Results 31 to 40 of about 11,121 (205)

Lanosterol biosynthesis pathway in GtoPdb v.2023.1 [PDF]

, 2023
Lanosterol is a precursor for cholesterol, which is synthesized primarily in the liver in a pathway often described as the mevalonate or HMG-CoA reductase pathway.
Benson, Helen E., Helen E. Benson
core   +1 more source

Increased lanosterol turnover : a metabolic burden for daunorubicin-resistant leukemia cells [PDF]

, 2015
The cholesterol metabolism is essential for cancer cell proliferation. We found the expression of genes involved in the cholesterol biosynthesis pathway up-regulated in the daunorubicin-resistant leukemia cell line CEM/R2, which is a daughter cell line ...
Witek, B, Witek, Barbara, Hasanuzzaman Bhuiyan, Bhuiyan, Hasanuzzaman,, Broom, O, Oliver Broom, Lindahl, Anna,, Stäubert, Claudia,, Anna Lindahl, Nordström, Anders,, Nordström, Anders, Broom, Oliver, Lindahl, Anna, Stäubert, Claudia, Witek, Barbara,, Krakowsky, R, Krakowsky, Rosanna, Staubert, C, Rosanna Krakowsky, Lindahl, A,, Bhuiyan, H, Bhuiyan, Hasanuzzaman, Claudia Stäubert, Anders Nordström, Barbara Witek, Nordstrom, A, Krakowsky, Rosanna,, Broom, Oliver,   +27 more
core   +2 more sources

Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly disease have significant limitations.
Mei Feng, Yiru Jin, Sihyung Yang, Arline M. Joachim, Yu Ning, Luis M. Mori-Quiroz, Jacob Fromm, Chamani Perera, Kai Zhang, Karl A. Werbovetz, Michael Zhuo Wang   +10 more
doaj   +1 more source

Effects of lanosterol on in vitro maturation of porcine oocytes [PDF]

, 2010
[EN] FF-MAS and T-MAS sterols, intermediaries in the cholesterol biosynthetic pathway present in all cells, may represent the physiological signal that instructs the crocyte to reinitiate meiosis.
Marco-Jiménez, Francisco, Llobat, L, Vicente Antón, José Salvador   +2 more
core   +1 more source

Digitonide precipitable sterols: A reevaluation with special attention to lanosterol

, 1982
The ability of digitonin to precipitate lanosterol from prepared mixtures and biological sources was evaluated. Commercially available lanosterol was determined to be composed of about 60% lanosterol and 40% dihydrolanosterol.
Cenedella, Richard J., Richard J. Cenedella   +1 more
core   +1 more source

Sterol Metabolism and Transport in Atherosclerosis and Cancer

Frontiers in Endocrinology, 2018
Cholesterol is a vital lipid molecule for mammalian cells, regulating fluidity of biological membranes, and serving as an essential constituent of lipid rafts. Mammalian cells acquire cholesterol from extracellular lipoproteins and from de novo synthesis.
Yoshio Yamauchi, Yoshio Yamauchi, Maximillian A. Rogers   +2 more
doaj   +1 more source

Triterpenoids from The Bark of Garcinia porecta and their Cytotoxic Activity against MCF7 Breast Cancer Lines

Alchemy, 2019
The Garcinia genus is a well known tropical plant in the Indo-Malesiana region and mainly distributed in tropical countries including Indonesia, Thailand, and Malaysia. Previous phytochemical studies on Garcinia species have led to the identification and
Darwati Darwati, Alya Tsamrotul, Tati Herlina, Tri Mayanti, Nurlelasari Nurlelasari, Kansy Haikal, Unang Supratman   +6 more
doaj   +1 more source

Screening of Inhibitory Effects Lanosterol on Butyrylcholinesterase, Acetylcholinesterase and Carbonic Anhydrase Enzymes

, 2023
In this study, for the first time, the antiglaucoma and anticholinergic properties from lanosterol were appraised and researched using different bioanalytical methods and compared with standards.
Üç, Eda Mehtap
core   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

Mevalonate metabolism by renal tissue in vitro

Journal of Lipid Research, 1974
Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid.
Philip Raskin, Marvin D. Siperstein
doaj   +1 more source