Results 21 to 30 of about 11,121 (205)

Isolation and identification of new constituents in milk fat

Journal of Lipid Research, 1970
After removal of cholesterol on a digitonin column, the unsaponifiable matter of milk fat was examined for alcoholic substituents. Derivatization with pyruvic acid chloride 2,6-dinitrophenylhydrazone and fractionation of the derivatives gave four main ...
C.R. Brewington, E.A. Caress, D.P. Schwartz   +2 more
doaj   +1 more source

Lanosterol Synthase in Dicotyledonous Plants [PDF]

Plant and Cell Physiology, 2006
Sterols are important as structural components of plasma membranes and precursors of steroidal hormones in both animals and plants. Plant sterols show a wide structural variety and significant structural differences from those of animals. To elucidate the origin of structural diversity in plant sterols, their biosynthesis has been extensively studied ...
Masashi, Suzuki, Ting, Xiang, Kiyoshi, Ohyama, Hikaru, Seki, Kazuki, Saito, Toshiya, Muranaka, Hiroaki, Hayashi, Yuji, Katsube, Tetsuo, Kushiro, Masaaki, Shibuya, Yutaka, Ebizuka   +10 more
openaire   +2 more sources

Biosynthesis of squalene and sterols by rat aorta

Journal of Lipid Research, 1971
The synthesis of nonsaponifiable compounds from radioactive mevalonate by segments of adult rat aorta was studied in vitro. The labeled products consisted largely of substances with the chromatographic and chemical behavior of squalene, lanosterol ...
MARIE M. DALY
doaj   +1 more source

Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis

Journal of Lipid Research, 1966
Homogenates of epidermis from rat skin were centrifuged at 10,000 · g for 20 min. The supernatant fraction (“whole homogenate”) catalyzed the demethylation of lanosterol (C30) to yield C27-sterols. The rate of reaction was measured by the rate of release
J.L. Gaylor, C.V. Delwiche, D.R. Brady, A.J. Green   +3 more
doaj   +1 more source

Ophthalmic In Situ Gelling System Containing Lanosterol Nanoparticles Delays Collapse of Lens Structure in Shumiya Cataract Rats

Pharmaceutics, 2020
We attempted to prepare ophthalmic in situ gel formulations containing lanosterol (Lan) nanoparticles (LA-NPs/ISG) and investigated the characteristics, delivery pathway into the lens, and anti-cataract effects of LA-NPs/ISG using SCR-N (rats with slight
Noriaki Nagai, Kazuki Umachi, Hiroko Otake, Mikako Oka, Noriko Hiramatsu, Hiroshi Sasaki, Naoki Yamamoto   +6 more
doaj   +1 more source

Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake

Journal of Lipid Research, 2010
The Forkhead transcription factors FoxO1, FoxO3a, and FoxO4 play a prominent role in regulating cell survival and cell cycle. Whereas FOXO1 was shown to mediate insulin sensitivity and adipocyte differentiation, the role of the transcription factor FoxO4
Jun Zhu, Khalid Mounzih, Eric F. Chehab, Nico Mitro, Enrique Saez, Farid F. Chehab   +5 more
doaj   +1 more source

Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. [PDF]

PLoS ONE, 2014
The plant sterol pathway exhibits a major biosynthetic difference as compared with that of metazoans. The committed sterol precursor is the pentacyclic cycloartenol (9β,19-cyclolanost-24-en-3β-ol) and not lanosterol (lanosta-8,24-dien-3β-ol), as it was ...
Elisabet Gas-Pascual, Anne Berna, Thomas J Bach, Hubert Schaller   +3 more
doaj   +1 more source

Kajian in Silico Daun Sungkai (Peronema canescens) dalam Menghambat Enzim lanosterol 14-α demethylase Jamur Candida albicans

Indonesian Journal of Pharmaceutical Education, 2023
Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes,
Nurul Istiqomah, Safitri Fatikasari, Ariani H. Hutuba   +2 more
doaj   +1 more source

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S]

Journal of Lipid Research, 2019
Sterol-regulated HMG-CoA reductase (HMGCR) degradation and SREBP-2 cleavage are two major feedback regulatory mechanisms governing cholesterol biosynthesis.
Liang Chen, Mei-Yan Ma, Ming Sun, Lu-Yi Jiang, Xue-Tong Zhao, Xian-Xiu Fang, Sin Man Lam, Guang-Hou Shui, Jie Luo, Xiong-Jie Shi, Bao-Liang Song   +10 more
doaj   +1 more source

Efficient routes to epimerically-pure side-chain derivatives of lanosterol [PDF]

, 2004
A technically simple route is described to individual epimers of side-chain derivatives of lanosterol (3-hydroxy-5-lanosta-8,24-diene). Epimerically pure 24,25-epoxy-, 24,25-dihydroxy- and 24-bromo-25-hydroxy-lanosterol have been prepared in good yield ...
Nicholson, Brian K., Kavtaradze, Levan K., Manley-Harris, Merilyn   +2 more
core   +1 more source