total synthesis and biosynthesis, respectively.
Garcia-Borràs, Marc, Hirayama, Yuichiro, Houk, KN, Li, Dehai H, Li, Li, Tang, Mancheng C, Tang, Yi, Watanabe, Kenji, Zou, Yi   +8 more
core  

Estudio de la fracción insaponificable obtenida del aceite extraído de la semilla de la luffa cylindrica [PDF]

, 2008
Se obtuvo y caracterizo la materia insaponificable del aceite de las semillas de la Luffa Cylindrica procedentes de Risaralda suministrada por la empresa ESTROCOL. La materia prima se sometio a un proceso de secado para la posterior extraccion del aceite
Arcila González, Luis F., Fernández Tenorio, Juliana   +1 more
core  

CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles

Nature Communications
Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity of cytochrome P450 (CYP) 51 enzymes which are responsible for removing the C14α-methyl group ...
Yiru Jin, Somrita Basu, Mei Feng, Yu Ning, Indeewara Munasinghe, Arline M. Joachim, Junan Li, Lingli Qin, Robert Madden, Hannah Burks, Philip Gao, Judy Qiju Wu, Salma Waheed Sheikh, April C. Joice, Chamani Perera, Karl A. Werbovetz, Kai Zhang, Michael Zhuo Wang   +17 more
doaj   +1 more source

Development of a QAMS Analysis Method for Industrial Lanolin Alcohol Based on the Concept of Analytical Quality by Design

Separations
The Analytical Quality by Design (AQbD) concept was adopted to establish a quantitative analysis of multi-components with a single marker (QAMS) method for industrial lanolin alcohol, targeting cholesterol, lanosterol, and 24,25-dihydrolanosterol.
Kaidierya Abudureheman, Qinglin Wang, Hao Zhang, Xingchu Gong   +3 more
doaj   +1 more source

SYNTHESIS OF LANOSTEROL IN VIVO

Journal of Biological Chemistry, 1957
K, BLOCH, R B, CLAYTON, P B, SCHNEIDER
openaire   +2 more sources