Results 71 to 80 of about 191 (92)

The stereospecific synthesis of inotodiol 3β, 22R-dihydroxylanosta-8,24-diene

Tetrahedron, 1974
Abstract Inotodiol 1a has been stereospecifically synthesised from lanosterol in six steps and Horeau's method utilised to demonstrate the R-configuration at C-22.
J.P. Poyser, F. de Reinach Hirtzbach, G. Ourisson   +2 more
exaly   +2 more sources

Mechanism studies on α-glucosidase inhibition and glycemic regulation of inotodiol from Inonotus obliquus

Bioorganic Chemistry
Inonotus obliquus is a medicinal fungus that has been valued for its anti-diabetic properties in China for thousands of years. Inotodiol is a characteristic triterpenoid isolated from Inonotus obliquus. The inactivation effect and mechanism of α-glucosidase induced by inotodiol were investigated using fluorescence, FTIR, CD spectroscopy, and molecular ...
Haixia Chen
exaly   +3 more sources

The mast cell stabilizing activity of Chaga mushroom critical for its therapeutic effect on food allergy is derived from inotodiol

International Immunopharmacology, 2018
While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known. We examined the effect of 70% ethanol extract of Chaga mushroom (EE) and its dichloromethane (DF) and aqueous (AF) fractions ...
Jong-Seong Kang, Young Ho Kim, Inkyu Hwang   +2 more
exaly   +3 more sources

Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549

Chinese Journal of Integrative Medicine, 2011
To observe the proliferation inhibition, apoptosis, and cell proliferation cycle of human lung carcinoma cell line A549 treated with Inotodiol extracts from Inonotus obliquus and explore the possibility of Inotodiol extracts from Inonotus obliquus as a new tumor chemopreventive drug.Human lung cancer cell line A549 was treated with different ...
Xiu-Hong, Zhong, Li-Bo, Wang, Dong-Zhi, Sun   +2 more
exaly   +3 more sources

Glucose fed-batch integrated dissolved oxygen control strategy enhanced polysaccharide, total triterpenoids and inotodiol production in fermentation of a newly isolated Inonotus obliquus strain

Process Biochemistry, 2018
Abstract Submerged fermentation is promising for producing secondary metabolites of Inonotus obliquus, a folk medicine to treat cancer and other diseases. However, there limited progress work in strain selection or process optimization in order to enhance production of its bioactive metabolites.
Lianliang Liu
exaly   +2 more sources

Inotodiol ameliorates the progression of osteoarthritis: An in vitro and in vivo study

Drug Research, 2023
AbstractOsteoarthritis is a common chronic degenerative disease, of which the essence is the degenerative changes of bone and joint cartilage, involving damage in multiple structures such as bone, synovium and joints. In the mechanism of arthritis inflammation is closely related, and therefore
Wanfeng, Qian, Ruheng, Ji, Qiujie, Ye, Wenjun, Hu, Linying, Zhou, Hongwu, Pan, Xiaoming, Li   +6 more
openaire   +2 more sources

Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus

Bioorganic & Medicinal Chemistry, 2007
Two new lanostane-type triterpenoids, inonotsuoxides A (1) and B (2) along with three known lanostane-type triterpenoids, inotodiol (3), trametenolic acid (4), and lanosterol (5), were isolated from the sclerotia of Inonotus obliquus (Pers.: Fr.) (Japanese name: Kabanoanakake) (Russian name: Chaga).
Tomoko, Nakata, Takeshi, Yamada, Sayaka, Taji, Hirofumi, Ohishi, Shun-Ichi, Wada, Harukuni, Tokuda, Kazuo, Sakuma, Reiko, Tanaka   +7 more
openaire   +2 more sources

CE9A215 (inotodiol), a lanostane-type oxysterol, mitigates LPS-induced sepsis through multifaceted mechanisms

European Journal of Pharmacology
Dysregulated host response against infection triggers sepsis that leads to multiple organ dysfunction due to uncontrolled inflammatory responses. Despite marked progress in understanding of sepsis, numerous clinical trials for treatment of sepsis have proven daunting and a new therapeutic approach is highly needed.
Thi Minh Nguyet Nguyen, Hyunah Park, Thi Thuong Do, Ji-Yun Kwak, Chang-kyu Lee, Seung Hoon Lee, Jong-Il Park, Sun-Young Yoon, Hyunjung Kim, Jihyun Park, Jong-Tae Park   +10 more
openaire   +2 more sources

Structure Determination of Inonotsuoxides A (Ia) and B (Ib) and in vivo Antitumor Promoting Activity of Inotodiol (II) from the Sclerotia of Inonotus obliquus.

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Tomoko Nakata, Takeshi Yamada, Sayaka Taji, Hirofumi Ohishi, Shun‐ichi Wada, Harukuni Tokuka, Kazuo Sakuma, Reiko Tanaka   +7 more
openaire   +1 more source

Rapid Isolation and Purification of Inotodiol and Trametenolic Acid from Inonotus obliquus by High‐speed Counter‐current Chromatography with Evaporative Light Scatting Detection

Phytochemical Analysis, 2011
AbstractIntroductionIn Eastern Europe, especially Russia, the fruiting body of Inonotus obliquus has been used as a folk medicine for cancer since the sixteenth or seventeenth century. Inotodiol and trametenolic acid are considered to be the main bioactive compounds of the fruiting body of the mushroom.
Deyao, Du, Feng, Zhu, Xianhui, Chen, Xiuyun, Ju, Youjian, Feng, Lian-Wen, Qi, Jihong, Jiang   +6 more
openaire   +2 more sources