Results 11 to 20 of about 11,121 (205)

Effect of lanosterol on human cataract nucleus

Indian Journal of Ophthalmology, 2015
Aim: To study the effect of lanosterol on age-related cataractous human lens nuclei. Materials and Methods: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol
P Mahesh Shanmugam, Aditya Barigali, Jayant Kadaskar, Sandip Borgohain, Divaynsh Kailash Chandra Mishra, Rajesh Ramanjulu, C K Minija   +6 more
doaj   +4 more sources

Biosynthesis of lanosterol in Escherichia coli

Synthetic and Systems Biotechnology
Lipid composition represents a significant differentiator across the three domains (eukaryotes, bacteria, and archaea) of cellular life. Eukaryotes possess distinct lipids, such as sterols and sphingolipids, generally, these are not commonly found in ...
Wenjie Sun, Yun Chen, Syed Bilal Shah, Yanfen Bai, Zaigao Tan   +4 more
doaj   +4 more sources

Using genetics to investigate the association between lanosterol and cataract [PDF]

Frontiers in Genetics
Background: Cataract is one of the most prevalent causes of blindness worldwide. Whilst surgery is the primary treatment for cataracts, it is not always an available option, particularly in developing countries.
Munisa Hashimi, Hasnat A. Amin, Loukas Zagkos, Alexander C. Day, Alexander C. Day, Fotios Drenos   +5 more
doaj   +4 more sources

Lanosterol Synthase Pathway Alleviates Lens Opacity in Age-Related Cortical Cataract

Journal of Ophthalmology, 2018
Purpose. Lanosterol synthase (LSS) abnormity contributes to lens opacity in rats, mice, dogs, and human congenital cataract development. This study examined whether LSS pathway has a role in different subtypes of age-related cataract (ARC). Methods.
Xinyue Shen, Manhui Zhu, Lihua Kang, Yuanyuan Tu, Lele Li, Rutan Zhang, Bai Qin, Mei Yang, Huaijin Guan   +8 more
doaj   +2 more sources

Lanosterol reverses protein aggregation in cataracts

Nature, 2015
The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparency and refractive index.
Ouyang, Hong, Chen, Xiang-Jun, Qiu, Austin, Zhao, Ling, Yang, Xu, Patel, Sherrina H., Jin, Xin, Wen, Cindy, Abagyan, Ruben, Wang, Yandong, Hou, Rui, Yeh, Emily, Lin, Ying, Hu, Xun, Cao, Guiqun, Hu, Li-Dan, Luo, Hongrong, Lin, Danni, Wu, Frances, Xi, Yi-Bo, Flagg, Ken, Wang, Wenqiu, Grob, Seanna, Su, Zhiguang, Tjondro, Harry Christianto, Cai, Huimin, Chen, Daniel, Zhao, Xi-Juan, Chung, Christopher, Li, Gen, Zhu, Jie   +30 more
core   +4 more sources

Lanosterol regulates abnormal amyloid accumulation in LECs through the mediation of cholesterol pathway metabolism

Biochemistry and Biophysics Reports
Age-related cataract (ARC) is the predominant cause of global blindness, linked to the progressive aging of the lens, oxidative stress, perturbed calcium homeostasis, hydration irregularities, and modifications in crystallin proteins. Currently, surgical
Yingxue Su, Danyuan Sun, Chen Cao, Yandong Wang   +3 more
doaj   +2 more sources

Phylogenetic and Structural Analysis of Miconazole Susceptibility in Malassezia pachydermatis Isolates From Dogs With Otitis Externa. [PDF]

Vet Dermatol
Background: An increased number of dogs with unresolved yeast otitis externa (OE) after miconazole treatment was observed at a tertiary practice. Hypothesis/Objectives: To evaluate miconazole susceptibility in Malassezia pachydermatis isolates from canine OE.
Belcher CM, Souza CP, McGuire E, Hung CC, Tyndall JDA, Hoyer LL.   +5 more
europepmc   +2 more sources

Design and Synthesis of Novel 1,2,3-Triazole Conjugates Featuring Hydroxamic Acid and Sulfonamide Moieties: Exploring Dual Pharmacophores for Enhanced Biological Activity. [PDF]

Chem Biol Drug Des
Design and synthesis of novel 1,2,3‐triazole conjugates featuring hydroxamic acid and sulfonamide moieties: exploring dual pharmacophores for enhanced biological activity. ABSTRACT A new series of N‐hydroxy‐1‐(4‐(aryl sulfonamido)phenyl)‐1H‐1,2,3‐triazole‐4‐carboxamide derivatives (8a‐j) were synthesized through a concise multistep route integrating ...
Pagar D, Shaw R, Suryavanshi H, Rajani D, Patil S.   +4 more
europepmc   +2 more sources

Sterol content of the Myxomycetes Physarum polycephalum and P. flavicomum

Journal of Lipid Research, 1976
The sterol content of two Myxomycetes, Physarum polycephalum and P. flavicomum has been examined. The sterols of the two species are apparently identical, the two major sterols in each being poriferasterol and 22-dihydroporiferasterol.
E Bullock, C J Dawson
doaj   +1 more source

Absolute structure of (3aS,5S,7aS,7bS,9aR,10R,12aR,12bS)-7b-hydroxy-4,4,7a,9a,12a-pentamethyl-10-[(2′R)-6-methylheptan-2-yl]-2,8,9-trioxooctadecahydrobenzo[d]indeno[4,5-b]azepin-5-yl acetate from 62-year-old crystals

Acta Crystallographica Section E: Crystallographic Communications, 2019
The structure of the title compound, C32H51NO6, was determined from 62-year-old crystals at room temperature and refined with 100 K data in a monoclinic (C2) space group. This compound with a triterpenoid structure, now confirmed by this study, played an
Leopoldo Suescun, Horacio Heinzen
doaj   +1 more source